Connection between oral health and chronic diseases

MedComm, Год журнала: 2025, Номер 6(1)

Опубликована: Янв. 1, 2025

Chronic diseases have emerged as a paramount global health burden, accounting for 74% of mortality and causing substantial economic losses. The oral cavity serves critical indicator overall is inextricably linked to chronic disorders. Neglecting can exacerbate localized pathologies accelerate the progression conditions, whereas effective management has potential reduce their incidence mortality. Nevertheless, limited resources lack awareness often impede timely dental intervention, delaying optimal therapeutic measures. This review provides comprehensive analysis impact prevalent diseases-such diabetes mellitus, rheumatoid arthritis, cardiovascular disorders, respiratory diseases-on health, along with an exploration how changes in affect these conditions through both deterioration intervention mechanisms. Additionally, novel insights into underlying pathophysiological mechanisms governing relationships are presented. By synthesizing advancements, this aims illuminate complex interrelationship between while emphasizing urgent need greater collaboration practitioners general healthcare providers improve outcomes.

Язык: Английский

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Correlations of Salivary and Blood Glucose Levels among Six Saliva Collection Methods

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(7), С. 4122 - 4122

Опубликована: Март 30, 2022

Background: Saliva has been studied as a better indicator of disorders and diseases than blood. Specifically, the salivary glucose level is considered to be an diabetes mellitus (DM). However, saliva collection methods can affect level, thereby affecting correlation between blood glucose. Therefore, this study aims identify ideal method use determine population individual correlations levels in DM patients healthy controls. Finally, analysis stability conducted. Methods: This included 40 age-matched In fasting state, was collected using six methods, venous simultaneously from each participant, both samples were analyzed at same time oxidase peroxidase. A total 20 controls arbitrarily selected above participants for one week daily testing. The before after breakfast analyzed. 10 month testing analyze correlations. Results: Salivary higher methods. Compared with unstimulated saliva, stimulated had decreased increased flow. addition, parotid most correlated (R2 = 0.9153), ROC curve area 0.9316, which could accurately distinguish patients. it found that different quite different. average 0.83, 0.77. coefficient variation within 1 less 5%. Conclusion: Unstimulated highest used Meanwhile, relatively high stable breakfast. general, presents collecting replace blood-glucose detect DM, provides reference prediction DM.

Язык: Английский

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Perspectives for the use of the antidiabetic drug metformin as a strategy to slow biological aging and age-related diseases

Kazan medical journal, Год журнала: 2025, Номер 106(1), С. 105 - 116

Опубликована: Март 19, 2025

This review focuses on the use of antidiabetic drug metformin as one most studied geroprotective candidates with a well-established safety profile. The primary theories aging and development age-related diseases, such type 2 diabetes mellitus (T2DM) Alzheimer disease, well relationship between T2DM cognitive impairment, are reviewed. Metformin is hypothesized to improve function, mitigate severity anxiety, reduce risk developing disease. In addition, able decelerate process increase longevity in experiments mice rats. Despite being among frequently prescribed medications globally, ability cross blood-brain barrier distribute all brain regions, precise mechanisms underlying its effects remain unclear. Studies show that activate 5'-adenosine monophosphate-activated protein kinase, levels advanced glycation endproducts, restore mitochondrial function. Moreover, enhances autophagy exerts neuroprotective effect neural stem cells. findings numerous studies indicate has antioxidant anti-inflammatory properties.

Язык: Английский

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State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature

Journal of Clinical Medicine, Год журнала: 2021, Номер 10(22), С. 5383 - 5383

Опубликована: Ноя. 18, 2021

Diabetes mellitus (DM) is a global health problem, having recognized that in the next 20 years number of diabetic patients world will increase to 642 million. DM exerts enormous repercussions on general (especially derived from vascular, cardiac, renal, ocular, or neurological affectation). It entails addition high deaths directly related disease, as well care cost, estimated at $673 billion annually. Oral cavity found among all organs and systems affected course DM. Important pathologies are developed with higher prevalence, such periodontitis (PD), alterations salivary flow, fungal infections, oral cancer, potentially malignant disorders (OPMD). has been proven PD hinders metabolic control presence increases possibility for developing diabetes. Despite relevance these pathologies, knowledge primary physicians diabetes specialists about importance diabetics, dentists scarce non-existent. accepted correct management requires interdisciplinary teams, including dentists. In this critical review, existing evidence-degree preventive, clinical, diagnosis, prognosis, therapeutic aspects diseases occur significant frequency population extension.

Язык: Английский

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Oral dysbiosis and systemic diseases

Frontiers in Dental Medicine, Год журнала: 2022, Номер 3

Опубликована: Сен. 22, 2022

The aim of this mini review is to investigate the connection between oral microbiome dysbiosis and systemic diseases. Many conditions can have manifestations cause worsening in For example, uncontrolled type 2 diabetes has been associated with periodontal disease. Other inflammatory diseases or autoimmune may predispose mucositis, mucosal ulcers, xerostomia, higher susceptibility infections. This will outline common such as metabolic, cardiovascular, immunologic disorders they relate changes composition.

Язык: Английский

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Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury

Biochemical Pharmacology, Год журнала: 2022, Номер 203, С. 115168 - 115168

Опубликована: Июль 12, 2022

Pathological deterioration of mitochondrial function is increasingly linked with multiple degenerative illnesses as a mediator wide range neurologic and age-related chronic diseases, including those genetic origin. Several these diseases are rare, typically defined in the United States an illness affecting fewer than 200,000 people U.S. population, or about one 1600 individuals. Vision impairment due to dysfunction eye prominent feature evident numerous primary common pathophysiology many familiar ophthalmic disorders, macular degeneration, diabetic retinopathy, glaucoma retinopathy prematurity — collection syndromes, disorders significant unmet medical needs. Focusing on metabolic pathway mechanisms, possible roles cuproptosis ferroptosis retinal dysfunction, we shed light potential α-lipoyl-L-carnitine treating diseases. α-Lipoyl-L-carnitine bioavailable mitochondria-targeting lipoic acid prodrug that has shown protecting against degeneration photoreceptor cell loss indications.

Язык: Английский

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Association between metabolic control and oral health in children with type 1 diabetes mellitus

BMC Oral Health, Год журнала: 2022, Номер 22(1)

Опубликована: Ноя. 16, 2022

Type 1 diabetes mellitus is the most common chronic disease and can be reflected in oral cavity. The aim of this study was to analyze impact metabolic control on saliva, dental caries, plaque, gingival inflammation, cariogenic bacteria saliva.A case-control epidemiologic performed children with type (ages 10-15 years) separated into two groups: 34 good glycated hemoglobin (HbA1c < 7.5%) 46 poor > 7.5%). Oral status assessed using Decay, Missing, Filled Teeth index for permanent teeth (DMFT), plaque index. stimulated salivary flow rate measured, colonies Streptococcus mutans Lactobacillus saliva were determined. observed answered questions related their frequency brushing habits, visits parents' education. Mann-Whitney U Test, Chi-Square test Fisher's exact used statistical analyses. significance level set at p 0.05.The had significantly higher values DMFT index, more colonies, a risk than (p 0.001). no influence rates 0.05). majority both groups brushed once per day, they visited dentist only when necessary (61.3%). However, parents medium low levels education, without any significant difference between 0.05).The results indicate that have lower hygiene are potentially caries periodontal diseases, mainly disorder uncontrolled.

Язык: Английский

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Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

Nanomaterials, Год журнала: 2021, Номер 11(11), С. 2977 - 2977

Опубликована: Ноя. 5, 2021

Dental implants are used broadly in dental clinics as the most natural-looking restoration option for replacing missing or highly diseased teeth. However, implant failure is a crucial issue diabetic patients need of dentition restoration, particularly when lack osseointegration and immunoregulatory incompetency occur during healing phase, resulting infection fibrous encapsulation. Bio-inspired biomimetic materials, which can mimic characteristics natural elements, being investigated use industry. This review discusses different terms structural changes that enable antibacterial properties, drug delivery, immunomodulation, osseointegration. We subsequently summarize modification diabetes utilizing carbon nanomaterials, have been recently found to improve implants, including through anti-inflammatory capabilities, by offering delivery properties essential success implants.

Язык: Английский

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Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(9), С. 2651 - 2651

Опубликована: Май 9, 2022

Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with poor prognosis in other settings. Our aim was to describe the profile and of IE without DM analyze prognostic relevance DM-related organ damage. Methods. Retrospective analysis Spanish Registry (2008−2020). Results. The cohort comprises 5590 patients mean age 65.0 ± 15.5 years; 3764 (67.3%) were male. found 1625 (29.1%) 515 presented prevalence during first half study period 27.6% vs. 30.6% last half, p = 0.015. Patients higher in-hospital mortality than those (521 [32.1%] 924 [23.3%], < 0.001) one-year (640 [39.4%] 1131 [28.5%], 0.001). Among patients, damage (200 [38.8%] 321 [28.9%], (247 [48.0%] 393 [35.4%], Multivariate analyses showed an independent association (odds ratio [OR] 1.34, 95% confidence interval [CI]: 1.16−1.55, (OR 1.38, CI: 1.21−1.59, independently 1.37, 1.06−1.76, 0.015) 1.59, CI 1.26−2.01, Conclusions. among increasing already above 30%. prognosis, particularly case

Язык: Английский

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Comparative Determination of Mitochondrial Biomarkers and Their Relationship With Insulin Resistance in Type 2 Diabetic Patients: An Observational Cross‐Sectional Study

Endocrinology Diabetes & Metabolism, Год журнала: 2024, Номер 7(4)

Опубликована: Июнь 28, 2024

Data suggest malfunctioning mitochondria reduce oxidation and adenosine triphosphate (ATP) production, disrupting insulin signalling. Cytochrome c (CC), acylcarnitine (AC) citrate synthase (CS) are essential components of the machinery can be used as reliable biomarkers mitochondrial dysfunction. This study aimed to determine whether (AC, CS CC) altered in individuals with type 2 diabetes mellitus (T2DM) examine association between these resistance.

Язык: Английский

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