Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 204 - 215

Опубликована: Май 31, 2024

Язык: Английский

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Biomimetic Single‐Atom Nanozyme for Dual Starvation‐Enhanced Breast Cancer Immunotherapy

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Abstract Cold exposure (CE) therapy is an innovative and cost‐efficient cancer treatment that activates brown adipose tissue to compete for glucose uptake, leading metabolic starvation in tumors. Exploring the combined antitumor mechanisms of CE traditional therapies (such as nanocatalysis) exciting promising. In this study, a platelet membrane biomimetic single‐atom nanozyme (SAEs) nanodrug (PFB) carrying bis‐2‐(5–phenylacetamido‐1, 2, 4‐thiadiazol‐2‐yl) ethyl sulfide (BPTES) developed use therapy. Owing modification, PFB can effectively target Upon entering cells, dual effect induced by BPTES significantly diminish intracellular ATP levels, resulting substantial reduction cellular (glutathione) GSH, which enhance cytotoxic efficacy reactive oxygen species generated SAEs. This strategy not only boosts ROS production tumors, but also strengthens immune responses, particularly increasing memory T‐cell abundance suppressing distant tumor growth metastasis. Compared with SAEs alone, approach offers superior benefits immunotherapy. study achieves combination nanomedicines first time, providing new ideas future nanomedicine modalities.

Язык: Английский

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Near-infrared DNA-AgNCs enzyme-free fluorescence biosensing for microRNA imaging in living cells based on self-replicating catalytic hairpin self-assembly

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 294, С. 139489 - 139489

Опубликована: Янв. 5, 2025

Язык: Английский

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Cold Exposure Therapy Enhances Single-Atom Nanozyme-Mediated Cancer Vaccine Therapy

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Single-atom nanozymes are highly effective in the preparation of tumor vaccines (TV) due to their superior peroxidase (POD) activity and excellent biocompatibility. However, immunosuppressive environment within tumors can diminish efficacy these vaccines. Cold exposure (CE) therapy, a noninvasive straightforward antitumor method, not only suppresses metabolism but also ameliorates milieu. In this study, we developed personalized TV using copper single-atom nanozyme (Cu SAZ) enhanced long-term by introducing CE. We initially synthesized Cu SAZ via high-temperature carbonization, which demonstrated robust POD photothermal characteristics. Upon 808 nm laser irradiation, generated reactive oxygen species (ROS) heat, inducing immunogenic cell death 4T1 breast cancer cells or CT26 colon facilitating production. our vivo prevention treatment model, noted that CE significantly boosted TV. The primary mechanism involves CE's ability lower ratio myeloid-derived suppressor (MDSCs), decrease glucose cells, increase proportions CD8+ T memory cells. Collectively, findings offer promising avenues for designing innovative systems.

Язык: Английский

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Thermosensitive hydrogel loaded with nanozyme and BPTES for enhanced tumor catalytic therapy

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 251, С. 114600 - 114600

Опубликована: Фев. 28, 2025

Язык: Английский

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Biomimetic Cascade Nanozyme Catalytic System for the Treatment of Lymph Node Metastasis in Gastric Cancer

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Abstract Lymphatic metastasis of gastric cancer is a challenging issue in clinical practice. Recently, copper single‐atom nanozymes (SAZ) have gained tremendous attention due to its superior peroxidase (POD) activity that has good nonocatalytic tumor therapy (NCT) capabilities, and photothermal properties. Therefore, using high‐expressing P‐selectin platelet membrane (PM) encapsulate SAZ cisplatin proposed, forming PSC nanoparticles. Due their exquisite nanoscale size the unique structure lymphatic vessels, can highly target cells invasive primary tumors metastatic lymph nodes both express CD44. It noteworthy simultaneously perform chemotherapy generate H₂O₂ under action NADPH oxidases (NOXs) further enhance catalytic increase intracellular reactive oxygen species (ROS) production. Both vitro vivo experiments demonstrated targeting elimination capability PCS system cells. In addition, transcriptomic analysis reveals + NIR induced apoptosis MFC This marks first proposal combining drugs for dual‐targeting metastasis, providing new insights into treatment metastasis.

Язык: Английский

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Platelet Membrane Biomimetic Manganese Carbonate Nanoparticles Promote Breast Cancer Stem Cell Clearance for Sensitized Radiotherapy

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1699 - 1707

Опубликована: Фев. 1, 2024

Introduction: The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy radiotherapy (RT). Efficient elimination potential CSCs is crucial for enhancing effectiveness RT. Methods: In this study, we developed a biomimetic hybrid nano-system (PMC) composed MnCO 3 as inner core and platelet membrane (PM) outer shell. By exploiting specific recognition properties surface proteins, PMC enables precise targeting CSCs. Sonodynamic therapy (SDT) was employed using manganese carbonate nanoparticles (MnCO NPs), which generate abundant reactive oxygen species (ROS) upon ultrasound (US) irradiation, thereby impairing CSC self-renewal capacity eradicating Subsequent RT effectively eliminates common tumor cells. Results: Both in vitro cell experiments vivo animal studies demonstrate that SDT mediated by synergistically enhances to selectively combat while inhibiting growth without noticeable side effects. Discussion: Our findings offer novel insights safety profiles Keywords: clearance, radiosensitization, membrane, sonodynamic therapy,

Язык: Английский

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Ferroptosis-inducing nanocomposite hydrogels: A multimodal platform for enhanced cancer therapeutics

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157451 - 157451

Опубликована: Ноя. 1, 2024

Язык: Английский

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