Polymers,
Год журнала:
2024,
Номер
16(18), С. 2564 - 2564
Опубликована: Сен. 11, 2024
The
primary
objective
of
this
systematic
review
study
was
to
investigate
the
effectiveness,
durability,
and
adverse
events
PLLA
treatment
for
aesthetic
indications.
search
strategy
performed
in
MEDLINE
(Ovid).
electronic
literature
five
databases
performed,
from
inception
until
12th
February
2024.
This
identify
randomized
clinical
trials
that
assessed
adult
individuals
exhibiting
facial
aging
and/or
lipoatrophy.
Risk
bias
using
Cochrane
Risk-of-Bias
Tool
Randomized
Trials
(RoB
2).
Eleven
RCTs
out
1467
identified
citations
were
included.
Four
studies
showed
increased
dermal
thickness,
significant
improvement
lipoatrophy
severity
scores,
after
with
its
effects
sustained
at
least
25
months.
Two
demonstrated
superiority
over
injectable
human
collagen.
Also,
three
positive
results
favoring
when
compared
PH
gel
severity,
transepidermal
water
loss,
skin
quality,
elasticity,
patient
satisfaction.
All
mild-to-moderate
intensity,
main
ones
worth
noting
bruising,
hematoma,
tenderness,
nodules,
edema.
Five
eleven
considered
having
high
risk
bias.
evidence
on
effectiveness
safety
rejuvenation
is
low
quality;
thus,
reported
safety,
long-lasting
purpose
should
be
further
investigated.
Medicine,
Год журнала:
2024,
Номер
103(11), С. e37506 - e37506
Опубликована: Март 15, 2024
Poly-L-lactin
acid
(PLLA)
has
been
widely
used
in
the
field
of
bio-medicine.
In
2004,
as
an
injectable
material,
PLLA
was
approved
by
FDA
to
treat
AIDS-related
facial
atrophy.
Since
then,
several
stuffs
containing
have
for
marketing
various
countries
and
regions.
Recently,
often
rejuvenation
problems
like
cutaneous
depressions
static
wrinkles
which
always
induce
unsatisfactory
expression.
This
review
introduces
physicochemical
properties,
regeneration
stimulating
mechanism,
applications
aesthetics
comorbidity
PLLA.
Cosmetics,
Год журнала:
2023,
Номер
10(4), С. 110 - 110
Опубликована: Авг. 1, 2023
Dermal
fillers
have
gained
significant
attention
in
the
field
of
aesthetic
medicine
due
to
their
ability
restore
volume
and
correct
facial
wrinkles.
Even
though
such
formulations
similar
compositions,
they
can
different
microstructure
molecular
characteristics,
which
turn
affect
biodegradation
profile.
This
study
presents
results
an
investigation
physicochemical
characteristics
four
dermal
from
manufacturers
(Sculptra®,
Gana
V®,
AestheFill®,
Repart
PLA®).
The
supramolecular
polylactic
acid
(L/D
isomer
ratio,
weight,
degree
crystallinity),
morphology
size
PLA
microparticles
were
determined.
Hydrolytic
degradation
studies
phosphate
buffer
revealed
differences
rate
weight
reduction
polymer.
obtained
data
may
be
important
for
analysis
interpretation
biological
clinical
outcomes
fillers.
Cosmetics,
Год журнала:
2024,
Номер
11(2), С. 49 - 49
Опубликована: Март 31, 2024
The
growing
interest
in
maintaining
a
youthful
appearance
has
encouraged
an
accelerated
development
of
innovative,
minimally
invasive
aesthetic
treatments
for
facial
rejuvenation
and
regeneration.
close
correlation
between
tissue
repair,
regeneration,
aging
paved
the
way
application
regenerative
medicine
principles
cosmetic
dermatology.
theoretical
substrates
applications
dermo-aesthetics
are
plentiful.
However,
dermatology
is
emerging
field
needs
more
data
vivo
trials
to
reach
consensus
on
standardization
methods.
In
this
review,
we
summarize
techniques
as
they
apply
dermatology,
suggesting
unexplored
fields
future
directions.
Regenerative Biomaterials,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 1, 2023
Abstract
Materials
of
different
allogeneic
or
xenogeneic
autologous
origins
are
widely
used
as
soft-tissue
fillers
structural
scaffolds
in
the
field
cosmetic
surgery,
while
complications
including
prosthesis
infection,
donor
site
deformity
and
filler
embolization
have
always
been
difficult
problems
for
plastic
surgeons.
The
application
novel
biomaterials
may
bring
hopeful
solutions
these
problems.
Recently,
some
advanced
biomaterials,
such
regenerative
can
effectively
promote
repair
defective
tissues,
which
proven
to
good
therapeutic
well
effects
surgery.
Therefore,
with
active
compounds
drawn
significant
attention
tissue
regeneration
reconstructive
esthetic
treatment.
Some
applications
achieved
better
clinical
outcomes
than
traditional
biological
materials.
This
review
summarized
recent
progress
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(35), С. 8757 - 8766
Опубликована: Янв. 1, 2024
Schematic
representation
of
the
emulsification-crosslinking
strategy
for
constructing
collagen–chitosan
double-crosslinked
composite
microsphere
implants.
Primary Dental Journal,
Год журнала:
2023,
Номер
12(3), С. 65 - 72
Опубликована: Сен. 1, 2023
Dermal
filler
and
botulinum
toxin
injections
are
among
the
most
performed
non-invasive
procedures
for
rejuvenation
contouring,
internationally.
Although
dermal
fillers
approved
toxins
well
tolerated
with
a
high
safety
profile,
adverse
events
and/or
complications
can
happen.
Injection-related
sequelae
side
effects
usually
rare,
mild,
transient,
self-limiting
in
nature.
However,
devastating
life-changing
complications,
such
as
intravascular
occlusion,
skin
necrosis,
permanent
visual
impairment,
stroke,
have
been
reported.
Risk
reduction
measures
include
an
in-depth
knowledge
of
anatomy,
physiology,
pharmacology,
correct
patient
selection,
identification
clinical
indications,
and,
fundamentally,
importance
appropriate
skill
training.
In
this
paper,
some
discussed
advice
on
how
to
minimise
from
these
injectables
is
provided.
Journal of Cosmetic Dermatology,
Год журнала:
2023,
Номер
22(12), С. 3223 - 3231
Опубликована: Окт. 2, 2023
Abstract
Background
Injectable
poly‐L‐lactic
acid
(PLLA)
has
been
proven
safe
and
effective
with
numerous
medical
applications
for
more
than
25
years.
The
product
approved
in
over
40
countries
is
being
used
soft
tissue
augmentation
the
face
certain
body
parts.
With
increased
demand
subtle
natural‐looking
aesthetic
treatments
Asia‐Pacific
region,
there
also
a
heightened
need
consistent
preparation
treatment
methodologies
to
optimize
outcomes
Asian
patients.
Methods
of
evidence
literature,
clinical
data
presented
case
reports,
collective
experience
authors
are
reflected
these
consensus
recommendations,
which
take
under
consideration
availability
biostimulators
region.
Results
resulting
recommendations
include
patient
selection
assessment,
management
expectations,
appropriate
storage,
proper
injection
techniques
plans,
adverse
effects,
PLLA
combination
other
facial
rejuvenation
procedures,
constructive
considerations.
Conclusions
In
above
shared
their
best
practices
accordance
updated
protocols
PLLA.
These
represent
real‐world
utilized
by
providing
Aesthetic Surgery Journal,
Год журнала:
2023,
Номер
43(7), С. NP531 - NP540
Опубликована: Янв. 17, 2023
Recent
research
has
indicated
that
in
the
upper
face
a
delicate
arrangement
exists
between
muscles
of
facial
expression
and
skin.
This
allows
for
immediate
transmission
movements
following
muscle
contraction,
resulting
skin
rhytid
formation.To
investigate
age-related
changes
biomechanical
unit
formed
by
muscles,
their
connective
tissue
envelope,
face.A
total
76
Caucasian
volunteers
(30
males,
46
females)
with
mean
age
42.2
years
(SD
18.6)
body
mass
index
24.58
kg/m2
3.7)
were
investigated.
Three
regions
analyzed
firmness
elasticity
cutometric
assessment,
vertical
horizontal
vector
displacement
using
3-dimensional
imaging,
activity
surface-derived
electromyography.Study
participants
older
(>42.2
years),
when
compared
younger
(≤42.2
showed
increased
firmness,
at
0.20
mm
vs
0.30
(P
<
.001);
decreased
53.2%
69.0%
(not
horizontal)
mobility
3.56
1.35
electromyography
(sEMG)
signal
frontalis
174
µV
309
=
.039).This
study
reveals
occur
each
component
face.
Knowledge
understanding
such
can
allow
more
targeted
individualized
surgical
nonsurgical
aesthetic
treatments.
Polymers,
Год журнала:
2024,
Номер
16(5), С. 573 - 573
Опубликована: Фев. 20, 2024
The
development
of
injectable
hydrogels
with
natural
biopolymers
such
as
gelatin
(Ge)
and
hyaluronic
acid
(Ha)
is
widely
performed
due
to
their
biocompatibility
biodegradability.
combination
both
polymers
crosslinked
N-Ethyl-N′-(3-dimethyl
aminopropyl)
carbodiimide
hydrochloride
(EDC)
can
be
used
an
innovative
dermal
filler
that
stimulates
fibroblast
activity
increases
skin
elasticity
tightness.
Thus,
Ge/Ha
different
concentrations
EDC
were
administered
subcutaneously
test
efficacy
in
young
old
rats.
At
higher
concentrations,
the
viscosity
decreases
while
particle
size
increases.
all
EDC,
amino
carboxyl
groups
are
present.
histological
analysis
shows
acute
inflammatory
response,
which
disappears
seven
days
after
application.
one
three
months
post-treatment,
no
remains
found,
number
fibroblasts
comparison
control.
In
addition,
elastic
modulus
treatment.
Because
EDC-crosslinked
biocompatible
induce
increased
tension,
proliferation,
de
novo
extracellular
matrix
production,
we
propose
use
a
treatment
attenuate
wrinkles
expression
lines.
International Journal of Dermatology,
Год журнала:
2024,
Номер
63(7), С. 881 - 889
Опубликована: Фев. 23, 2024
A
filler
composed
of
calcium
hydroxylapatite
and
carboxymethylcellulose
gel
(CaHA/CMC)
has
been
shown
to
possess
biostimulatory
skin-tightening
properties
that
have
applied
not
just
the
face
but
also
body
boost
rejuvenation.
Recently,
evidence
recommendations
for
CaHA/CMC
treatment
provided,
they
are
still
lacking
in
terms
treatment.
This
article
aims
perform
a
systematic
review
literature
on
applications
provide
from
literature.
Currently,
only
FDA-approved
indication
is
treating
hands
recent
European
Union
Medical
Device
Regulation
approval
released
decolletage
The
application
hyperdilutions
neck,
feet,
arms,
thighs,
abdomen,
other
parts
proven
effect.
However,
despite
their
wide
use
with
good
safety
profile
clinical
practice,
trends
guidelines
diluted
hyperdiluted
yet
be
supported
by
randomized
controlled
trials.
