Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Март 22, 2023
Introduction:
The
microbiota–gut–brain
axis
plays
an
important
role
in
the
pathophysiology
of
autism
spectrum
disorder,
but
its
specific
mechanisms
remain
unclear.
This
study
aimed
to
explore
associations
changes
neurotransmitters
and
short-chain
fatty
acids
with
alterations
gut
microbiota
valproic
acid
model
rats.
Methods:
rats
were
established
by
prenatal
exposure
(VPA).
Morris
water
maze
test,
open
field
three-chamber
test
conducted
assess
behaviors
16S
rRNA
gene
sequences
extracted
from
fecal
samples
used
microbial
composition.
Gas
liquid
chromatography–mass
spectroscopy
was
identify
prefrontal
cortex
(PFC).
Results:
results
showed
that
28
bacterial
taxa
between
control
identified,
most
differential
belonged
metagenomic
species
Lactobacillus
intestinalis
.
Acetic
acid,
butyric
valeric
isobutyric
isovaleric
significantly
decreased
compared
those
Five
(threonine,
kynurenine,
tryptophan,
5-hydroxyindoleacetic
denoted
as
5-HIAA,
betaine
aldehyde
chloride,
BAC)
decreased,
whereas
increased
A
variety
(≥4)
correlated
Pseudomonas,
Collisella
,
Streptococcus
at
genus
level,
they
also
related
decrease
acids.
Discussion:
According
this
study,
we
can
preliminarily
infer
or
their
metabolic
productions
(such
SCFAs)
may
influence
central
neurotransmitter
metabolism
through
pathways
gut-brain
axis.
These
provide
(SCFA)
frameworks
for
understanding
disorder
shed
new
light
on
treatment.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Дек. 6, 2022
The
potential
of
edible
mushrooms
as
an
unexploited
treasure
trove,
although
rarely
included
in
known
food
guidelines,
is
highlighted.
Their
role
shielding
people
against
the
side
effects
unhealthy
stylish
diet
reviewed.
Mushrooms
complement
human
with
various
bioactive
molecules
not
identified
or
deficient
foodstuffs
plant
and
animal
sources,
being
considered
a
functional
for
prevention
several
diseases.
have
been
widely
used
medicinal
products
more
than
2,000
years,
but
globally
field
use
wild
has
untapped.
There
broad
range
which
remain
poorly
even
unreported
valuable
pool
sources
compounds
biopharma
utilization
new
dietary
supplements.
Some
unique
elements
their
preventative
healthcare
are
emphasized,
through
positive
impact
on
immune
system.
antiviral,
anti-inflammatory,
anti-neoplastic,
other
health
concerns
discussed.
incorporate
top
non-digestible
oligosaccharides,
ergothioneine,
humans
unable
to
synthesize,
later
antioxidant,
cytoprotective,
anti-inflammatory
element,
therapeutic
potential,
approved
by
world
agencies.
prebiotic
activity
beneficially
affects
gut
homeostasis
performance
balance
microbiota
enhanced.
Several
recent
studies
neurological
contribution
growth
nerve
brain
cells
mentioned.
Indeed,
foods'
nutraceuticals
presently
regarded
next-generation
foods,
supporting
wellness,
promising
prophylactic
agents.
Briefings in Bioinformatics,
Год журнала:
2022,
Номер
23(5)
Опубликована: Апрель 27, 2022
Abstract
Precision
medicine
uses
genetic,
environmental
and
lifestyle
factors
to
more
accurately
diagnose
treat
disease
in
specific
groups
of
patients,
it
is
considered
one
the
most
promising
medical
efforts
our
time.
The
use
genetics
arguably
data-rich
complex
components
precision
medicine.
grand
challenge
today
successful
assimilation
into
that
translates
across
different
ancestries,
diverse
diseases
other
distinct
populations,
which
will
require
clever
artificial
intelligence
(AI)
machine
learning
(ML)
methods.
Our
goal
here
was
review
compare
scientific
objectives,
methodologies,
datasets,
data
sources,
ethics
gaps
AI/ML
approaches
used
genomics
We
selected
high-quality
literature
published
within
last
5
years
were
indexed
available
through
PubMed
Central.
scope
narrowed
articles
reported
application
algorithms
for
statistical
predictive
analyses
using
whole
genome
and/or
exome
sequencing
gene
variants,
RNA-seq
microarrays
expression.
did
not
limit
search
or
sources.
Based
on
comparative
analysis
criteria,
we
identified
32
applied
variable
studies
report
widely
adapted
diagnostics
several
diseases.
Clinical Microbiology Reviews,
Год журнала:
2024,
Номер
37(2)
Опубликована: Май 8, 2024
SUMMARYGiven
the
importance
of
gut
microbial
homeostasis
in
maintaining
health,
there
has
been
considerable
interest
developing
innovative
therapeutic
strategies
for
restoring
microbiota.
One
such
approach,
fecal
microbiota
transplantation
(FMT),
is
main
"whole
microbiome
replacement"
strategy
and
integrated
into
clinical
practice
guidelines
treating
recurrent
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(4), С. 1332 - 1355
Опубликована: Янв. 1, 2024
Polyphenolic
compounds
have
shown
promising
neuroprotective
properties,
making
them
a
valuable
resource
for
identifying
prospective
drug
candidates
to
treat
several
neurological
disorders
(NDs).Numerous
studies
reported
that
polyphenols
can
disrupt
the
nuclear
factor
kappa
B(NF-κB)
pathway
by
inhibiting
phosphorylation
or
ubiquitination
of
signaling
molecules,
which
further
prevents
degradation
IκB.Additionally,
they
prevent
NF-κB
translocation
nucleus
and
pro-inflammatory
cytokine
production.Polyphenols
such
as
curcumin,
resveratrol,
pterostilbene
had
significant
inhibitory
effects
on
NF-κB,
treating
NDs.Recent
experimental
findings
suggest
possess
wide
range
pharmacological
properties.Notably,
much
attention
has
been
directed
towards
their
potential
therapeutic
in
NDs
Alzheimer's
disease
(AD),
Parkinson's
(PD),
cerebral
ischemia,
anxiety,
depression,
autism,
spinal
cord
injury
(SCI).Much
preclinical
data
supporting
neurotherapeutic
benefits
developed.Nevertheless,
this
study
described
significance
agents,
specifically
emphasizing
impact
pathway.This
article
offers
comprehensive
analysis
involvement
NDs,
including
both
clinical
perspectives.
Medicinal Research Reviews,
Год журнала:
2024,
Номер
44(3), С. 1267 - 1325
Опубликована: Янв. 16, 2024
Neuropsychiatric
disorders
denote
a
broad
range
of
illnesses
involving
neurology
and
psychiatry.
These
include
depressive
disorders,
anxiety,
schizophrenia,
bipolar
disorder,
attention
deficit
hyperactivity
autism
spectrum
headaches,
epilepsy.
In
addition
to
their
main
neuropathology
that
lies
in
the
central
nervous
system
(CNS),
lately,
studies
have
highlighted
role
immunity
neuroinflammation
neuropsychiatric
disorders.
Toll-like
receptors
(TLRs)
are
innate
act
as
bridge
between
adaptive
immune
systems
via
adaptor
proteins
(e.g.,
MYD88)
downstream
elements;
TLRs
classified
into
13
families
involved
normal
function
CNS.
expression
affects
course
is
influenced
during
pharmacotherapy;
For
example,
multiple
normalized
major
disorder
pharmacotherapy.
Here,
neuroimmunology,
treatment,
management
discussed.
We
recommend
longitudinal
comparatively
assess
cell-type-specific
illness
progression,
remission.
Also,
further
research
should
explore
molecular
insights
regulation
related
pathways.
Neuropsychiatric Disease and Treatment,
Год журнала:
2021,
Номер
Volume 17, С. 3509 - 3529
Опубликована: Дек. 1, 2021
Abstract:
This
comprehensive
thematic
review
aims
to
highlight
and
familiarize
readers
with
the
challenges
pitfalls
encountered
in
differential
diagnosis
of
autism
spectrum
disorders
(ASD)
children
facilitate
process
accurate
identification
by
stakeholders.
Accordingly,
articles
that
best
answer
our
questions
concerns
were
chosen
from
well-established
publishers
prime
peer
reviewed
journals.
Included
are
studies
showing
alternate
views
issues
so
as
point
other
possibilities.
ASD,
a
complex
dynamic
biological-neurodevelopmental
disorder,
is
underscored
its
heterogeneous
symptomology,
severity,
phenotypes
–
all
characterized
social
communication
deficits
presence
restricted
interests
repetitive
behaviours
(RRBs),
core
symptoms
ASD.
Language
intellectual
capacities
do
not
form
ASD
although
vary
considerably.
Accurate
challenging
often
enmeshed
neurodevelopmental
disorders,
medical
comorbidities,
situation
now
recognized
rule
rather
than
exception
child
psychiatry
developmental
medicine.
disorder
varying
performance
severity
over
time,
including
unexpected
loss
early
skills,
lost
some
following
treatment.
The
reiterates
urgency
face
rapid
rise
prevalence
globally,
risk-increase
delayed
or
denied
treatment
undesirable
life-long
consequences
for
most
affected
children.
In
addition,
call
change
advised
circumvent
ethical
dilemma
posed
present
“deficit
model”
diagnosis.
Here,
presented
first,
followed
emphasis
on
importance
diagnosis,
accomplishment
due
flaws
diagnostic
instruments
contributing
factors.
Next
follow
required
criteria
identification,
difficulties
attributed
comorbid
conditions,
gender
differences,
socio-economic
cultural
influences.
conclusion
includes
future
directions
take
away
message.
Keywords:
autism,
missed
misdiagnosis,
Applied Sciences,
Год журнала:
2020,
Номер
10(8), С. 2924 - 2924
Опубликована: Апрель 23, 2020
Over
recent
years,
robots
are
increasingly
being
employed
in
several
aspects
of
modern
society.
Among
others,
social
have
the
potential
to
benefit
education,
healthcare,
and
tourism.
To
achieve
this
purpose,
should
be
able
engage
humans,
recognize
users’
emotions,
some
extent
properly
react
"behave"
a
natural
interaction.
Most
robotics
applications
primarily
use
visual
information
for
emotion
recognition,
which
is
often
based
on
facial
expressions.
However,
display
emotional
states
through
expression
inherently
voluntary
controlled
process
that
typical
human–human
In
fact,
humans
not
yet
learned
channel
when
communicating
with
robotic
technology.
Hence,
there
an
urgent
need
exploit
channels
directly
by
such
as
those
can
ascribed
physiological
modulations.
Thermal
infrared
imaging-based
affective
computing
has
solution
issue.
It
validated
technology
allows
non-obtrusive
monitoring
parameters
from
it
might
possible
infer
states.
This
review
aimed
outline
advantages
current
research
challenges
thermal
human–robot
JAMA Pediatrics,
Год журнала:
2021,
Номер
175(2), С. e205371 - e205371
Опубликована: Янв. 4, 2021
The
risk
of
substance
use
disorder
(SUD)
in
patients
with
autism
spectrum
(ASD)
remains
unclear.To
investigate
the
SUD
ASD
and
its
associations
comorbidities,
psychotropic
agents
(PAs),
mortality.This
retrospective,
population-based,
cohort
study
1
936
512
participants
used
data
from
Taiwan
National
Health
Insurance
Research
Database
was
conducted
January
1,
2000,
to
December
31,
2015.
Included
attended
at
least
3
outpatient
visits
within
1-year
period
for
symptomatic
as
determined
by
International
Classification
Diseases,
Ninth
Revision,
Clinical
Modification
(ICD-9-CM)
diagnostic
codes.
Individuals
diagnosed
before
those
first
visit
ASD,
missing
were
excluded
analysis.
Patients
non-ASD
controls
matched
1:4
age,
sex,
index
date.Symptomatic
evaluated
period.Adjusted
hazard
ratios
(aHRs)
95%
CIs
SUD,
including
alcohol
(AUD)
drug
(DUD),
mortality
calculated.
Data
analyzed
March
July
13,
2020.A
total
6599
individuals
(mean
[SD]
11.9
[5.1]
years;
5094
boys
[77.2%];
mean
follow-up
period,
8.1
[8.3]
median
4.3
[interquartile
range
[IQR],
2.3-5.3]
years)
26
396
12.1
[5.8]
20
376
8.6
[8.9]
4.4
[IQR,
2.4-5.4]
enrolled
study.
According
multivariable-adjusted
analysis,
aHRs
(2.33;
CI,
1.89-2.87),
AUD
(2.07;
1.60-2.63),
DUD
(3.00;
2.15-4.58)
significantly
higher
group
than
controls.
subgroups
PA
(0.60;
0.43-0.66)
multiple
PAs
(0.37;
0.28-0.49)
lower
subgroup
no
PAs.
Comparisons
between
same
comorbidities
showed
among
(range,
1.17-2.55);
moreover,
not
receiving
any
had
an
aHR
6.39
(95%
5.11-7.87)
when
they
comorbid
tic
5.48
5.12-5.70)
5.42
5.12-5.80)
impulse
control
disorder.
concomitant
without
(aHR,
3.17;
2.69-3.89).These
findings
suggest
that
are
vulnerable
development
SUD.
Comorbid
associated
increase
risk.
Journal of Traditional and Complementary Medicine,
Год журнала:
2022,
Номер
13(2), С. 135 - 149
Опубликована: Март 8, 2022
Autism
is
a
complex
neurodevelopmental
disorder
which
disrupts
communication,
social
and
interactive
skills
followed
by
appearance
of
repetitive
behavior.
The
underlying
etiology
remains
incomprehensible
but
genetic
environmental
factors
play
key
role.
Accumulated
evidence
shows
that
alteration
in
level
gut
microbes
their
metabolites
are
not
only
linked
to
gastrointestinal
problems
also
autism.
So
far
the
mix
present
affects
human
health
numerous
ways
through
extensive
bacterial-mammalian
cometabolism
has
marked
influence
over
via
gut-brain-microbial
interactions.
Healthy
microbiota
may
even
ease
symptoms
autism,
as
microbial
balance
influences
brain
development
neuroendocrine,
neuroimmune,
autonomic
nervous
systems.
In
this
article,
we
focused
on
reviewing
correlation
between
autism
utilizing
prebiotics,
probiotics
herbal
remedies
target
microflora
hence