Depression reduces cognitive function partly through effects on BMI and hypertension: a large observational study and Mendelian randomization analysis DOI Creative Commons

Hongyang Gong,

Zhao Wang, Yanyan Chen

и другие.

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 17, 2025

While abundant evidence suggests a correlation between depression and the risk of cognitive impairments, causal relationship, as well mechanisms mediating this association, remain uncertain. We conducted an observational study within National Health Nutrition Examination Survey (NHANES), simultaneously employing weighted multivariable-adjusted linear regression to explore association them. Subsequently, Mendelian randomization analysis was employed investigate relationship them effects. The NHANES data indicates that is independently associated with function. Regarding MR, genetically predicted causally related function in IVW method (OR 0.33, 95% CI 0.14-0.78, P = 0.012). Furthermore, leads obesity 1.91, 2.53 × 10 - 3) elevated blood pressure 2.34, 3.62 3). Waist circumference 0.85, 3.00 4), BMI 0.84, 1.06 6), hypertension 0.95, 4.00 all contribute Additionally, there no 1.00, 0.99-1.01, 0.559) reverse randomization. Mediation mediate 9.9% 3.6% under conditions, respectively. Our can lead hypertension, which reduce These findings underscore importance timely identification management patients impairments suggest treatments aimed at reducing weight lowering may help prevent impairment.

Язык: Английский

Depression reduces cognitive function partly through effects on BMI and hypertension: a large observational study and Mendelian randomization analysis DOI Creative Commons

Hongyang Gong,

Zhao Wang, Yanyan Chen

и другие.

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 17, 2025

While abundant evidence suggests a correlation between depression and the risk of cognitive impairments, causal relationship, as well mechanisms mediating this association, remain uncertain. We conducted an observational study within National Health Nutrition Examination Survey (NHANES), simultaneously employing weighted multivariable-adjusted linear regression to explore association them. Subsequently, Mendelian randomization analysis was employed investigate relationship them effects. The NHANES data indicates that is independently associated with function. Regarding MR, genetically predicted causally related function in IVW method (OR 0.33, 95% CI 0.14-0.78, P = 0.012). Furthermore, leads obesity 1.91, 2.53 × 10 - 3) elevated blood pressure 2.34, 3.62 3). Waist circumference 0.85, 3.00 4), BMI 0.84, 1.06 6), hypertension 0.95, 4.00 all contribute Additionally, there no 1.00, 0.99-1.01, 0.559) reverse randomization. Mediation mediate 9.9% 3.6% under conditions, respectively. Our can lead hypertension, which reduce These findings underscore importance timely identification management patients impairments suggest treatments aimed at reducing weight lowering may help prevent impairment.

Язык: Английский

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