Mushrooms as future generation healthy foods

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Дек. 6, 2022

The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role shielding people against the side effects unhealthy stylish diet reviewed. Mushrooms complement human with various bioactive molecules not identified or deficient foodstuffs plant and animal sources, being considered a functional for prevention several diseases. have been widely used medicinal products more than 2,000 years, but globally field use wild has untapped. There broad range which remain poorly even unreported valuable pool sources compounds biopharma utilization new dietary supplements. Some unique elements their preventative healthcare are emphasized, through positive impact on immune system. antiviral, anti-inflammatory, anti-neoplastic, other health concerns discussed. incorporate top non-digestible oligosaccharides, ergothioneine, humans unable to synthesize, later antioxidant, cytoprotective, anti-inflammatory element, therapeutic potential, approved by world agencies. prebiotic activity beneficially affects gut homeostasis performance balance microbiota enhanced. Several recent studies neurological contribution growth nerve brain cells mentioned. Indeed, foods' nutraceuticals presently regarded next-generation foods, supporting wellness, promising prophylactic agents.

Язык: Английский

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Artificial intelligence and machine learning approaches using gene expression and variant data for personalized medicine

Briefings in Bioinformatics, Год журнала: 2022, Номер 23(5)

Опубликована: Апрель 27, 2022

Abstract Precision medicine uses genetic, environmental and lifestyle factors to more accurately diagnose treat disease in specific groups of patients, it is considered one the most promising medical efforts our time. The use genetics arguably data-rich complex components precision medicine. grand challenge today successful assimilation into that translates across different ancestries, diverse diseases other distinct populations, which will require clever artificial intelligence (AI) machine learning (ML) methods. Our goal here was review compare scientific objectives, methodologies, datasets, data sources, ethics gaps AI/ML approaches used genomics We selected high-quality literature published within last 5 years were indexed available through PubMed Central. scope narrowed articles reported application algorithms for statistical predictive analyses using whole genome and/or exome sequencing gene variants, RNA-seq microarrays expression. did not limit search or sources. Based on comparative analysis criteria, we identified 32 applied variable studies report widely adapted diagnostics several diseases.

Язык: Английский

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Fecal microbiota transplantation: current challenges and future landscapes

Clinical Microbiology Reviews, Год журнала: 2024, Номер 37(2)

Опубликована: Май 8, 2024

SUMMARYGiven the importance of gut microbial homeostasis in maintaining health, there has been considerable interest developing innovative therapeutic strategies for restoring microbiota. One such approach, fecal microbiota transplantation (FMT), is main "whole microbiome replacement" strategy and integrated into clinical practice guidelines treating recurrent

Язык: Английский

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Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(4), С. 1332 - 1355

Опубликована: Янв. 1, 2024

Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs).Numerous studies reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting phosphorylation or ubiquitination of signaling molecules, which further prevents degradation IκB.Additionally, they prevent NF-κB translocation nucleus and pro-inflammatory cytokine production.Polyphenols such as curcumin, resveratrol, pterostilbene had significant inhibitory effects on NF-κB, treating NDs.Recent experimental findings suggest possess wide range pharmacological properties.Notably, much attention has been directed towards their potential therapeutic in NDs Alzheimer's disease (AD), Parkinson's (PD), cerebral ischemia, anxiety, depression, autism, spinal cord injury (SCI).Much preclinical data supporting neurotherapeutic benefits developed.Nevertheless, this study described significance agents, specifically emphasizing impact pathway.This article offers comprehensive analysis involvement NDs, including both clinical perspectives.

Язык: Английский

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The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management

Medicinal Research Reviews, Год журнала: 2024, Номер 44(3), С. 1267 - 1325

Опубликована: Янв. 16, 2024

Neuropsychiatric disorders denote a broad range of illnesses involving neurology and psychiatry. These include depressive disorders, anxiety, schizophrenia, bipolar disorder, attention deficit hyperactivity autism spectrum headaches, epilepsy. In addition to their main neuropathology that lies in the central nervous system (CNS), lately, studies have highlighted role immunity neuroinflammation neuropsychiatric disorders. Toll-like receptors (TLRs) are innate act as bridge between adaptive immune systems via adaptor proteins (e.g., MYD88) downstream elements; TLRs classified into 13 families involved normal function CNS. expression affects course is influenced during pharmacotherapy; For example, multiple normalized major disorder pharmacotherapy. Here, neuroimmunology, treatment, management discussed. We recommend longitudinal comparatively assess cell-type-specific illness progression, remission. Also, further research should explore molecular insights regulation related pathways.

Язык: Английский

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Sleep Problems in 2- to 5-Year-Olds With Autism Spectrum Disorder and Other Developmental Delays

PEDIATRICS, Год журнала: 2019, Номер 143(3)

Опубликована: Фев. 11, 2019

: media-1vid110.1542/5984243260001PEDS-VA_2018-0492

Язык: Английский

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Challenges Surrounding the Diagnosis of Autism in Children

Neuropsychiatric Disease and Treatment, Год журнала: 2021, Номер Volume 17, С. 3509 - 3529

Опубликована: Дек. 1, 2021

Abstract: This comprehensive thematic review aims to highlight and familiarize readers with the challenges pitfalls encountered in differential diagnosis of autism spectrum disorders (ASD) children facilitate process accurate identification by stakeholders. Accordingly, articles that best answer our questions concerns were chosen from well-established publishers prime peer reviewed journals. Included are studies showing alternate views issues so as point other possibilities. ASD, a complex dynamic biological-neurodevelopmental disorder, is underscored its heterogeneous symptomology, severity, phenotypes – all characterized social communication deficits presence restricted interests repetitive behaviours (RRBs), core symptoms ASD. Language intellectual capacities do not form ASD although vary considerably. Accurate challenging often enmeshed neurodevelopmental disorders, medical comorbidities, situation now recognized rule rather than exception child psychiatry developmental medicine. disorder varying performance severity over time, including unexpected loss early skills, lost some following treatment. The reiterates urgency face rapid rise prevalence globally, risk-increase delayed or denied treatment undesirable life-long consequences for most affected children. In addition, call change advised circumvent ethical dilemma posed present “deficit model” diagnosis. Here, presented first, followed emphasis on importance diagnosis, accomplishment due flaws diagnostic instruments contributing factors. Next follow required criteria identification, difficulties attributed comorbid conditions, gender differences, socio-economic cultural influences. conclusion includes future directions take away message. Keywords: autism, missed misdiagnosis,

Язык: Английский

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Thermal Infrared Imaging-Based Affective Computing and Its Application to Facilitate Human Robot Interaction: A Review

Applied Sciences, Год журнала: 2020, Номер 10(8), С. 2924 - 2924

Опубликована: Апрель 23, 2020

Over recent years, robots are increasingly being employed in several aspects of modern society. Among others, social have the potential to benefit education, healthcare, and tourism. To achieve this purpose, should be able engage humans, recognize users’ emotions, some extent properly react "behave" a natural interaction. Most robotics applications primarily use visual information for emotion recognition, which is often based on facial expressions. However, display emotional states through expression inherently voluntary controlled process that typical human–human In fact, humans not yet learned channel when communicating with robotic technology. Hence, there an urgent need exploit channels directly by such as those can ascribed physiological modulations. Thermal infrared imaging-based affective computing has solution issue. It validated technology allows non-obtrusive monitoring parameters from it might possible infer states. This review aimed outline advantages current research challenges thermal human–robot

Язык: Английский

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Risk of Substance Use Disorder and Its Associations With Comorbidities and Psychotropic Agents in Patients With Autism

JAMA Pediatrics, Год журнала: 2021, Номер 175(2), С. e205371 - e205371

Опубликована: Янв. 4, 2021

The risk of substance use disorder (SUD) in patients with autism spectrum (ASD) remains unclear.To investigate the SUD ASD and its associations comorbidities, psychotropic agents (PAs), mortality.This retrospective, population-based, cohort study 1 936 512 participants used data from Taiwan National Health Insurance Research Database was conducted January 1, 2000, to December 31, 2015. Included attended at least 3 outpatient visits within 1-year period for symptomatic as determined by International Classification Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnostic codes. Individuals diagnosed before those first visit ASD, missing were excluded analysis. Patients non-ASD controls matched 1:4 age, sex, index date.Symptomatic evaluated period.Adjusted hazard ratios (aHRs) 95% CIs SUD, including alcohol (AUD) drug (DUD), mortality calculated. Data analyzed March July 13, 2020.A total 6599 individuals (mean [SD] 11.9 [5.1] years; 5094 boys [77.2%]; mean follow-up period, 8.1 [8.3] median 4.3 [interquartile range [IQR], 2.3-5.3] years) 26 396 12.1 [5.8] 20 376 8.6 [8.9] 4.4 [IQR, 2.4-5.4] enrolled study. According multivariable-adjusted analysis, aHRs (2.33; CI, 1.89-2.87), AUD (2.07; 1.60-2.63), DUD (3.00; 2.15-4.58) significantly higher group than controls. subgroups PA (0.60; 0.43-0.66) multiple PAs (0.37; 0.28-0.49) lower subgroup no PAs. Comparisons between same comorbidities showed among (range, 1.17-2.55); moreover, not receiving any had an aHR 6.39 (95% 5.11-7.87) when they comorbid tic 5.48 5.12-5.70) 5.42 5.12-5.80) impulse control disorder. concomitant without (aHR, 3.17; 2.69-3.89).These findings suggest that are vulnerable development SUD. Comorbid associated increase risk.

Язык: Английский

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Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives

Journal of Traditional and Complementary Medicine, Год журнала: 2022, Номер 13(2), С. 135 - 149

Опубликована: Март 8, 2022

Autism is a complex neurodevelopmental disorder which disrupts communication, social and interactive skills followed by appearance of repetitive behavior. The underlying etiology remains incomprehensible but genetic environmental factors play key role. Accumulated evidence shows that alteration in level gut microbes their metabolites are not only linked to gastrointestinal problems also autism. So far the mix present affects human health numerous ways through extensive bacterial-mammalian cometabolism has marked influence over via gut-brain-microbial interactions. Healthy microbiota may even ease symptoms autism, as microbial balance influences brain development neuroendocrine, neuroimmune, autonomic nervous systems. In this article, we focused on reviewing correlation between autism utilizing prebiotics, probiotics herbal remedies target microflora hence

Язык: Английский

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