Food Selectivity and Its Implications Associated with Gastrointestinal Disorders in Children with Autism Spectrum Disorders

Nutrients, Год журнала: 2022, Номер 14(13), С. 2660 - 2660

Опубликована: Июнь 27, 2022

Food selectivity (FS) in children with autism spectrum disorders (ASD) is common, and its impact on a nutritional level known. However, the etiology of gastrointestinal (GID) related to alterations intestinal microbiota ASD remains unclear. This article provides narrative review literature FS from last 15 years, relationship GID ASD. Sensory aversion leads food elimination, based consistencies, preferences, other sensory issues. The restriction groups that modulate gut microbiota, such as fruits vegetables, well fibers some cereals, triggers an dysbiosis increased abundance Enterobacteriaceae, Salmonella Escherichia/Shigella, Clostridium XIVa, which, together aberrant immune response leaky gut, may trigger GID. It observed can be product previous could provide information generate hypothesis bidirectional between Emphasis placed need for more studies methodological rigor selecting ASD, homogeneous criteria evaluation GID, adequate classification

Язык: Английский

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An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2023, Номер 128, С. 110861 - 110861

Опубликована: Сен. 9, 2023

There is a lot of evidence establishing that nervous system development related to the composition and functions gut microbiome. In addition, central (CNS) controls imbalance intestinal microbiota, constituting bidirectional communication system. At present, various gut-brain crosstalk routes have been described, including immune, endocrine neural circuits via vagal pathway. Several empirical data associated microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism Parkinson's other psychological disorders, like anxiety depression. Fecal transplantation (FMT) therapy has shown can transfer behavioral features recipient animals, which provides strong establish causal-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, demonstrated an important influence neurological disorders by synthesis neuroactive compounds interact regulation inflammatory processes. Further research needed demonstrate dysbiosis psychiatric how microbiota-based interventions may be used potential therapeutic tools.

Язык: Английский

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Classifying Autism From Crowdsourced Semistructured Speech Recordings: Machine Learning Model Comparison Study

JMIR Pediatrics and Parenting, Год журнала: 2022, Номер 5(2), С. e35406 - e35406

Опубликована: Янв. 25, 2022

Autism spectrum disorder (ASD) is a neurodevelopmental that results in altered behavior, social development, and communication patterns. In recent years, autism prevalence has tripled, with 1 44 children now affected. Given traditional diagnosis lengthy, labor-intensive process requires the work of trained physicians, significant attention been given to developing systems automatically detect autism. We toward this goal by analyzing audio data, as prosody abnormalities are signal autism, affected displaying speech idiosyncrasies such echolalia, monotonous intonation, atypical pitch, irregular linguistic stress

Язык: Английский

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Roles of the Oxytocin Receptor (OXTR) in Human Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3887 - 3887

Опубликована: Фев. 15, 2023

The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for signal transduction after binding its ligand, oxytocin. Although this signaling primarily involved in controlling maternal behavior, it was demonstrated that also plays a role development of nervous system. Therefore, not surprise both ligand and are modulation behaviors, especially those related to sexual, social, stress-induced activities. As case every regulatory system, any disturbances structures or functions may lead various diseases regulated functions, which include either mental problems (autism, depression, schizophrenia, obsessive-compulsive disorders) functioning reproductive organs (endometriosis, uterine adenomyosis, premature birth). Nevertheless, abnormalities connected other diseases, including cancer, cardiac disorders, osteoporosis, obesity. Recent reports indicated changes levels formation aggregates influence course some inherited metabolic such as mucopolysaccharidoses. In review, involvement dysfunctions polymorphisms different summarized discussed. analysis published results led us suggest expression abundance activity specific individual but rather they processes (mostly behavioral changes) might modulate disorders. Moreover, possible explanation discrepancies effects gene methylation on proposed.

Язык: Английский

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Caseins: Versatility of Their Micellar Organization in Relation to the Functional and Nutritional Properties of Milk

Molecules, Год журнала: 2023, Номер 28(5), С. 2023 - 2023

Опубликована: Фев. 21, 2023

The milk of mammals is a complex fluid mixture various proteins, minerals, lipids, and other micronutrients that play critical role in providing nutrition immunity to newborns. Casein proteins together with calcium phosphate form large colloidal particles, called casein micelles. Caseins their micelles have received great scientific interest, but versatility the functional nutritional properties from different animal species are not fully understood. belong class exhibit open flexible conformations. Here, we discuss key features maintain structures protein sequences four selected species: cow, camel, human, African elephant. primary these posttranslational modifications (phosphorylation glycosylation) determine secondary distinctively evolved species, leading differences structural, functional, properties. variability caseins influence dairy products, such as cheese yogurt, well digestibility allergic Such beneficial development functionally improved molecules variable biological industrial utilities.

Язык: Английский

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Role of gastrointestinal health in managing children with autism spectrum disorder

World Journal of Clinical Pediatrics, Год журнала: 2023, Номер 12(4), С. 171 - 196

Опубликована: Сен. 5, 2023

Children with autism spectrum disorders (ASD) or are more prone to gastrointestinal (GI) than the general population. These can significantly affect their health, learning, and development due various factors such as genetics, environment, behavior. The causes of GI in children ASD include gut dysbiosis, immune dysfunction, food sensitivities, digestive enzyme deficiencies, sensory processing differences. Many studies suggest that numerous experience problems, effective management is crucial. Diagnosing typically done through genetic, neurological, functional, behavioral assessments observations, while tests not consistently reliable. Some may increase risk developing exacerbating symptoms. Addressing issues individuals improve overall well-being, leading better behavior, cognitive function, educational abilities. Proper digestion, nutrient absorption, appetite by relieving physical discomfort pain. Alleviating symptoms sleep patterns, energy levels, contribute a sense ultimately quality life for individual improved family dynamics. primary goal interventions nutritional status, reduce symptom severity, promote balanced mood, patient independence.

Язык: Английский

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Disentangling the role of gray matter volume and concentration in autism spectrum disorder: A meta-analytic investigation of 25 years of voxel-based morphometry research

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 164, С. 105791 - 105791

Опубликована: Июль 2, 2024

Despite over two decades of neuroimaging research, a unanimous definition the pattern structural variation associated with autism spectrum disorder (ASD) has yet to be found. One potential impeding issue could sometimes ambiguous use measurements variations in gray matter volume (GMV) or concentration (GMC). In fact, while both can calculated using voxel-based morphometry analysis, these may reflect different underlying pathological mechanisms. We conducted coordinate-based meta-analysis, keeping apart GMV and GMC studies subjects ASD. Results showed distinct non-overlapping patterns for measures. decreases were evident cerebellum, mainly found temporal frontal regions. increases parietal, temporal, brain regions, observed anterior cingulate cortex middle gyrus. Age-stratified analyses suggested that such are dynamic across ASD lifespan. The present findings emphasize importance considering as synergistic indices research.

Язык: Английский

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Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Phytotherapy Research, Год журнала: 2024, Номер 38(3), С. 1400 - 1461

Опубликована: Янв. 17, 2024

Abstract Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for development of new effective therapeutics treat them. Stilbenes, with resveratrol attracting most attention, example multi‐target compounds promising therapeutic potential broad array neuropsychiatric and neurological conditions. This review is comprehensive summary current state research on stilbenes several such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, neurodegenerative disorders. We describe discuss results both vitro vivo studies. The majority studies concentrate resveratrol, limited findings exploring other pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic derivatives. Overall, although extensive preclinical show benefits various central nervous system clinical evidence their efficacy largely missing.

Язык: Английский

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Associations between brake and tire wear-related PM2.5 metal components, particulate oxidative stress potential, and autism spectrum disorder in Southern California

Environment International, Год журнала: 2024, Номер 185, С. 108573 - 108573

Опубликована: Март 1, 2024

Air pollution is a global health concern, with fine particulate matter (PM2.5) constituents posing potential risks to human health, including children's neurodevelopment. Here we investigated associations between exposure during pregnancy and infancy specific traffic-related PM2.5 components Autism Spectrum Disorder (ASD) diagnosis. For assessment, estimated related traffic (Barium [Ba] as marker of brake dust Zinc [Zn] tire wear marker, Black Carbon [BC]) oxidative stress (OSP) markers (Hydroxyl Radical [OPOH] formation, Dithiothreitol activity [OPDTT], reactive oxygen species [ROS]) modeled land use regression co-kriging based on an intensive air monitoring campaign. We assigned exposures cohort 444,651 children born in Southern California 2016 2019, among whom 11,466 ASD cases were diagnosed 2018 2022, Odds ratios (ORs) 95% confidence intervals (CIs) obtained logistic for single pollutant mass co-adjusted models, also adjusting sociodemographic characteristics. Among components, found the strongest positive association our Ba (ORper IQR = 1.29, 95 % CI: 1.24, 1.34). This was followed by increased risk all markers; ROS formation 1.22, 1.18, 1.25). linked Hispanic children, but not White while OSP across groups. In neighborhoods lowest socioeconomic status (SES), stronger examined pollutants compared higher SES areas. Our findings suggest that wear-related are associated diagnosis California. These results strategies aimed at reducing public impacts need consider sources.

Язык: Английский

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Diagnosis of autism spectrum disorder: a systematic review of clinical and artificial intelligence methods

Network Modeling Analysis in Health Informatics and Bioinformatics, Год журнала: 2025, Номер 14(1)

Опубликована: Янв. 10, 2025

Язык: Английский

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