Sleep Medicine Clinics, Год журнала: 2022, Номер 17(2), С. 241 - 252
Опубликована: Июнь 1, 2022
Язык: Английский
Lighting Research & Technology, Год журнала: 2017, Номер 50(1), С. 38 - 62
Опубликована: Июль 25, 2017
In addition to stimulating the visual system, light incident on retina stimulates other biological functions, also referred as non-visual responses. Among most notable functions are human circadian rhythms, which bodily rhythms that, in constant darkness, oscillate with a period close to, but typically slightly longer than 24 hours. Twenty-four-hour light-dark patterns major synchronizer of local time Earth. Entrainment has been implicated health and well-being. Light can elicit an acute alerting effect people, similar "cup coffee." This review summarizes literature how affects entrainment alertness it be used achieve these aims.
Язык: Английский
Процитировано
127
Dementia and Geriatric Cognitive Disorders, Год журнала: 2018, Номер 46(5-6), С. 371 - 384
Опубликована: Янв. 1, 2018
<b><i>Background:</i></b> Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer’s disease (AD) patients. Recently, handful of studies also focused on the effect cognition behavior. Conflicting findings are reported literature, no definite conclusions have been drawn about its specific effect. <b><i>Summary:</i></b> The aim this review provide critical evaluation available evidence field, highlighting characteristics effective bright treatment. Eligible were required assess at least one following outcome measures: sleep, cognition, mood, and/or behavior (e.g., depression, agitation). A total 32 articles included systematic identified as research AD. quality papers was evaluated based US Preventive Service Task Force guidelines. <b><i>Key Messages:</i></b> Overall, current literature suggests that effects AD patients mixed may be influenced by several factors, but with general trend toward positive seems promising without significant adverse effects; therefore, further well-designed randomized controlled trials needed taking into account highlighted recommendations.
Язык: Английский
Процитировано
115
Lighting Research & Technology, Год журнала: 2020, Номер 53(2), С. 97 - 118
Опубликована: Окт. 6, 2020
This paper discusses the rise of human-centric lighting and its current status in lighting. We summarise human benefits associated with light show that has sound motivations, despite being tainted by misleading marketing claims. The phrase integrative avoids hype encapsulates what aspires to be. Embodied these concepts are some things old new. is twofold. First, without diminishing value products, core ingredient for good outcomes design, driven a design team. Second, still vision, visibility, visual comfort amenity as important ever. Complementing new awareness responsibility how influence non-visual responses humans. Circadian, neuroendocrine neurobehavioural health should be considered on-par responses. leads toward solutions increased contrast between day night. parties responsible addressing evolving. Architects, professionals, equipment manufacturers, medical building owners individuals all have stake, but who drive decisions proportion?
Язык: Английский
Процитировано
111
Journal of Alzheimer s Disease, Год журнала: 2016, Номер 52(1), С. 303 - 315
Опубликована: Апрель 26, 2016
The objective of this study was to compare the effects a multisensory stimulation environment (MSSE) and individualized music sessions on agitation, emotional cognitive status, dementia severity in sample institutionalized patients with severe dementia. Twenty-two participants diagnosis or very were randomly assigned two groups: MSSE sessions. Both groups participated 30-min weekly over 16 weeks. Outcomes agitation (Cohen-Mansfield Agitation Inventory, CMAI), mood (Cornell Scale for Depression Dementia, CSDD), anxiety (Rating Anxiety RAID), function (Severe Mini-Mental State Examination, SMMSE), overall (Bedford Alzheimer Nursing Severity Scale, BANS-S). They assessed at baseline (pre-trial), middle (mid-trial), end intervention (post-trial), 8 weeks after (follow-up). Patients group showed significant improvement their RAID BANS-S scores compared post- versus pre-trial. With regard there during both CMAI total score intervention, no differences between groups. results suggest that could have better symptoms comparison elderly
Язык: Английский
Процитировано
108
Journal of Clinical Sleep Medicine, Год журнала: 2019, Номер 15(12), С. 1757 - 1767
Опубликована: Дек. 13, 2019
We investigated the effectiveness of a lighting intervention tailored to maximally affect circadian system as nonpharmacological therapy for treating problems with sleep, mood, and behavior in persons Alzheimer disease related dementias (ADRD).
Язык: Английский
Процитировано
104
Nature and Science of Sleep, Год журнала: 2016, Номер unknown, С. 21 - 21
Опубликована: Янв. 1, 2016
Abstract: Sleep and circadian disorders in Alzheimer's disease (AD) are more frequent than the general population appear early course of disease. Quality sleep quality life parallel these patients, such also represent a heavy burden for caregivers. Although alterations melatonin hypocretins (orexins) seem to play key role origin disturbances, etiology is multifactorial, including many factors as environment, behavior, treatments, comorbidities, among others. A comprehensive evaluation each patient essential design treatment that includes nonpharmacological pharmacological approaches. One particularly interesting point possibility pathogenesis AD, raising treating disorder may alter In this review, we present an update on bidirectional influence problems options. Behavioral measures, bright light therapy (BLT), melatonin, other drugs likely well known correctly managed by physicians charge patients. spite multiple treatments used, evidence efficacy scarce randomized double-blind placebo-controlled studies needed. Future directions establishment BLT protocols development with new mechanisms action, especially hypocretin receptor antagonists, agonists, molecules modulate clock. Keywords: Alzheimer disease, disorders, rhythm
Язык: Английский
Процитировано
102
Current Treatment Options in Neurology, Год журнала: 2016, Номер 18(9)
Опубликована: Июль 30, 2016
Язык: Английский
Процитировано
100
Pain, Год журнала: 2016, Номер 158(2), С. 347 - 360
Опубликована: Ноя. 19, 2016
Abstract Treatments for chronic pain are inadequate, and new options needed. Nonpharmaceutical approaches especially attractive with many potential advantages including safety. Light therapy has been suggested to be beneficial in certain medical conditions such as depression, but this approach remains explored modulation of pain. We investigated the effects light-emitting diodes (LEDs), visible spectrum, on acute sensory thresholds naive rats well experimental neuropathic Rats receiving green LED light (wavelength 525 nm, 8 h/d) showed significantly increased paw withdrawal latency a noxious thermal stimulus; antinociceptive effect persisted 4 days after termination last exposure without development tolerance. No apparent side were noted motor performance was not impaired. Despite exposure, opaque contact lenses prevented antinociception. fitted exposed room exhibited antinociception arguing role visual system. Antinociception due stress/anxiety likely enkephalins expression spinal cord. Naloxone reversed antinociception, suggesting involvement central opioid circuits. Rostral ventromedial medulla inactivation light-induced engagement descending inhibition. Green also mechanical hyperalgesia nerve ligation. Pharmacological proteomic profiling dorsal root ganglion neurons from LED-exposed identified changes calcium channel activity, decrease N-type (CaV2.2) channel, primary analgesic target. Thus, may represent novel, nonpharmacological managing
Язык: Английский
Процитировано
98
Frontiers in Neurology, Год журнала: 2017, Номер 8
Опубликована: Май 4, 2017
There is increasing awareness on the role played by circadian rhythm abnormalities in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. The characterization of dysfunction parallels mounting evidence that hallmarks neurodegeneration also affect retina frequently lead to loss retinal ganglion cells different degrees optic neuropathy. In cell population there subgroup intrinsically photosensitive expressing photopigment melanopsin (mRGCs), which are now well known drive entrainment rhythms light-dark cycles. Thus, correlation between pathological changes affecting mRGCs with imbalance these diseases clearly emerging, pointing possibility patients might be amenable benefit from light therapy. Currently, this connection better established for disease, but same scenario may apply other disorders, Huntington's This review highlights similarities differences retinal/circadian axis posing a working frame future studies.
Язык: Английский
Процитировано
96
Frontiers in Neurology, Год журнала: 2021, Номер 12
Опубликована: Янв. 27, 2021
At its best, human-centric lighting considers the visual and non-visual effects of light in support positive human outcomes. worst, it is a marketing phrase used to healthwash products or design solutions. There no doubt that environmental contributes health, but how might one practice given both credible potential implausible hype? Marketing literature filled with promises. Technical societies have summarized science not yet offered guidance. Meanwhile, designers are middle, attempting distinguish knowledge from which dubious make decisions affect people directly. This article intended to: (1) empower reader fundamental understandings ways affects health; (2) provide process for can dovetail decision-making already part designer's workflow.
Язык: Английский
Процитировано
95