Polymers,
Год журнала:
2024,
Номер
16(18), С. 2564 - 2564
Опубликована: Сен. 11, 2024
The
primary
objective
of
this
systematic
review
study
was
to
investigate
the
effectiveness,
durability,
and
adverse
events
PLLA
treatment
for
aesthetic
indications.
search
strategy
performed
in
MEDLINE
(Ovid).
electronic
literature
five
databases
performed,
from
inception
until
12th
February
2024.
This
identify
randomized
clinical
trials
that
assessed
adult
individuals
exhibiting
facial
aging
and/or
lipoatrophy.
Risk
bias
using
Cochrane
Risk-of-Bias
Tool
Randomized
Trials
(RoB
2).
Eleven
RCTs
out
1467
identified
citations
were
included.
Four
studies
showed
increased
dermal
thickness,
significant
improvement
lipoatrophy
severity
scores,
after
with
its
effects
sustained
at
least
25
months.
Two
demonstrated
superiority
over
injectable
human
collagen.
Also,
three
positive
results
favoring
when
compared
PH
gel
severity,
transepidermal
water
loss,
skin
quality,
elasticity,
patient
satisfaction.
All
mild-to-moderate
intensity,
main
ones
worth
noting
bruising,
hematoma,
tenderness,
nodules,
edema.
Five
eleven
considered
having
high
risk
bias.
evidence
on
effectiveness
safety
rejuvenation
is
low
quality;
thus,
reported
safety,
long-lasting
purpose
should
be
further
investigated.
International Journal of Dermatology,
Год журнала:
2024,
Номер
63(7), С. 881 - 889
Опубликована: Фев. 23, 2024
A
filler
composed
of
calcium
hydroxylapatite
and
carboxymethylcellulose
gel
(CaHA/CMC)
has
been
shown
to
possess
biostimulatory
skin-tightening
properties
that
have
applied
not
just
the
face
but
also
body
boost
rejuvenation.
Recently,
evidence
recommendations
for
CaHA/CMC
treatment
provided,
they
are
still
lacking
in
terms
treatment.
This
article
aims
perform
a
systematic
review
literature
on
applications
provide
from
literature.
Currently,
only
FDA-approved
indication
is
treating
hands
recent
European
Union
Medical
Device
Regulation
approval
released
decolletage
The
application
hyperdilutions
neck,
feet,
arms,
thighs,
abdomen,
other
parts
proven
effect.
However,
despite
their
wide
use
with
good
safety
profile
clinical
practice,
trends
guidelines
diluted
hyperdiluted
yet
be
supported
by
randomized
controlled
trials.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 31, 2024
Objective
Injectable
skin
fillers
offer
a
wider
range
of
options
for
cutaneous
anti-aging
and
facial
rejuvenation.
PLLA
microspheres
are
increasingly
favored
as
degradable
long-lasting
fillers.
The
present
study
focused
solely
on
the
effect
dermal
collagen,
without
investigating
its
impact
epidermis.
In
this
study,
we
investigated
effects
epidermal
stem
cells
(EpiSCs).
Methods
Different
concentrations
(EpiSCs)
in
vitro
through
culture,
identification
primary
rat
EpiSCs.
CCK-8
detection,
apoptosis
staining,
flow
cytometry,
Transwell
assay,
wound
healing
q-PCR
analysis,
immunofluorescence
staining
were
used
to
detect
Furthermore,
observed
epidermis
by
injecting
into
dermis
vivo
.
Results
promote
cell
proliferation
migration
while
delaying
senescence
maintaining
stemness.
vitro,
Intradermal
injection
back
resulted
delayed
aging,
evidenced
histological
immunohistochemical
at
2,
4,
12
weeks
follow-up.
Conclusion
This
showed
positive
EpiSCs,
providing
novel
insights
mechanism
PLLA.
Plastic & Reconstructive Surgery Global Open,
Год журнала:
2025,
Номер
13(1), С. e6482 - e6482
Опубликована: Янв. 1, 2025
Injection
cosmetic
procedures
have
shown
rapid
continuing
growth
in
the
last
2
decades.
Various
substances
are
injected
into
periorbital
region
for
skin
quality
increase
and
correction
of
tear
trough
deformity,
including
hyaluronic
acid,
peptides,
collagen,
others.
Sometimes
patients
get
accidentally
with
different
that
not
approved
treatment
this
anatomic
area.
The
author
presents
a
case
51-year-old
woman,
unknown
oil
solution
lower
eyelid
by
local
dermatologist.
Inflammation
induration
occurred
after
these
injections.
patient
was
treated
conservatively
until
acute
process
stopped,
then
surgical
performed
to
correct
orbicularis
oculi
muscle
changes.
Surgical
included
direct
cyst
excision
removal
injection
changed
tissues
between
muscle.
observed
scheduled
appointments
conservative
prevent
unfavorable
scar
formation
deformity.
Although
kinds
injections
purposes,
accidental
occur
may
lead
terrible
results.
Methods
deformity
presented
literature.
In
article,
report
method
soft
eyelids
occurring
cases
like
rare,
they
require
provide
good
aesthetic
result
treatment.
Journal of Cosmetic Dermatology,
Год журнала:
2024,
Номер
23(8), С. 2556 - 2562
Опубликована: Март 28, 2024
Tear
trough-eye
bag
deformities
may
appear
in
young
Asian
patients
due
to
the
weak
support
of
their
facial
skeletons.
For
these
with
better
periorbital
skin
elasticity,
injection
be
more
suitable
than
surgery
for
treating
tear
trough-lower
eyelid
deformity.
Materials Today Bio,
Год журнала:
2024,
Номер
28, С. 101210 - 101210
Опубликована: Авг. 28, 2024
Skin
aging
is
the
phenomenon
of
degenerative
changes
in
structure
and
function
skin
tissues
over
time
manifested
by
a
gradual
loss
elasticity
firmness,
an
increased
number
wrinkles,
hyperpigmentation.
anti-aging
refers
to
reduction
through
medical
cosmetic
technologies.
In
recent
years,
new
biomaterials
have
been
continuously
developed
for
improving
appearance
mechanical
tissue
filling,
regulating
collagen
synthesis
degradation,
inhibiting
pigmentation,
repairing
barrier.
This
review
summarizes
mechanisms
associated
with
aging,
describes
that
are
commonly
used
aesthetics
their
possible
modes
action,
discusses
application
strategies
this
area.
Moreover,
synergistic
effects
such
other
active
ingredients,
as
stem
cells,
exosomes,
growth
factors,
antioxidants,
on
regeneration
evaluated.
Finally,
challenges
development
prospects
field
discussed,
novel
ideas
future
innovations
area
summarized.
Journal of Cosmetic Dermatology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Background
Acne
is
a
common
condition
observed
in
adolescents
and
most
severe
acne
the
scars
develop.
There
are
numerous
treatment
options
for
scars.
However,
no
standardized
guidelines
have
been
established
to
guide
physicians
optimal
of
Aims
The
objective
this
systematic
review
evaluate
existing
evidence
on
various
fillers
used
compare
their
effectiveness
with
one
another.
Methods
study
was
designed
following
PRISMA
guidelines,
information
retrieved
May
2024
using
PubMed
database
ClinicalTrials.gov
registry.
inclusion
criteria
were
that
studies
involving
patients
any
age
or
gender
type
treated
synthetic
dermal
fillers,
published
English.
exclusion
less
than
10
participants
did
not
use
fillers.
To
assess
risk
bias
included
studies,
Cochrane
Collaboration's
Risk
Bias
tool
randomized
controlled
trials,
observational
Newcastle–Ottawa
Scale
used.
Results
Twenty‐six
total
1121
participants.
Fourteen
evaluated
HA
372
subjects,
five
focused
PMMA
305
four
CaHA
392
two
PLLA
42
PCL
subjects.
Conclusions
Most
low
quality,
as
indicated
by
scores
quality
assessments,
lack
high‐quality
RCTs,
small
sample
sizes.
Future
research
should
focus
conducting
randomized,
controlled,
split‐face
an
adequate
number
detailed
examination
different
scar
subtypes.
Polymers,
Год журнала:
2025,
Номер
17(5), С. 638 - 638
Опубликована: Фев. 27, 2025
Skin
aging
is
a
complex
and
multifactorial
process
influenced
by
both
intrinsic
extrinsic
factors.
The
periorbital
area
of
the
face
particularly
susceptible
to
premature
signs
due
its
delicate
skin
structure,
major
concern
for
many
individuals.
While
hyaluronic
acid
(HA)-based
dermal
filler
products
are
commonly
used
rejuvenation,
novel
approaches
effectively
locally
address
visible
available.
This
study
aimed
investigate
Innovyal
Regenerative
Action
(IRA),
an
injectable
polynucleotide-HA
(PN-HA)
regenerative
designed
periocular
prejuvenation.
Firstly,
PN-HA
was
compared
other
commercially
available
HA-based
dermbooster
(Profhilo®,
Suisselle
Cellbooster®
Glow,
NCTF®
135
HA)
in
terms
rheological
properties,
vitro
antioxidant
capacity,
total
collagen
production
stimulation
human
fibroblasts.
Secondly,
clinical
effects
IRA
were
evaluated
two
case
reports
(monotherapy
prejuvenation).
It
shown
that
outperformed
comparators
relative
behavior
(biophysical
attributes
normalized
polymer
contents),
activity
(CUPRAC,
FRAP,
ORAC
assays),
as
well
level
induction
(72-h
fibroblast
model).
Generally,
results
this
provided
mechanistic
preliminary
insights
into
potential
benefits
cutaneous
treatment.
Overall,
it
underscored
combining
structural
support
properties
PN
with
hydrating
volumizing
HA
bares
tangible
quality
enhancement
prejuvenation
particular.
