International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 6367 - 6377
Опубликована: Ноя. 1, 2023
Purpose:
Molecular
targeted
therapy
is
one
of
the
most
pivotal
strategies
in
treatment
non-small
cell
lung
cancer,
yet
its
curative
effect
severely
compromised
by
poor
aqueous
solubility,
low
bioavailability
and
inadequate
tumor
accumulation
agents.
To
enhance
efficacy
agents,
we
demonstrate
a
novel
self-assemble
amphiphilic
molecule
based
on
erlotinib
as
an
effective
nanodrug
for
anti-cancer
treatment.
Methods:
An
composed
hydrophobic
hydrophilic
biotin
block
was
synthesized
characterized
nuclear
magnetic
resonance
(NMR)
well
high-resolution
mass
spectrometry
(HRMS).
Then,
nanoassemblies
molecules
are
formulated
using
nanoprecipitation
method.
Subsequently,
size,
morphology,
uptake,
anticancer
activity
vivo
distribution
newly
constructed
were
systematically
assessed
some
methods,
including
transmission
electron
microscopy
(TEM),
dynamic
light-scattering
(DLS),
flow
cytometry,
imaging
system
etc.
Results:
We
developed
nanoformulation
erlotinib,
which
possesses
high
drug
loading
45%.
With
features
well-defined
structure
small
obtained
could
be
effectively
accumulated
sites
rapidly
internalized
cancer
cells.
Finally,
erlotinib-based
showed
considerably
better
compared
to
free
both
vitro
vivo.
Moreover,
displayed
great
tolerability.
Conclusion:
Combining
advantageous
nanotechnology
self-assemble,
this
nanomedicine
constitutes
promising
therapeutic
candidate
This
study
also
underlines
potential
use
improving
reducing
toxicity,
become
general
strategy
preparation
nanodrugs
active
Keywords:
molecule,
self-assembling,
self-delivery
system,
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(9), С. 10419 - 10428
Опубликована: Апрель 25, 2024
5-Fluorouracil
(5FU)
and
its
derivatives
have
been
widely
used
for
cancer
treatment;
however
they
fail
to
achieve
selective
chemotherapy.
Herein,
this
work
highlights
a
successful
development
of
pH-sensitive
aliphatic
5-fluorouracil
derivative
prodrug,
which
is
synthesized
via
chemically
linking
5FU
stearyl
alcohol
(SA)
using
ortho
ester
linkage.
It
can
further
self-assemble
into
synergistic
small
molecule
nanodrug
through
noncovalent
interaction
with
doxorubicin
(DOX).
The
displays
precise
structure
high
drug
loading
(more
than
15%
content
(DLC)
87%
efficiency
(DLE)).
SA
linkages
endow
the
lipophilicity
on
tumor
cell
membrane
tumoral
intracellular
pH
response,
respectively.
also
exhibits
slightly
negatively
charged
surface
(−0.513
mV)
at
physiological
(7.4)
large-to-small
size
change
from
176.2
128.9
nm
(5.0).
These
superior
characteristics
nanodrugs
blood
circulation
stability,
accumulation,
improved
cellular
uptake,
efficient
release,
as
well
effect
cells,
thereby
significantly
inhibiting
growth
(smaller
initial
size),
reducing
side
effects,
prolonging
survival
time.
Thus,
such
self-assembled
DOX
has
great
potential
therapy,
greatly
advancing
their
clinical
use.
Crystal Growth & Design,
Год журнала:
2024,
Номер
24(13), С. 5834 - 5864
Опубликована: Июнь 12, 2024
Iron
oxides
are
multifunctional
materials
that
have
been
extensively
explored
for
many
applications,
including
in
novel
biomedical
applications.
However,
boosting
their
ability
purposes
remains
a
significant
challenge.
Many
strategies
proposed
to
increase
the
feasibility
of
iron
such
as
doping
and
defect
engineering,
compositing
decorating,
surface
interface
structure
morphology
development.
This
review
focuses
on
essential
advancements
implementation
The
discussion
starts
with
design
drug
delivery,
heat
contrast
agents,
nanorobots,
disease-sensing
systems.
We
also
discuss
obstacle
applications
continue
by
proposing
plausible
strategy
enhance
provided
perspectives
can
enrich
information
pave
way
finding
biomedical-related
believe
our
could
shed
light
how
bring
close
real
purposes.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 6367 - 6377
Опубликована: Ноя. 1, 2023
Purpose:
Molecular
targeted
therapy
is
one
of
the
most
pivotal
strategies
in
treatment
non-small
cell
lung
cancer,
yet
its
curative
effect
severely
compromised
by
poor
aqueous
solubility,
low
bioavailability
and
inadequate
tumor
accumulation
agents.
To
enhance
efficacy
agents,
we
demonstrate
a
novel
self-assemble
amphiphilic
molecule
based
on
erlotinib
as
an
effective
nanodrug
for
anti-cancer
treatment.
Methods:
An
composed
hydrophobic
hydrophilic
biotin
block
was
synthesized
characterized
nuclear
magnetic
resonance
(NMR)
well
high-resolution
mass
spectrometry
(HRMS).
Then,
nanoassemblies
molecules
are
formulated
using
nanoprecipitation
method.
Subsequently,
size,
morphology,
uptake,
anticancer
activity
vivo
distribution
newly
constructed
were
systematically
assessed
some
methods,
including
transmission
electron
microscopy
(TEM),
dynamic
light-scattering
(DLS),
flow
cytometry,
imaging
system
etc.
Results:
We
developed
nanoformulation
erlotinib,
which
possesses
high
drug
loading
45%.
With
features
well-defined
structure
small
obtained
could
be
effectively
accumulated
sites
rapidly
internalized
cancer
cells.
Finally,
erlotinib-based
showed
considerably
better
compared
to
free
both
vitro
vivo.
Moreover,
displayed
great
tolerability.
Conclusion:
Combining
advantageous
nanotechnology
self-assemble,
this
nanomedicine
constitutes
promising
therapeutic
candidate
This
study
also
underlines
potential
use
improving
reducing
toxicity,
become
general
strategy
preparation
nanodrugs
active
Keywords:
molecule,
self-assembling,
self-delivery
system,
