Journal of Integrative Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
0
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102713 - 102713
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Nutritional Neuroscience, Год журнала: 2025, Номер unknown, С. 1 - 26
Опубликована: Март 3, 2025
Background: Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant neuroprotective potential due to its diverse pharmacological properties.Objective: This review explores curcumin's role in modulating key pathological mechanisms underlying neurodegenerative disorders such as Alzheimer's, Parkinson's diseases, Amyotrophic Lateral Sclerosis, Huntington's Disease and Prion Disease.Methods: A comprehensive analysis of molecular interactions, including effects on amyloid-beta (Aβ) aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, metal-induced neurotoxicity, was conducted. Additionally, strategies overcome low bioavailability blood-brain barrier (BBB) permeability were evaluated.Results: Curcumin inhibits Aβ aggregation promotes disaggregation, reducing amyloid plaque formation Alzheimer's disease. It modulates glial cell activity, attenuating neuroinflammation fostering environment. By interacting with proteins, curcumin prevents hyperphosphorylation neurofibrillary tangle formation. As potent antioxidant, it scavenges reactive oxygen species, mitigating stress-related neuronal damage. Its metal-chelating properties further diminish neurotoxicity by sequestering iron copper ions. Despite limited BBB permeability, therapeutic efficacy can be enhanced using nanocarriers nanoparticles, liposomes, micelles, which improve solubility, stability, brain penetration.Conclusion: Curcumin's multifaceted make promising candidate for preventing or slowing disease progression. Advanced drug delivery systems hold overcoming pharmacokinetic limitations, paving the way future clinical applications.
Язык: Английский
Процитировано
0
Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)
Опубликована: Март 8, 2025
CNS diseases account for a major part of the comorbidity and mortality human population; moreover, neuroinflammation has become an indication different diseases, instance, Parkinson's Alzheimer's disease. Microglia astrocytes are two main glial cells that can be found in CNS. Each these plays important role mediating immune responses like inflammation. There many studies suggesting LncRNAs neuroinflammation. Indeed, orchestrate through various mechanisms, namely miRNA sponge, transcriptional activation/inhibition. In addition, regulate downstream pathways NF-κB, PI3K/AKT. this study, we gathered existing regarding mechanisms action pathogenesis neurodegenerative traumatic injuries regulating We aim to elaborate on regulatory roles bring more profound understanding etiology terms
Язык: Английский
Процитировано
0
BMC Neuroscience, Год журнала: 2025, Номер 26(1)
Опубликована: Март 10, 2025
Diazinon is a commonly used organophosphate (OP) insecticide especially in developing countries for the control of insect pests, however, exposure to its toxic impact humans and other non-target species remains an important public health concern. The study aimed investigate effect epigallocatechin -3- gallate (EGCG), abundant green tea plants on neurobehavioural, biochemical, pathological changes brain male Wistar rats following diazinon toxicity. Sixty adult were acclimatized seven days subsequently randomly assigned into six treatment groups as follows: Group I: Control group (0.2 mL distilled water); II: at 3 mg/kg (1% LD50); III: (3 mg/kg) + EGCG (50 mg/kg, ~ 2% IV: (100 5% V: VI: mg/kg). All treatments administered orally once daily 14 days. Neurobehavioural studies, biomarkers oxidative stress, histology, immunohistochemistry, quantitative polymerase chain reaction (RT qPCR) performed. alone impaired recognition memory, increased stress markers altered antioxidant defense brain. It upregulated TNF-α IL-6 genes repressed GPx 4 gene expressions. was also associated with GFAP, Tau, α-SN immunoreactivity. Microscopic examination revealed loss Purkinje hippocampal cells Co-treatment however improved cognition, lowered markers, status suppressed IL-6. In conclusion, findings from this demonstrated that offered protection against diazinon-induced neurotoxicity. Hence, natural sources such fruits vegetables could offer immense benefits by protecting inflammation neurodegenerative disease conditions. Clinical trial number Not applicable.
Язык: Английский
Процитировано
0
GeroScience, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Abstract Aging is driven by fundamental mechanisms like oxidative stress, telomere shortening and changes in DNA methylation, which together prepare the ground for age-related diseases. Botanical extracts, rich bioactive phytoconstituents, represent a promising resource developing therapies that target these to promote healthy aging. This study explores geroprotective potential of Monarda didyma L. extract. In vitro analyses revealed extract’s strong antioxidant activity, ability reduce shortening, capacity protect against damage, thereby decreasing cellular senescence improving endothelial function. The randomized, double-blind clinical trial demonstrated daily oral supplementation with extract significantly improved leukocyte length (LTL) stabilized methylation age (DNAmAge) intervention group, while placebo group experienced accelerated epigenetic aging hypermethylation critical genes (ELOVL2 FHL2). also reported enhanced quality life, particularly physical domain, along movement sleep indices detected questionnaire wearable sensors. These compelling findings position as powerful candidate future therapies, impact
Язык: Английский
Процитировано
0
Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 1869 - 1894
Опубликована: Март 1, 2025
Polygala tenuifolia Willd. (PT) is commonly used to address cognitive impairment (CI), while Magnolia officinalis Rehd. et Wils (MO) often prescribed for gastrointestinal issues as well CI. This study seeks explore the impacts and mechanisms behind combined therapy of PT MO (PM) in treating CI, based on concept gut-brain axis. The characteristic components PT, MO, PM were identified using ultra-high performance liquid chromatography-tandem triple quadrupole mass Spectrometry (UPLC-MS/MS). A mouse model was established by D-gal induction, effects CI evaluated through behavioral tests, pathological staining, Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, network pharmacology analyze potential which improves followed validation Western blotting (WB), traditional Chinese medicine (TEM), Immunofluorescence (IF), 16S rRNA. can each alleviate decline neuropathological damage mice varying degrees, reduce expression pro-inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, LPS) serum or hippocampal tissue, increase SOD GSH levels. Network analysis molecular experiments confirmed that upregulates tight junction s (TJs), enhances proteins cAMP pathway, inhibits p-NF-κB-p65 expression. reverses D-gal-induced gut microbiota dysbiosis, increases abundance SCFA-producing bacteria, decreases LPS-producing bacteria. alleviates reducing inflammation oxidative stress, protecting blood-brain barrier (BBB) intestinal barrier, inhibiting NF-κB activating regulating microbiota.
Язык: Английский
Процитировано
0
Brain Research, Год журнала: 2025, Номер unknown, С. 149590 - 149590
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
3 Biotech, Год журнала: 2025, Номер 15(4)
Опубликована: Март 21, 2025
Язык: Английский
Процитировано
0
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0