Varespladib attenuates Naja atra -induced acute liver injury via reversing Nrf2 signaling-mediated ferroptosis and mitochondrial dysfunction DOI Creative Commons
Jiahao Liu, Linfeng Wang,

Minqiang Xie

и другие.

Redox Report, Год журнала: 2025, Номер 30(1)

Опубликована: Май 21, 2025

Objective: To investigate the protective effects of varespladib against Naja atra-induced acute liver injury (ALI) and to elucidate toxic mechanism snake venom phospholipase A2 (SVPLA2)-induced hepatic oxidative stress, with a particular focus on role Nrf2 signaling its downstream pathways.Methods: A combination in vivo vitro models N. atra envenomation was employed assess injury, mitochondrial dysfunction. The interaction between SVPLA2 analyzed, treatment these processes were evaluated using histological analysis, biochemical assays, molecular techniques targeting ferroptosis, mitophagy, apoptosis.Results: Varespladib significantly alleviated ALI. found directly bind Nrf2, leading severe stress. This stress initiated cascade involving Nrf2-mediated dysfunction, excessive mitochondria-dependent apoptosis. Treatment effectively reversed pathological events by inhibiting activity.Conclusion: shows strong therapeutic potential for SVPLA2. identified as direct target SVPLA2, ferroptosis dysfunction key mechanisms underlying SVPLA2-induced injury.

Язык: Английский

Varespladib attenuates Naja atra -induced acute liver injury via reversing Nrf2 signaling-mediated ferroptosis and mitochondrial dysfunction DOI Creative Commons
Jiahao Liu, Linfeng Wang,

Minqiang Xie

и другие.

Redox Report, Год журнала: 2025, Номер 30(1)

Опубликована: Май 21, 2025

Objective: To investigate the protective effects of varespladib against Naja atra-induced acute liver injury (ALI) and to elucidate toxic mechanism snake venom phospholipase A2 (SVPLA2)-induced hepatic oxidative stress, with a particular focus on role Nrf2 signaling its downstream pathways.Methods: A combination in vivo vitro models N. atra envenomation was employed assess injury, mitochondrial dysfunction. The interaction between SVPLA2 analyzed, treatment these processes were evaluated using histological analysis, biochemical assays, molecular techniques targeting ferroptosis, mitophagy, apoptosis.Results: Varespladib significantly alleviated ALI. found directly bind Nrf2, leading severe stress. This stress initiated cascade involving Nrf2-mediated dysfunction, excessive mitochondria-dependent apoptosis. Treatment effectively reversed pathological events by inhibiting activity.Conclusion: shows strong therapeutic potential for SVPLA2. identified as direct target SVPLA2, ferroptosis dysfunction key mechanisms underlying SVPLA2-induced injury.

Язык: Английский

Процитировано

0