System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice
Animal Models and Experimental Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
It
is
increasingly
recognized
that
young,
chow-fed
inbred
mice
poorly
model
the
complexity
of
human
carcinogenesis.
In
humans,
age
and
adiposity
are
major
risk
factors
for
malignancies,
but
most
genetically
engineered
mouse
models
(GEMM)
induce
carcinogenesis
too
rapidly
to
study
these
influences.
Standard
strains,
such
as
C57BL/6,
commonly
used
in
GEMMs,
further
limit
exploration
aging
metabolic
health
effects.
A
similar
challenge
arises
modeling
periodontitis,
a
disease
influenced
by
aging,
diabesity,
genetic
architecture.
We
propose
using
diverse
populations
with
hybrid
vigor,
Collaborative
Cross
(CC)
×
ApcMin
hybrid,
slow
progression
better
colorectal
cancer
(CRC)
comorbidities.
This
perspective
highlights
advantages
this
model,
where
delayed
reveals
interactions
adiposity.
Unlike
mice,
which
develop
rapidly,
CC
hybrids
recapitulate
human-like
progression.
facilitates
identification
modifier
loci
affecting
inflammation,
diet
susceptibility,
organ
size,
polyposis
distribution.
The
offers
transformative
platform
studying
CRC
adulthood,
reflecting
its
complex
interplay
insights
gained
from
approach
will
enhance
early
detection,
management,
treatment
strategies
related
conditions.
Язык: Английский
The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes
Animal Models and Experimental Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Abstract
Background
Over
the
past
few
decades,
a
threefold
increase
in
obesity
and
type
2
diabetes
(T2D)
has
placed
heavy
burden
on
health‐care
system
society.
Previous
studies
have
shown
correlations
between
obesity,
T2D,
neurodegenerative
diseases,
including
dementia.
It
is
imperative
to
further
understand
relationship
cognitive
deficits.
Methods
This
investigation
tested
evaluated
impact
of
T2D
induced
by
high‐fat
diet
(HFD)
effect
host
genetic
background
severity
decline
caused
collaborative
cross
(CC)
mice.
The
CC
mice
are
genetically
diverse
panel
derived
from
eight
inbred
strains.
Results
Our
findings
demonstrated
significant
variations
recorded
phenotypes
across
different
lines
compared
reference
mouse
line,
C57BL/6J.
CC037
line
exhibited
substantial
body
weight
HFD,
whereas
CC005
differing
responses
based
sex.
Glucose
tolerance
tests
revealed
variations,
with
some
like
showing
marked
area
under
curve
(AUC)
values
HFD.
Organ
weights,
brain,
spleen,
liver,
kidney,
varied
significantly
among
sexes
response
Behavioral
using
Morris
water
maze
indicated
that
performance
was
differentially
affected
background.
Conclusions
study
establishes
foundation
for
future
quantitative
trait
loci
mapping
identifying
genes
underlying
comorbidity
Alzheimer's
disease
(AD),
T2D.
components
may
offer
new
tools
early
prediction
prevention.
Язык: Английский