International Journal of Electrochemical Science,
Год журнала:
2023,
Номер
18(5), С. 100045 - 100045
Опубликована: Фев. 25, 2023
The
aim
of
this
work
was
performed
for
design
the
electrochemical
biosensor
(βg-GOx/MnO2
NPs/MB-CS/GCE)
determination
β-glucan
in
morel
samples
by
modification
glassy
carbon
electrode
(GCE)
with
electrodeposition
methylene
blue-chitosan
(MB-CS)
nanocomposite
and
MnO2
nanoparticles
(MnO2
NPs)
immobilization
β-glucanase
glucose
oxidase
(βg-GOx),
respectively.
study
morphology
NPs/MB–CS/GCE
FE-SEM
indicated
that
electrodeposited
NPs
chitosan
layer
are
wrapped
MB
nanocubes.
properties
nonconductive
enzyme
film
were
successfully
immobilized
β-glucan/MnO2
NPs/MB-CS/GCE,
synergetic
advantageous
effect
MB-CS
enhanced
sensitivity
selectivity
biosensor.
linear
range
0–
10,400
ng/mL
obtained,
0.00441
µA/ng.mL−1
detection
limit
0.34
determined.
on
applicability
βg-GOx/MnO2
as
sensor
revealed
significant
conformity
between
results
amperometric
β-Glucan
Assay
Kit
assays,
obtained
good
recoveries
90.00%
97.50%
relative
standard
deviation
less
than
5.18%
analysis
acceptable,
confirming
appropriate
content
fungal
samples.
Biomechanics and Modeling in Mechanobiology,
Год журнала:
2023,
Номер
22(4), С. 1193 - 1207
Опубликована: Март 22, 2023
Abstract
One
of
the
effective
treatment
options
for
intracranial
aneurysms
is
stent-assisted
coiling.
Though,
previous
works
have
demonstrated
that
stent
usage
would
result
in
deformation
local
vasculature.
The
effect
simple
on
blood
hemodynamics
still
uncertain.
In
this
work,
hemodynamic
features
stream
four
different
ICA
aneurysm
with/without
interventional
are
investigated.
To
estimate
relative
impacts
vessel
deformation,
distinctive
simulated
by
one-way
FSI
technique.
Four
factors
velocity,
wall
pressure
and
WSS
compared
peak
systolic
stage
to
disclose
impact
defamation
two
conditions.
decrease
almost
all
mentioned
parameters,
except
OSI.
Stenting
reduces
neck
inflow
rate,
while
was
not
consistent
among
aneurysms.
an
has
a
strong
influence
aneurysm.
This
outcome
ignored
most
preceding
investigations,
which
focused
pre-interventional
state
studying
relationship
between
stents.
Present
results
show
application
without
coiling
improve
factors,
especially
when
high
enough.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Фев. 19, 2023
The
rupture
of
the
aneurysm
wall
is
highly
associated
with
hemodynamic
feature
bloodstream
as
well
geometrical
aneurysm.
Coiling
known
most
conventional
technique
for
treatment
intracranial
cerebral
aneurysms
(ICA)
in
which
blood
stream
obstructed
from
entering
sac
In
this
study,
comprehensive
efforts
are
done
to
disclose
impacts
coiling
on
progress
and
risk
rupture.
computational
fluid
dynamic
method
used
analysis
hemodynamics
specific
ICA.
pulsatile
high-risk
region
also
explained.
Wall
shear
Stress
(WSS)
Oscillatory
index
(OSI)
factors
compared
different
viscosities
conditions.
According
our
hematocrit
test
(Hct)
effect
evident
(25%
reduction
maximum
WSS)
two
first
stages
(maximum
acceleration
peak
systolic).
Our
findings
present
that
porosity
0.89
0.79
would
decrease
WSS
by
about
8%
both
HCT
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 3461 - 3473
Опубликована: Апрель 1, 2024
Purpose:
Ivosidenib
(IVO),
an
isocitrate
dehydrogenase-1
(IDH1)
used
for
treatment
of
acute
myeloid
leukemia
(AML)
and
cholangiocarcinoma.However,
poor
solubility,
low
bioavailability,
high
dose
side
effects
limit
clinical
application
IVO.Methods:
Ivosidenib-loaded
PLGA
nanoparticles
(IVO-PLGA-NPs)
chitosan
coated
(IVO-CS-PLGA-NPs)
were
prepared
using
emulsification
solvent
evaporation
method
the
liver
cancer.
Results:The
developed
IVO-PLGA-NPs
evaluated
their
particle
size
(171.7±4.9
nm),
PDI
(0.333),
ZP
(-23.0±5.8
mV),
EE
(96.3±4.3%),
DL
(9.66±1.1%);similarly,
IVO-CS-PLGA-NPs
(177.3±5.2
(0.311),
+25.9±5.7
mV,
(90.8±5.7%),
(9.42±0.7%).The
coating
was
evidenced
by
increase
in
mean
positive
value.Because
coating,
showed
a
more
stable
prolonged
release
IVO
than
IVO-PLGA-NPs.In
comparison
to
pure-IVO,
found
be
effective
against
HepG2
cells,
with
IC
50
values
MTT
assay
being
approximately
half
those
pure-IVO.In
expressions
caspase-3,
caspase-9,
p53
significantly
(p
<
0.05)
elevated.Conclusion:
Overall,
these
findings
suggest
that
improves
delivery
efficacy
ivosidenib
cancer
treatment.
