Emerging application of nanomedicine-based therapy in acute respiratory distress syndrome

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 237, С. 113869 - 113869

Опубликована: Март 21, 2024

Язык: Английский

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Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Acute lung injury (ALI) is a life-threatening condition characterized by rapidly progressing respiratory distress and hypoxemia. Oxidative stress-induced inflammation in tissue plays crucial role the progression of ALI. Excessive generation reactive oxygen species (ROS) pulmonary microenvironment activates inflammatory signaling pathways, enhancing transcription pro-inflammatory factors ultimately leading to necrosis. Bilirubin (BR), an exceptional endogenous antioxidant, possesses ability counteract elevated levels through direct reactions or inducing antioxidant systems such as Nrf2/HO-1 signaling. However, its limited solubility poses hindrance further applications. Hence, it imperative develop suitable bilirubin-based system for biological utilization. In this study, we developed ROS-sensitive adaptive nanoscavenger (GP@BR) co-assembling bilirubin-conjugated glycol chitosan (GC-BR) polyethylene (PEG-BR), aiming alleviate oxidative stress ALI treatment. The different conjugations endowed bilirubin derivatives with varying sensitivity towards reacting ROS, enabling GP@BR exert antioxidative properties specifically environments on demand. Besides excellent properties, also demonstrated absorb excess cytokines. Moreover, our optimized facilitated transport across mucosal layer epithelial cells. vivo studies confirmed that significantly improved symptoms suppressed fibrosis. This study highlighted potential multiple actions treatment

Язык: Английский

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Human placental mesenchymal stem cells transplantation repairs the alveolar epithelial barrier to alleviate lipopolysaccharides-induced acute lung injury

Biochemical Pharmacology, Год журнала: 2024, Номер 229, С. 116547 - 116547

Опубликована: Сен. 19, 2024

Язык: Английский

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Natural Compounds Regulate Macrophage Polarization and Alleviate Inflammation Against ALI/ARDS

Biomolecules, Год журнала: 2025, Номер 15(2), С. 192 - 192

Опубликована: Янв. 29, 2025

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a pulmonary disease with high mortality associated inflammation. During the development of ALI/ARDS, macrophages usually polarize toward M1 pro-inflammatory macrophages, promoting inflammatory response in ALI/ARDS and aggravating tissue damage. Natural compounds anti-inflammatory activity have achieved excellent results treatment through different regulatory modes, including macrophage polarization. Of note, flavonoid, brevilin A, tetrahydropalmatine play an important role by modulating phenotypic polarization their cytokine expression innate immune cells lung. Flavonoids are kind naturally occurring polyphenol compound, which has antioxidant activities. Studies found that some flavonoids can alleviate inhibiting cytokines macrophages. Among them, 5-methoxyflavone, acacetin, grape seed proanthocyanidins, luteolin also regulate Therefore, in-depth exploration mechanism lay foundation for application alleviating inflammation-related injury. This review focuses on effects natural potential mechanisms ALI/ARDS.

Язык: Английский

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Therapeutic Effects of Nicotinic Acid from Bubali Cornu on H1n1-Induced Acute Lung Injury in Mice by Suppressing Nos2 Expression

Опубликована: Янв. 1, 2025

Язык: Английский

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Cordyceps Sinensis Reduces Inflammation and Protects BEAS-2B Cells From LPS-Induced THP-1 Cell Injury

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 4143 - 4156

Опубликована: Март 1, 2025

Cordyceps sinensis, an entomogenous fungus with unique biological properties, has demonstrated significant anti-inflammatory potential. However, its effects on inflammation regulation need to be further investigated in detail. In this study, we aimed analyze the sinensis extract (CSE) obtained via ethanol extraction and assess regulation. The secretion of pro-inflammatory cytokines (IL-6, TNF-α, IL-8, IL-1β) level MMP9, Nrf2/HO-1 ROS were evaluated. A transwell system THP-1 BEAS-2B cells was used explore inflammatory damage. Gene ontology (GO) Kyoto encyclopedia genes genomes (KEGG) enrichment analyses conducted differentially expressed genes. CSE exhibited no cytotoxicity at concentrations ≤ 1.6 mg/mL. Treatment LPS-induced significantly inhibited cytokines. reduced inflammation-related protein while upregulating signaling pathway. Fluorescence assays using DCF JC-1 confirmed that help mitigate oxidative stress-induced inflammation. treatment protected from Moreover, immune process a shared GO term between LPS-only combined LPS treatment. KEGG analysis showed is capable regulating associated responses. These findings highlight potential as immune-regulating agent functional foods health products.

Язык: Английский

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A literature-based overview on chemistry, pharmacology, molecular docking and nanotechnological advancements of capsaicin including potential impact on pharmacological action of other drugs with mechanistic insight

Food Chemistry Advances, Год журнала: 2025, Номер 7, С. 100988 - 100988

Опубликована: Май 5, 2025

Язык: Английский

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Isoginkgetin inhibits macrophage activation and ferroptosis of lung epithelial cells under lipopolysaccharide-induced immunological stress via HOXA5-dependent inhibition of the TLR4/NF-κΒ signaling pathway

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117413 - 117413

Опубликована: Май 1, 2025

Язык: Английский

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The involvement of Sting in exacerbating acute lung injury in sepsis via the PARP-1/NLRP3 signaling pathway

Pulmonary Pharmacology & Therapeutics, Год журнала: 2024, Номер 86, С. 102303 - 102303

Опубликована: Июнь 5, 2024

Язык: Английский

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Hyperbaric oxygen-induced acute lung injury: A mouse model study on pathogenic characteristics and recovery dynamics

Frontiers in Physiology, Год журнала: 2024, Номер 15

Опубликована: Окт. 18, 2024

Oxygen is an essential substance for the maintenance of human life. It also widely used in clinical and diving medicine. Although oxygen crucial survival, too much can be harmful. Excessive inhalation a short period time lead to injury, lung one main target organs. Acute injury (ALI) induced by hyperbaric (HBO) notably more severe than that caused normobaric oxygen, yet systematic research on such its regression scarce. In this study, two independent experiments were designed. first experiment, mice exposed 2 atmospheres absolute (ATA), ≥95% 2, 4, 6, 8 h. Changes histopathology, inflammation expression chemokines, alveolar-capillary barrier, 8-OHdG detected before after exposure. second these parameters measured at 0 h, 12 24 h following 6 exposure ATA oxygen. Research indicates ALI HBO characterized histologically alveolar expansion, atelectasis, inflammatory cell infiltration, hemorrhage. At ATA, significant changes barrier observed 95% 4 as evidenced increased Evans blue (EB) extravasation ( p = 0.0200). After exposure, tissue pathology scores, levels, chemotactic factors (such Il6, CCL2, CCL3, CXCL5, CXCL10), intercellular adhesion molecule 1 (ICAM1), vascular (VCAM1) significantly elevated. Compared onset was shortened. Additionally, it markers continued increase leaving environment, peaking starting recover indicating peak occurs within post-exposure, with recovery beginning This contradicts common belief alleviated upon removal from high-oxygen environment. However, EB which reflect damage VE-Cadherin (VE-Cad), tight junction protein (ZO-1), ICAM1, VCAM1 remained altered suggests most sensitive slowest recovering part HBO. These findings provide insights into pathogenesis progression offer references identifying corresponding intervention targets.

Язык: Английский

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