Combination model of neutrophil to high-density lipoprotein ratio and system inflammation response index is more valuable for predicting peripheral arterial disease in type 2 diabetic patients: A cross-sectional study
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 16, 2023
Background
Neutrophil/high-density
lipoprotein
(HDL)
ratio
(NHR),
monocyte/HDL
(MHR),
lymphocyte/HDL
(LHR),
platelet/HDL
(PHR),
systemic
immune-inflammation
index
(SII),
system
inflammation
response
(SIRI),
and
aggregate
of
(AISI)
have
been
recently
investigated
as
novel
inflammatory
markers.
Herein,
the
correlation
was
between
these
biomarkers
peripheral
arterial
disease
(PAD)
in
type
2
diabetes
mellitus
(T2DM)
patients.
Methods
In
this
retrospective
observational
study,
hematological
parameter
data
216
T2DM
patients
without
PAD
(T2DM-WPAD)
218
with
(T2DM-PAD)
at
Fontaine
stages
II,
III
or
IV
stage
had
collected.
Differences
NHR,
MHR,
LHR,
PHR,
SII,
SIRI,
AISI
were
analyzed,
receiver
operating
characteristic
(ROC)
curves
used
to
analyze
diagnostic
potential
parameters.
Results
The
levels
SIRI
T2DM-PAD
significantly
higher
than
T2DM-WPAD
(
P
<
0.001).
They
correlated
severity.
Further,
multifactorial
logistic
regression
analyses
showed
that
might
be
independent
risk
factors
for
areas
under
curve
(AUCs)
0.703,
0.685,
0.606,
0.648,
0.711,
0.670,
respectively.
AUC
NHR
combined
model
0.733.
Conclusion
patients,
they
independently
linked
its
clinical
combination
most
valuable
predicting
–
PAD.
Язык: Английский
Impact of diabetes mellitus on tuberculosis prevention, diagnosis, and treatment from an immunologic perspective
Exploration,
Год журнала:
2024,
Номер
4(5)
Опубликована: Март 5, 2024
Abstract
The
coexistence
of
diabetes
mellitus
(DM)
and
tuberculosis
(TB)
presents
a
significant
global
burden,
with
DM
being
recognized
as
major
risk
factor
for
TB.
This
review
comprehensively
analyzes
the
immunological
aspects
DM‐TB
comorbidity,
shedding
light
on
impact
TB
pathogenesis
immune
responses.
It
reveals
that
high
blood
glucose
levels
in
patients
contribute
to
reduced
innate
cell
count,
compromised
phagocytic
function,
delayed
antigen
presentation.
These
factors
ultimately
impair
clearance
Mycobacterium
(MTB)
delay
adaptive
With
interaction
between
DM,
there
is
an
increase
inflammation
elevated
secretion
pro‐inflammatory
cytokines
by
cells.
exacerbates
inflammatory
response
contributes
poor
treatment
outcomes
Moreover,
explores
effects
prevention,
diagnosis,
treatment.
highlights
how
glycemic
control,
insulin
resistance
(IR),
complications,
genetic
MTB
infection
individuals
DM.
Additionally,
DM‐related
suppression
adversely
affects
sensitivity
traditional
diagnostic
tests
TB,
potentially
resulting
underdiagnosis
intervention.
To
mitigate
burden
patients,
emphasizes
need
further
research
mechanisms
underlying
reactivation
latent
(LTBI).
shows
important
it
find
treat
LTBI
soon
possible
suggests
looking
into
biomarkers
are
specific
make
diagnosis
more
accurate.
Язык: Английский
Complete blood count inflammation derived indexes as predictors of metabolic syndrome in type 2 diabetes mellitus
Technology and Health Care,
Год журнала:
2024,
Номер
32(4), С. 2321 - 2330
Опубликована: Янв. 16, 2024
BACKGROUND:
Metabolic
syndrome
(MetS)
is
a
group
of
comorbidities
related
to
regulating
hyperglycemia
and
acute
cardiovascular
incidents
complications.
With
the
increasing
prevalence
in
individuals
with
type
2
diabetes
mellitus
(T2DM),
MetS
represents
an
public
health
problem
clinical
challenge,
early
diagnosis
necessary
avoid
accelerated
development
diabetic
OBJECTIVE:
To
investigate
role
Complete
Blood
Count-derived
Inflammation
Indexes
(CBCIIs)
predicting
T2DM
individuals.
METHODS:
The
study
was
designed
as
two-year
prospective
included
80
divided
into
non-MetS
groups
based
on
over
two
years.
sera
samples
were
analyzed
for
complete
blood
count
parameters
C-reactive
protein
(CRP).
Based
laboratory
test
results,
13
CBCIIs
calculated
analyzed.
receiver
operating
characteristic
(ROC)
curve
their
corresponding
areas
under
(AUC)
used
determine
prognostic
accuracy.
RESULTS:
There
significant
differences
between
participants
Mets
those
without
concerning
Neutrophil
Platelet
Ratio
(NPR)
values
(p<
0.001),
Lymphocyte
(NLPR)
(PLR)
(LCR)
(CRP/Ly)
Systemic
immune
inflammation
index
(SII)
(<
Aggregate
Index
(AISI)
(p=
0.005).
results
ROC
analysis
have
shown
that
LCR
(AUC
0.907),
CRP/Ly
0.907)
can
serve
excellent
predictors,
but
NPR
0.734),
NLRP
0.755),
PLR
0.823),
SII
0.745),
AISI
0.688)
good
predictors
T2
DM
CONCLUSION:
This
confirms
reliability
novel,
simple,
low
cost
valuable
developing
T2DM.
Язык: Английский
A Novel Inflammatory Indicator for Tuberculosis-Associated Obstructive Pulmonary Disease (TOPD): The Systemic Inflammatory Response Index (SIRI)
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 4219 - 4228
Опубликована: Июль 1, 2024
Background:
The
development
of
chronic
obstructive
pulmonary
disease
(COPD)
following
tuberculosis
(TB)
is
known
as
tuberculosis-associated
(TOPD).
This
study
aimed
to
explore
the
predictive
value
inflammatory
indicators
for
TOPD
in
TB
patients.
Methods:
Data
this
cross-sectional
were
collected
between
January
2014
and
2022
at
Wuhan
Jinyintan
Hospital.
ratio
indicators,
including
Systemic
Inflammatory
Response
Index
(SIRI),
C-reactive
protein-to-lymphocyte
(CLR),
eosinophil
count-to-lymphocyte
count
(ELR),
calculated.
Univariate
multivariate
logistic
regression
analyses
conducted
association
TOPD.
Furthermore,
relationship
was
investigated
using
propensity
score
matching
(PSM)
receiver
operating
characteristic
(ROC)
curve
analysis
performed
evaluate
their
Results:
present
included
a
total
737
patients,
whom
83
participants
(11.26%)
had
Sixty-nine
patients
69
non-TOPD
(NTOPD)
successfully
matched.
multivariable
logistics
analysis,
before
after
PSM,
revealed
that
SIRI
independently
significantly
associated
with
an
increased
risk
area
under
(AUC)
0.702
0.668
respectively.
Additionally,
stratified
into
four
different
groups
based
on
quartiles
further
analysis.
prevalence
showed
increase
higher
values,
both
PSM.
Conclusion:
Levels
when
compared
NTOPD
may
be
simple
useful
index
assessing
TOPD,
values
are
more
likely
high-risk
group
Keywords:
disease,
systemic
response
index,
indicator,
Язык: Английский
The survival analysis of rifampicin/multidrug-resistant tuberculosis patients based on the levels of inflammatory biomarkers: a retrospective cohort study
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Май 1, 2023
The
development
of
tuberculosis
and
inflammatory
status
are
closely
related.
aim
this
study
was
to
investigate
the
prognostic
value
biomarkers
in
patients
with
rifampicin/multidrug-resistant
(RR/MDR-TB).This
recruited
504
RR/MDR-TB
from
Wuhan
Jinyintan
Hospital.
A
total
348
RR/MDR
January
2017
December
2019
were
defined
as
training
set,
rest
validation
set.
divided
into
three-risk
degrees
according
levels
(median,
85th
percentile).
Kaplan-Meier
curve
log-rank
test
used
assess
survival
differences
among
groups.
Cox
proportion
risk
regression
identify
factors
for
mortality.In
cox
analysis
showed
that
high
age
(≥60
years)
[OR
(95%CI):1.053(1.03188-1.077)],
smoking
(95%CI):2.206(1.191-4.085)],
bronchiectasia
(95%CI):2.867(1.548-5.311)]
patients.
In
addition,
lower
rates
observed
CAR
group
(95%CI):1.464(1.275-1.681)],
CPR
group[OR
(95%CI):1.268(1.101-1.459)],
CLR
(95%CI):1.004(1.002-1.005)],
NLR
(95%CI):1.103(1.069-1.139)],
PLR
(95%CI):1.003(1.002-1.004)],
MLR
(95%CI):3.471(2.188-5.508)].Furthermore,
AUCs
age,
smoking,
bronchiectasia,
CAR,
CPR,
CLR,
NLR,
PLR,
predicting
mortality
0.697(95%CI:0.618-0.775),
0.603(95%CI:0.512-0.695),
0.629(95%CI:0.538-0.721),
0.748(95%CI:0.675-0.821,
P<0.05),
0.754(95%CI:0.683-0.824,
0.759(95%CI:0.689-0.828,
0.789(95%CI:0.731-0.846,
0.740(95%CI:0.669-0.812,
0.752(95%CI:0.685-0.819,
respectively.
Importantly,
AUC
combination
six
[0.823
(95%CI:0.769-0.876)]
is
higher
than
any
single
biomarkers.
Additionally,
similar
results
also
obtained
set.Inflammatory
could
predict
Therefore,
more
attention
should
be
paid
level
clinical
practice.
Язык: Английский
Nutritional Indices Predict All Cause Mortality in Patients with Multi-/Rifampicin-Drug Resistant Tuberculosis
Infection and Drug Resistance,
Год журнала:
2024,
Номер
Volume 17, С. 3253 - 3263
Опубликована: Июль 1, 2024
Background:
Multidrug-
and
rifampicin-resistant
tuberculosis
(MDR/RR-TB)
with
high
mortality
remains
a
public
health
crisis
security
threat.
This
study
aimed
to
explore
the
predictive
value
of
nutritional
indices
for
all-cause
(ACM)
in
MDR/RR-TB
patients.
Methods:
We
retrospectively
recruited
patients
between
January
2015
December
2021,
randomly
assigning
them
training
validation
cohorts.
Patients
were
divided
into
risk
groups
(HNRGs)
low
(LNRGs)
based
on
optimal
cut-off
obtained
from
receiver
operating
characteristic
(ROC)
analyses
hemoglobin-albumin-lymphocyte-platelet
(HALP)
score,
prognostic
index
(PNI),
controlling
status
(CONUT)
score.
In
cohort,
Kaplan-Meier
survival
curves
Log
rank
tests
used
compare
overall
(OS)
groups.
Cox
proportion
regression
factors
ACM
MDR/RR-TB.
The
performance
was
assessed
using
area
under
curve
(AUC),
sensitivity
specificity
ROC
analyses.
Results:
A
total
524
patients,
255
cohort
269
included.
Survival
revealed
significantly
lower
OS
HNRGs
compared
LNRGs.
After
adjusting
covariates,
multivariate
analysis
identified
HALP
PNI
CONUT
score
independent
demonstrated
good
AUCs
0.765,
0.783,
0.807,
0.811
PNI,
their
combination,
respectively.
Similar
results
observed
set.
Conclusion:
scores
could
effectively
predict
Hence,
routine
screening
malnutrition
should
be
given
more
attention
clinical
practice
identify
at
higher
provide
support
reduce
mortality.
Keywords:
multidrug-
rifampicin-
resistant
tuberculosis,
all-
cause
mortality,
nutrition
Язык: Английский
Association between serum globulins and diabetes mellitus in American latent tuberculosis infection patients: A cross-sectional study
Medicine,
Год журнала:
2024,
Номер
103(40), С. e39949 - e39949
Опубликована: Окт. 4, 2024
Diabetes
mellitus
(DM)
is
predisposing
to
the
development
of
latent
tuberculosis
infection
(LTBI).
An
understanding
underlying
factors
LTBI–DM
important
for
prevention
and
control.
This
study
aims
evaluate
association
between
LTBI
DM
among
noninstitutionalized
civilian
population
in
United
States,
focusing
on
impact
serum
globulins.
We
performed
a
cross-sectional
design
using
public
data
from
2011
2012
National
Health
Nutrition
Examination
Survey,
participants
diagnosed
with
who
were
aged
20
above.
Weighted
Wilcoxon
rank-sum
weighted
chi-square
tests
used
compare
group
differences.
A
multivariable
logistic
regression
model
was
constructed
assess
globulin
DM,
subgroup
analyses
evaluations
nonlinear
relationships.
Receiver
operating
characteristic
curves
predictive
power
models.
total
694
(512
182
nonDM)
included
our
incidence
22%.
Higher
levels
significantly
associated
an
increased
risk
21%
increase
each
unit
(odds
ratio
=
1.21,
95%
confidence
interval
[1.03,
1.43],
P
<
.001).
The
relationship
linear,
higher
particularly
males
(
.043)
obese
individuals
.019).
area
under
curve
predicting
0.795,
optimal
cutoff
value
2.9.
Elevated
are
LTBI,
highlighting
potential
role
as
biomarker
this
population.
However,
specific
mechanism
needs
be
further
investigated.
Язык: Английский
Risk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: The CRAFT Model
Jinqiang Guo,
Chunli Mei,
Qi Yu
и другие.
Medical Science Monitor,
Год журнала:
2023,
Номер
29
Опубликована: Июнь 8, 2023
BACKGROUND
Anti-melanoma
differentiation-associated
protein
5-positive
dermatomyositis
(MDA5⁺
DM)
is
characterized
by
a
life-threatening
complication
of
rapidly
progressive
interstitial
lung
disease
(RP-ILD).
Early
prediction
RP-ILD
can
enhance
diagnostic
accuracy
and
therapeutic
efficacy.
This
study
was
conducted
to
develop
nomogram
model
for
predicting
in
patients
with
MDA5⁺
DM.
MATERIAL
AND
METHODS
We
retrospectively
analyzed
53
DM,
whom
21
were
diagnosed
between
January
2018
2021.
Univariate
analysis
(t
test,
Mann-Whitney
U
chi-squared
or
Fisher's
exact
test)
receiver
operating
characteristic
(ROC)
used
select
candidate
variables.
Multivariate
logistic
regression
construct
model,
which
subsequently
transformed
into
nomogram.
ROC
analysis,
calibration
curve
decision
performed
evaluate
the
model's
performance.
The
bootstrapping
method
(resampling=500)
internal
validation.
RESULTS
successfully
established
nomogram,
called
CRAFT
predict
DM
patients.
included
4
variables,
namely
C-reactive
protein-to-albumin
ratio,
red
blood
cell
distribution
width-coefficient
variation,
fever
status,
CD3⁺
T
cells.
presented
high
predictive
power
good
performance
analysis.
In
addition,
had
ability
CONCLUSIONS
could
help
Язык: Английский
CRP/Lymphocyte Ratio and CRP/Albumin Ratio for Prognosis of Hyperglycemia in Patients Tuberculosis with Diabetes Mellitus
Jurnal Kesehatan Manarang,
Год журнала:
2024,
Номер
10(3), С. 280 - 280
Опубликована: Дек. 17, 2024
The
issue
is
complicated
by
the
rise
in
Diabetes
Mellitus
(DM)
cases,
a
known
risk
factor
for
pulmonary
TB,
with
15%
of
TB
patients
having
history
DM.
DM
and
chronic
hyperglycemia
impair
immune
function,
leading
to
long-term
inflammation
worsening
prognosis.
Diagnostic
methods
include
blood
culture,
AFB
examination,
chest
X-ray,
genotyping,
but
more
accessible
tests
are
needed.
Inflammatory
markers,
particularly
lymphocytes,
play
crucial
role
prognosis
Lymphopenia
indicates
shift
memory
lymphocytes.
CRP,
an
inflammatory
marker,
inflammation,
hypoalbuminemia
due
kidney
damage
further
complicates
ratios
CRP
lymphocytes
(CLR)
albumin
(CAR)
gaining
attention
better
illustrate
This
cross-sectional
study
analyzed
CLR
CAR
as
prognostic
indicators
30
Jambi
City
from
May
June
2024.
was
tested
at
Prodia
Laboratory,
while
Albumin,
Lymphocytes,
glucose
levels
were
Labkesda
Province.
results
show
Comparison
each
parameter
based
on
treatment
status.
Both
parameters
slightly
higher
average
values
intensive
(<
2
months),
5.55
1.82
CAR,
there
significant
difference
between
follow-up
statuses,
ROC
curve
shows
that
have
indicated
high
sensitivity
low
false
positive
rate
AUC
0,692.
A
relationship
found
p-value
0.024
r-value
0.411,
indicating
moderately
strong
where
increase
CRP-Lymphocyte
ratio
corresponds
than
parameter.
Язык: Английский
Relationship Between Clinical, Laboratory, and Radiological Symptoms with The Incidence of Active Pulmonary Tuberculosis in People with Type 2 Diabetes Mellitus
International Journal Of Scientific Advances,
Год журнала:
2023,
Номер
4(6)
Опубликована: Янв. 1, 2023
Background:
Type
2
diabetes
mellitus
(DM)
is
an
independent
risk
factor
for
TB
that
increases
the
of
morbidity
and
mortality.
Method:
This
research
observational
analytical
study
using
a
cross-sectional
design,
which
was
conducted
at
Prof.
Ngoerah
General
Hospital
Denpasar,
Bali
over
3-year
period
(January
2019-March
2023).
Results:
There
were
106
samples
met
inclusion
criteria
consisting
53
DM-TB
subjects
non-TB
DM
subjects.
The
results
bivariate
analysis
showed
there
significant
relationship
between
cough
(PR=
13.67,
p=
<0.001),
weight
loss
3.18,
night
sweats
2.02,
0.001),
NLR³
4.76
2.53,
MLR³
0.44
2.58,
anemia
2.26,
uncontrolled
HbA1c
1.65,
0.042)
with
incidence
active
pulmonary
in
people
type
DM.
multivariate
variables
consisted
(OR=
91.90,
<
11.32,
24.27,
p
=
0.008),
atypical
lesions
2183.74
0.002),
typical
12273.19,
p=0.033)
affect
scoring
obtained
if
suggestive
major
by
adding
one
or
more
minor
non-suggestive
without
criteria.
Conclusion:
coughing,
sweats,
loss,
increased
NLR,
MLR,
HbA1c,
anemia,
Язык: Английский