Targeting regulated cell death pathways in cancers for effective treatment: a comprehensive review DOI Creative Commons
Ruchi Saxena,

Catherine F. Welsh,

You‐Wen He

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Ноя. 15, 2024

Cancer is a complex disease characterized by specific “mission-critical” events that drive the uncontrolled growth and spread of tumor cells their offspring. These are essential for advancement disease. One main contributors to these dysregulation cell death pathways—such as apoptosis, necroptosis, ferroptosis, autophagy, pyroptosis, cuproptosis, parthanatos and—allows cancer avoid programmed continue proliferating unabated. The different pathways in cancers provide useful targets treatment. This review examines recent progresses preclinical clinical development targeting dysregulated To develop effective therapies, it identify target mission-critical prevent from timely death. By precisely crucial events, researchers can therapies with maximum impact minimal side effects. A comprehensive understanding molecular cellular mechanisms underlying regulated will further highly personalized treatments.

Язык: Английский

Cell death pathways: molecular mechanisms and therapeutic targets for cancer DOI Creative Commons
Shaohui Wang, Sa Guo, Jing Guo

и другие.

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Сен. 1, 2024

Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.

Язык: Английский

Процитировано

12
Absence of Cysteine and Iron Chelation Induces Ferroptosis in Triple-Negative Breast Cancer Cells DOI Creative Commons

Manvi Agarwal Neeraj,

Junjeong Choi

Breast Cancer Basic and Clinical Research, Год журнала: 2025, Номер 19

Опубликована: Янв. 1, 2025

Background: Ferroptosis is a recently studied form of programmed cell death characterized by lipid peroxides accumulation in the cells. This process occurs when cell’s antioxidant capacity disturbed resulting inability to detoxify toxic peroxides. Two major components that regulate ferroptosis are cysteine and iron. Objective: study aimed determine effect deficiency iron chelation on triple-negative breast cancer (TNBC) lipid-enriched microenvironment. Design: The has laboratory-based experimental design. used MDA-MB-231 line various vitro culture systems investigate research question. Methods: For first part study, we subjected cells grow cysteine-absent adipocyte-conditioned media. In second half, treated with chelator, deferoxamine. BODIPY imaging western blot were carried out observe under 2 conditions. Results: results showed absence conditioned media was able reduce formation droplets, which increased greater access free fatty acids undergo oxidation, therefore inducing ferroptosis. On contrary, deferoxamine along erastin (ferroptosis-inducing drug), an increase content observed, later Conclusion: Our show alternative function deferoxamine, one regulating droplets other ferroptosis, although inhibitor same, respectively.

Язык: Английский

Процитировано

0
Ferroptosis in thyroid cancer: mechanisms, current status, and treatment DOI Creative Commons
Wenzhi Tian, Xi Su,

Chenchen Hu

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Янв. 23, 2025

Thyroid cancer (TC) represents the most prevalent malignancy within endocrine system. In recent years, there has been a marked global increase in incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into pathogenesis TC have identified significant association with ferroptosis, newly characterized form cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is accumulation lipid peroxides reactive oxygen species, culminating cellular damage death.Recent research elucidated connection between initiation, progression, treatment cancer. These findings underscore significance offer valuable insights development novel therapeutic strategies precise predictive markers. The unique mechanisms present opportunities for targeting treatment-resistant cancers. Consequently, regulation may emerge as target, potentially addressing limitations current treatments. Moreover, elucidating molecular underpinning facilitate identification biomarkers early detection prognostication. This review endeavors to synthesize extant knowledge regarding role examine potential implications, propose future trajectories enhance understanding clinical application ferroptosis.

Язык: Английский

Процитировано

0
Targeting ferroptosis: a promising approach for treating lung carcinoma DOI Creative Commons
Ziyang Wu, Tao Zhang, Wei Zhong

и другие.

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 29, 2025

Abstract Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies immunotherapies is commonly compromised by emergence drug resistance other factors, resulting in lack durable therapeutic benefits. Ferroptosis, distinct pattern cell death marked buildup iron-dependent lipid peroxides, has been shown to be novel potentially more effective treatment for lung carcinoma. However, mechanism regulatory network ferroptosis are exceptionally complex, many unanswered questions remain. In addition, research diagnosis cancer growing exponentially. Therefore, it necessary provide thorough summary latest advancements field ferroptosis. Here, we comprehensively analyze mechanisms underlying preconditions ferroptosis, defense system, associated molecular networks. potential strategies also highlighted. Targeting improves tumor enhances effectiveness drugs immunotherapies. These findings may shed fresh light management carcinoma, as well development related

Язык: Английский

Процитировано

0
Design, synthesis and biological evaluation of benzo[b]thiophene analogues as novel ferroptosis inhibitor that inhibit fibrosarcoma cell proliferation DOI

Hua Yang,

Mingmei Guo,

Sumeng Guan

и другие.

Bioorganic & Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 118089 - 118089

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Erianin triggers ferroptosis in colorectal cancer cells by facilitating the ubiquitination and degradation of GPX4 DOI
Yuting Zheng,

Yinli Zheng,

Haipeng Chen

и другие.

Phytomedicine, Год журнала: 2025, Номер 139, С. 156465 - 156465

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

0
Bioinformatics-based Prognosis Effect of Ferroptosis-related Genes on Gastric Cancer DOI
Tao Wang,

Ailan Zeng,

Lili Zhu

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

0
Caspase-independent cell death in lung cancer: from mechanisms to clinical applications DOI Creative Commons
Gaurav Gupta,

Vijaya Paul Samuel,

M M Rekha

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Caspase-independent cell death (CICD) has recently become a very important mechanism in lung cancer, particular, to overcome critical failure apoptotic that is common disease progression and treatment failures. The pathways involved CICD span from necroptosis, ferroptosis, mitochondrial dysfunction, autophagy-mediated death. Its potential therapeutic applications have been highlighted. Glutathione peroxidase 4 (GPX4) inhibition-driven ferroptosis drug resistance non-small cancer (NSCLC). In addition, necroptosis involving RIPK1 RIPK3 causes tumor modulation of immune responses the microenvironment (TME). Mitochondrial are for through metabolic redox homeostasis. Ferroptosis amplified by reactive oxygen species (ROS) lipid peroxidation cells, depolarization induces oxidative stress leads mitochondria-mediated autophagy, or mitophagy, results clearance damaged organelles under conditions, while this function also linked when dysregulated. role autophagy regulated ATG proteins PI3K/AKT/mTOR pathway dual: suppress sensitize cells therapy. A promising approach enhancing outcomes involves targeting mechanisms CICD, including inducing SLC7A11 inhibition, modulating ROS generation, combining inhibition with chemotherapy. Here, we review molecular underpinnings particularly on their transform treatment.

Язык: Английский

Процитировано

0
Targeting regulated cell death pathways in cancers for effective treatment: a comprehensive review DOI Creative Commons
Ruchi Saxena,

Catherine F. Welsh,

You‐Wen He

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Ноя. 15, 2024

Cancer is a complex disease characterized by specific “mission-critical” events that drive the uncontrolled growth and spread of tumor cells their offspring. These are essential for advancement disease. One main contributors to these dysregulation cell death pathways—such as apoptosis, necroptosis, ferroptosis, autophagy, pyroptosis, cuproptosis, parthanatos and—allows cancer avoid programmed continue proliferating unabated. The different pathways in cancers provide useful targets treatment. This review examines recent progresses preclinical clinical development targeting dysregulated To develop effective therapies, it identify target mission-critical prevent from timely death. By precisely crucial events, researchers can therapies with maximum impact minimal side effects. A comprehensive understanding molecular cellular mechanisms underlying regulated will further highly personalized treatments.

Язык: Английский

Процитировано

1