Epidemiological and clinical characteristics of COVID-19 mortality: a retrospective study DOI Creative Commons
Yaohua Hu, You Lü, Jianzeng Dong

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 10, 2025

Background The global impact of SARS-CoV-2 and its associated coronavirus disease (COVID-19) has necessitated urgent characterization prognostic biomarkers. This study aimed to delineate the epidemiological clinical predictors mortality among hospitalized COVID-19 patients. Methods A retrospective cohort was conducted on 123 patients with laboratory-confirmed admitted Huoshenshan Hospital (Wuhan, China) from 1 February 2020 30 April 2020. Kaplan–Meier curve multivariate Cox regression were used assess independent factors survival time. Statistical significance set at a p -value <0.05. Results exhibited rate 49.6% (61/123), critical type (HR = 7.970, 0.009), leukocytosis 3.408, 0.006), lymphopenia 0.817, 0.038) emerging as reduced survival. Critical-type demonstrated significantly elevated inflammatory markers (neutrophils: 10.41 ± 6.23 × 10 9 /L; CRP: 104.47 29.18 mg/L) coagulopathy (D-dimer: 5.21 2.34 μg/ml) compared non-critical cases. Deceased pronounced metabolic derangements, including hyperglycemia (9.81 2.07 mmol/L) hepatic dysfunction (ALP: 174.03 30.13 U/L). Conclusion We revealed features different types summarized in this paper. found that type, leukocyte, lymphocyte are risk affect time, which could be an early helpful marker improve management

Язык: Английский

Epidemiological and clinical characteristics of COVID-19 mortality: a retrospective study DOI Creative Commons
Yaohua Hu, You Lü, Jianzeng Dong

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 10, 2025

Background The global impact of SARS-CoV-2 and its associated coronavirus disease (COVID-19) has necessitated urgent characterization prognostic biomarkers. This study aimed to delineate the epidemiological clinical predictors mortality among hospitalized COVID-19 patients. Methods A retrospective cohort was conducted on 123 patients with laboratory-confirmed admitted Huoshenshan Hospital (Wuhan, China) from 1 February 2020 30 April 2020. Kaplan–Meier curve multivariate Cox regression were used assess independent factors survival time. Statistical significance set at a p -value <0.05. Results exhibited rate 49.6% (61/123), critical type (HR = 7.970, 0.009), leukocytosis 3.408, 0.006), lymphopenia 0.817, 0.038) emerging as reduced survival. Critical-type demonstrated significantly elevated inflammatory markers (neutrophils: 10.41 ± 6.23 × 10 9 /L; CRP: 104.47 29.18 mg/L) coagulopathy (D-dimer: 5.21 2.34 μg/ml) compared non-critical cases. Deceased pronounced metabolic derangements, including hyperglycemia (9.81 2.07 mmol/L) hepatic dysfunction (ALP: 174.03 30.13 U/L). Conclusion We revealed features different types summarized in this paper. found that type, leukocyte, lymphocyte are risk affect time, which could be an early helpful marker improve management

Язык: Английский

Процитировано

0