Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1933 - 1933
Опубликована: Фев. 5, 2024
The
respiratory
mucus,
a
viscoelastic
gel,
effectuates
primary
line
of
the
airway
defense
when
operated
by
mucociliary
clearance.
In
chronic
diseases
(CRDs),
such
as
asthma,
obstructive
pulmonary
disease
(COPD),
and
cystic
fibrosis
(CF),
mucus
is
overproduced
its
solid
content
augments,
changing
structure
properties
determining
derangement
essential
mechanisms
against
opportunistic
microbial
(virus
bacteria)
pathogens.
This
ensues
in
damaging
airways,
leading
to
vicious
cycle
obstruction
infection
responsible
for
harsh
clinical
evolution
these
CRDs.
Here,
we
review
features
normal
pathological
(i.e.,
sputum
CF,
COPD,
asthma),
i.e.,
mucin
content,
(mesh
size),
micro/macro-rheology,
pH,
osmotic
pressure,
ending
with
awareness
that
biomarkers
(mucins,
inflammatory
proteins
peptides,
metabolites)
might
serve
indicate
acute
exacerbation
response
therapies.
There
are
some
indications
old
novel
treatments
may
change
structure,
properties,
biomarker
sputum;
however,
wealth
work
still
needed
embrace
measures
correlates
severity
association
(or
even
substitutes
of)
functional
tests.
Язык: Английский
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease
Expert Review of Molecular Diagnostics,
Год журнала:
2024,
Номер
24(5), С. 409 - 421
Опубликована: Апрель 18, 2024
Chronic
obstructive
pulmonary
disease
(COPD)
accounts
for
545
million
people
living
with
chronic
respiratory
disorders
and
is
the
third
leading
cause
of
morbidity
mortality
around
world.
COPD
a
progressive
disease,
characterized
by
episodes
acute
worsening
symptoms
such
as
cough,
dyspnea,
sputum
production.
Язык: Английский
Proteomic Blood Profiles Obtained by Totally Blind Biological Clustering in Stable and Exacerbated COPD Patients
Cells,
Год журнала:
2024,
Номер
13(10), С. 866 - 866
Опубликована: Май 17, 2024
Although
Chronic
Obstructive
Pulmonary
Disease
(COPD)
is
highly
prevalent,
it
often
underdiagnosed.
One
of
the
main
characteristics
this
heterogeneous
disease
presence
periods
acute
clinical
impairment
(exacerbations).
Obtaining
blood
biomarkers
for
either
COPD
as
a
chronic
entity
or
its
exacerbations
(AECOPD)
will
be
particularly
useful
management
patients.
However,
most
earlier
studies
have
been
characterized
by
potential
biases
derived
from
pre-existing
hypotheses
in
one
more
their
analysis
steps:
some
only
targeted
molecules
already
suggested
knowledge,
and
others
had
initially
carried
out
blind
search
but
later
compared
detected
among
well-predefined
groups.
We
hypothesized
that
clinically
cluster
on
results
non-hypothesis-driven
wide
proteomic
would
determine
an
unbiased
grouping
patients,
potentially
reflecting
endotypes
and/or
characteristics.
To
check
hypothesis,
we
included
plasma
samples
24
stable
10
additional
patients
with
AECOPD,
healthy
controls.
The
were
analyzed
through
label-free
liquid
chromatography/tandem
mass
spectrometry.
Subsequently,
Scikit-learn
machine
learning
module
K-means
used
clustering
individuals
based
solely
profiles.
obtained
clusters
confronted
groups
at
end
entire
procedure.
our
unable
to
differentiate
individuals,
they
segregated
those
AECOPD
conditions
(sensitivity
80%,
specificity
79%,
global
accuracy,
79.4%).
Moreover,
proteins
involved
process
identify
associated
five
biological
processes:
inflammation,
humoral
immune
response,
coagulation,
modulation
lipid
metabolism,
complement
system
pathways.
Even
though
present
merit
external
validation,
suggest
blinded
approach
may
segregate
stability
both
setting
trials,
favoring
personalized
medicine
research.
Язык: Английский
ERS International Congress 2023: highlights from the Airway Diseases Assembly
ERJ Open Research,
Год журнала:
2023,
Номер
10(2), С. 00891 - 2023
Опубликована: Ноя. 30, 2023
In
this
review,
early
career
and
senior
members
of
Assembly
5
(Airway
Diseases,
Asthma,
COPD
Chronic
Cough)
present
key
recent
findings
pertinent
to
airway
diseases
that
were
presented
during
the
European
Respiratory
Society
International
Congress
2023
in
Milan,
Italy,
with
a
particular
focus
on
asthma,
COPD,
chronic
cough
bronchiectasis.
During
congress,
an
increased
number
symposia,
workshops
abstract
presentations
organised.
total,
739
abstracts
submitted
for
majority
these
by
members.
These
data
highlight
interest
group
respiratory
diseases.
Язык: Английский
Global Trends in Research Regarding Macrophages Associated with Chronic Obstructive Pulmonary Disease: A Bibliometric Analysis from 2011 to 2022
International Journal of COPD,
Год журнала:
2023,
Номер
Volume 18, С. 2163 - 2177
Опубликована: Окт. 1, 2023
Purpose:
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
prevalent
respiratory
condition
characterized
by
chronic
airway
inflammation,
where
macrophages
from
the
innate
immune
system
may
exert
pivotal
influence.
Our
study
aimed
to
summarize
present
state
of
knowledge
and
identify
focal
points
emerging
developments
regarding
associated
with
COPD
through
bibliometrics.
Methods:
Publications
research
on
January
1,
2011,
2022,
were
retrieved
Science
Citation
Index-Expanded
(SCI-E)
which
part
Web
database.
In
total,
1521
publications
analyzed
using
bibliometric
methodology.
VOSviewer
was
used
analyze
annual
publications,
countries,
institutions,
authors,
journals,
hotspots.
Results:
Based
analysis,
relating
tended
increase
2011
2022.
The
United
States
largest
producer
most
influential
country
in
this
field.
Research
during
past
decade
has
focused
inflammation
lungs.
Most
previous
studies
have
mainly
mechanisms
that
promote
initiation
progression
COPD.
Macrophage-related
oxidative
stress
immunity,
communication
between
epithelial
cells,
interventions
for
acute
exacerbations
become
focus
more
recent
will
hot
topic
future.
Conclusion:
Global
macrophage-associated
been
growing
rapidly
decade.
topics
field
gradually
shift
“inflammation”
“oxidative
stress”,
“epithelial-cells”,
“exacerbations”.
significance
coordinating
responses,
interacting
other
exhibiting
dysregulated
capacities
attracted
increasing
attention
pathogenesis.
adoption
new
technologies
provide
promising
comprehensive
understanding
specific
role
Keywords:
macrophages,
disease,
VOSviewer,
hotspots,
bibliometrix
Язык: Английский