Drug development & registration,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Introduction.
Cellular
systems
for
targeted
delivery
of
drug
and
biological
molecules
(drug
systems,
DDSs)
are
currently
considered
as
a
promising
solution
to
the
problems
nano-
micro-sized
carriers.
Text.
The
review
briefly
examines
fundamental
applied
issues
in
development
cellular
DDSs,
morphofunctional
diversity
which
theoretically
makes
it
possible
solve
pharmacotherapy
various
diseases.
Sources
presented
summarizing
clinical
protocols
use
are,
however,
limited
antitumor
anti-inflammatory
therapy.
advantages,
well
particular
general
disadvantages
using
certain
cells
(blood
cells,
immunocytes,
stem
cells)
platforms
translation
into
practice
vehicles
drugs
(antibiotics,
cytostatics,
monoclonal
antibodies,
enzymes,
etc.)
loaded
DDSs.
Conclusion.
Despite
obvious
impressive
successes
research
this
area,
difficult
path
lies
ahead
optimizing
processes
controlled
release
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101773 - 101773
Опубликована: Апрель 17, 2025
Bone
and
joint
diseases
are
debilitating
conditions
that
can
result
in
significant
functional
impairment
or
even
permanent
disability.
Multiscale
metal-based
nanocomposites,
which
integrate
hierarchical
structures
ranging
from
the
nanoscale
to
macroscale,
have
emerged
as
a
promising
solution
this
challenge.
These
materials
combine
unique
properties
of
nanoparticles
(MNPs),
such
enzyme-like
activities,
stimuli
responsiveness,
photothermal
conversion,
with
advanced
manufacturing
techniques,
3D
printing
biohybrid
systems.
The
integration
MNPs
within
polymer
ceramic
matrices
offers
degree
control
over
mechanical
strength,
antimicrobial
efficacy,
manner
drug
delivery,
whilst
concomitantly
promoting
processes
osteogenesis
chondrogenesis.
This
review
highlights
breakthroughs
stimulus-responsive
(e.g.,
photo-,
magnetically-,
pH-activated
systems)
for
on-demand
therapy
their
biocomposite
hybrids
containing
cells
extracellular
vesicles
mimic
native
tissue
microenvironment.
applications
these
composites
extensive,
bone
defects,
infections,
tumors,
degenerative
diseases.
emphasizes
enhanced
load-bearing
capacity,
bioactivity,
be
achieved
through
designs.
Notwithstanding
potential
applications,
barriers
progress
persist,
including
challenges
related
long-term
biocompatibility,
regulatory
hurdles,
scalable
manufacturing.
Finally,
we
propose
future
directions,
machine
learning-guided
design
patient-specific
biomanufacturing
accelerate
clinical
translation.
bridge
innovations
macroscale
functionality,
revolutionary
force
field
biomedical
engineering,
providing
personalized
regenerative
solutions
Nanomaterials,
Год журнала:
2024,
Номер
14(7), С. 648 - 648
Опубликована: Апрель 8, 2024
Nanodynamic
therapy
(NDT)
exerts
its
anti-tumor
effect
by
activating
nanosensitizers
to
generate
large
amounts
of
reactive
oxygen
species
(ROS)
in
tumor
cells.
NDT
enhances
tumor-specific
targeting
and
selectivity
leveraging
the
microenvironment
(TME)
mechanisms
that
boost
immune
responses.
It
also
minimizes
damage
surrounding
healthy
tissues
cytotoxicity
cells,
showing
promise
cancer
treatment,
with
significant
potential.
This
review
covers
research
progress
five
major
nanodynamic
therapies:
photodynamic
(PDT),
electrodynamic
(EDT),
sonodynamic
(SDT),
radiodynamic
(RDT),
chemodynamic
(CDT),
emphasizing
role
advanced
nanotechnology
development
for
purposes.
The
mechanisms,
effects,
challenges
faced
these
NDTs
are
discussed,
along
their
respective
solutions
enhancing
efficacy,
such
as
pH
response,
delivery,
combined
immunotherapy.
Finally,
this
briefly
addresses
clinical
translation
NDT.
Experimental & Molecular Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Reproduction
consists
of
sequential
inflammation-like
events,
primarily
within
the
endometrium,
from
ovulation
to
embryo
implantation,
decidualization
and
delivery.
During
reproductive
cycle,
endometrium
repeatedly
undergoes
cyclic
periods
proliferation,
differentiation,
tissue
breakdown
repair
without
scarring.
Owing
their
phagocytic
activity,
macrophages,
key
players
in
innate
immunity,
are
thought
play
crucial
roles
endometrium.
Endometrial
macrophages
actively
participate
various
stages
remodeling,
particularly
during
pregnancy
establishment.
Traditionally
considered
simple
bystanders
that
clear
debris
prevent
autoimmune
responses
homeostasis,
now
recognized
as
main
actors
with
broad
functional
plasticity
allows
them
fine
tune
balance
between
pro-
anti-inflammatory
inflammation,
remodeling
repair.
Homeostatic
is
determined
by
sum
mediators
produced
two
distinctly
polarized
macrophage
subpopulations.
The
biased
polarization
tissue-resident
may
contribute
pathogenesis
diseases,
such
inflammation
cancer.
Thus,
understanding
how
endometrial
homeostasis
for
deciphering
underlying
mechanisms
disorders.
Nanomedicines
using
extracellular
vesicles,
nanoparticles
noncoding
RNAs
have
recently
been
applied
modulate
alleviate
disease
phenotypes.
Despite
these
advances,
functions
under
physiological
pathophysiological
conditions
remain
poorly
understood,
which
complicates
development
targeted
therapies.
Here
we
update
current
homeostatic
function
putative
contribution
dysfunction
disorders
women,
along
innovative
molecular
therapeutics
resolve
this
issue.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9690 - 9690
Опубликована: Сен. 7, 2024
Alzheimer’s
disease
(AD)
still
prevails
and
continues
to
increase
indiscriminately
throughout
the
21st
century,
is
thus
responsible
for
depreciating
quality
of
health
associated
sectors.
AD
a
progressive
neurodegenerative
disorder
marked
by
significant
amassment
beta-amyloid
plaques
neurofibrillary
tangles
near
hippocampus,
leading
consequent
loss
cognitive
abilities.
Conventionally,
amyloid
tau
hypotheses
have
been
established
as
most
prominent
in
providing
detailed
insight
into
pathogenesis
revealing
associative
biomarkers
intricately
involved
progression.
Nanotheranostic
deliberates
rational
thought
toward
designing
efficacious
nanosystems
strategic
endeavors
diagnosis
therapeutic
implications.
The
exceeding
advancements
this
field
enable
scientific
community
envisage
conceptualize
pharmacokinetic
monitoring
drug,
sustained
targeted
drug
delivery
responses,
fabrication
anti-amyloid
therapeutics,
enhanced
accumulation
across
blood–brain
barrier
(BBB),
giving
an
optimistic
approach
towards
personalized
precision
medicine.
Current
methods
idealized
on
design
bioengineering
array
nanoparticulate
systems
offer
higher
affinity
neurocapillary
endothelial
cells
BBB.
They
recently
attracted
intriguing
attention
early
diagnostic
measures
taken
manage
progression
disease.
In
article,
we
tend
furnish
comprehensive
outlook,
mechanism
conventional
pathogenesis,
new
findings.
We
also
summarize
shortcomings
diagnostic,
prognostic,
approaches
undertaken
alleviate
AD,
unique
window
nanotheranostic
without
disregarding
potential
drawbacks,
side
effects,
safety
concerns.
Journal of Medical Virology,
Год журнала:
2025,
Номер
97(3)
Опубликована: Март 1, 2025
ABSTRACT
Kaposi's
sarcoma‐associated
herpesvirus
(KSHV)
has
been
demonstrated
to
trigger
a
variety
of
malignant
neoplasms,
however,
there
are
currently
no
targeted
pharmaceutical
interventions
available.
MicroRNA(miRNA)‐based
antiviral
and
tumor
therapies
frequently
utilized,
yet
the
challenges
cellular
uptake
susceptibility
degradation
underscore
necessity
for
delivery
system
that
can
effectively
combat
KSHV.
Nonetheless,
despite
efficacy
nanocarriers
in
delivering
drugs
into
cells,
they
continue
encounter
penetrating
brain.
In
this
study,
macrophage
inflammation
model
was
developed
enhance
miR‐34a‐5p
loaded
by
folic
acid‐modified
β‐cyclodextrin
grafted
polyethyleneimine
(β‐CD‐PEI‐FA)
nanocomposites,
based
on
FA
folate
receptors
surface
macrophages
cells.
Both
vivo
vitro
safety
evaluations
were
performed,
which
confirmed
exceptional
biocompatibility.
Assays
involving
coculture
induced
nanodrug‐loaded
KSHV‐positive
cells
efficient
through
macrophages.
This
led
inhibition
proliferation
cell
cycle
cocultured
as
well
significant
reduction
expression
KSHV
pathogenic
genes
RTA
v‐GPCR.
Notably,
fluorescence
imaging
organs
revealed
nanocomposites
brain
tissues,
including
tumors.
Furthermore,
immunohistochemistry
analysis
increased
infiltration
both
tumors
tissues
xenograft
mice.
conclusion,
our
study
presents
pioneering
strategy
employing
carriers
β‐CD‐PEI‐FA/miR‐34a‐5p
nanocomplexes
anti‐KSHV
therapy.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 28, 2025
Research
on
the
role
of
macrophages
in
musculoskeletal
(MSK)
diseases
has
significantly
increased
recent
years.
However,
a
thorough
evaluation
developmental
trajectory
this
field,
including
contributions
prominent
authors
and
primary
research
themes,
remains
insufficient.
Furthermore,
identification
emerging
hotspots
requires
more
detailed
exploration.
This
study
collated
articles
reviews
addressing
"macrophages
MSK
diseases"
published
between
2004
2023,
with
all
data
extracted
from
Web
Science
database.
The
collected
were
analyzed
using
variety
bibliometric
visualization
tools,
such
as
VOSviewer,
CiteSpace,
GraphPad
Prism,
R
packages.
Results
indicate
that
China
United
States
are
leading
contributors
domain.
Among
many
academic
institutions
involved,
Shanghai
Jiao
Tong
University
California
stand
out
most
productive.
journal
"Frontiers
Immunology"
had
highest
publication
output
topic.
five
frequently
explored
domains
include
Immunology,
Rheumatology,
Pharmacology
Pharmacy,
Cell
Biology,
Biochemistry
Molecular
Biology.
These
results
offer
comprehensive
overview
current
state
field
provide
meaningful
insights
for
guiding
future
studies.
