3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration DOI Creative Commons

Rosa Sparaco,

Pierfrancesco Cinque,

Antonia Scognamiglio

и другие.

Molecules, Год журнала: 2024, Номер 29(7), С. 1598 - 1598

Опубликована: Апрель 3, 2024

4-Nitro and 7-nitro propranolol have been recently synthesized characterized by us. (±)-4-NO2-propranolol has shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium rats. As part our follow-up this study, herein, we describe first synthesis (±)-3-nitroatenolol probe evaluate potential nitration atenolol endothelium. Chiral chromatography was used produce pure enantiomers. By using Riguera’s method, which is based on sign distribution ΔδH, absolute configuration secondary alcohol determined.

Язык: Английский

3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration DOI Creative Commons

Rosa Sparaco,

Pierfrancesco Cinque,

Antonia Scognamiglio

и другие.

Molecules, Год журнала: 2024, Номер 29(7), С. 1598 - 1598

Опубликована: Апрель 3, 2024

4-Nitro and 7-nitro propranolol have been recently synthesized characterized by us. (±)-4-NO2-propranolol has shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium rats. As part our follow-up this study, herein, we describe first synthesis (±)-3-nitroatenolol probe evaluate potential nitration atenolol endothelium. Chiral chromatography was used produce pure enantiomers. By using Riguera’s method, which is based on sign distribution ΔδH, absolute configuration secondary alcohol determined.

Язык: Английский

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