Balancing tradition and conservation: exploring plant part substitution in traditional medicine DOI

Bhavana Srivastava,

Himanshu Sharma, Ajay Kumar Meena

и другие.

Journal of Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Lipid-lowering effect of industrial hemp (Cannabis sativa L.) powder on Drosophila melanogaster larvae fed a high-sucrose diet DOI

He Dan,

Shanshan Li,

Weihui Xu

и другие.

South African Journal of Botany, Год журнала: 2025, Номер 180, С. 579 - 587

Опубликована: Март 31, 2025

Язык: Английский

Процитировано

0
TCnet: A Novel Strategy to Predict Target Combination of Alzheimer’s Disease via Network-Based Methods DOI

C. X. Yue,

Baiyu Chen, Fei Pan

и другие.

Journal of Chemical Information and Modeling, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder with an unclear pathogenesis; the traditional ″single gene-single target-single drug″ strategy insufficient for effective treatment. This study explores novel multitarget therapy of AD by integrating multiomics data and employing network analysis. Different from conventional single-target methods, TCnet adopts mechanism-driven strategy, utilizing to decompose mechanisms, construct potential target combinations, prioritize optimal combinations using scoring function. not only advances our understanding mechanisms but also facilitates large-scale drug screening. approach was further employed screen active compounds Huang-Lian-Jie-Du-Tang (HLJDT), identifying quercetin as candidate targeting GSK3β ADAM17. Subsequent in vitro experiments confirmed neuroprotective anti-inflammatory effects quercetin. Overall, offers promising predicting provides new insights directions discovery AD.

Язык: Английский

Процитировано

0
Single-nucleus RNA sequencing and network pharmacology reveal the mediation of fisetin on neuroinflammation in Alzheimer's disease DOI
Tingting Cao,

Peiling Liao,

Jia Lu

и другие.

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156724 - 156724

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Integrating network pharmacology and in vivo study to explore the anti-Alzheimer’s potential of Bergenia ligulata and Nelumbo nucifera DOI

Yamini Patel,

Nilay Solanki, Prarambh S. R. Dwivedi

и другие.

3 Biotech, Год журнала: 2025, Номер 15(5)

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

0
Balancing tradition and conservation: exploring plant part substitution in traditional medicine DOI

Bhavana Srivastava,

Himanshu Sharma, Ajay Kumar Meena

и другие.

Journal of Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0