Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 275 - 300
Опубликована: Окт. 11, 2024
An
extensive
variety
of
etiologies,
including
trauma
and
chronic
health
issues,
can
result
in
peripheral
nerve
injuries.
These
injuries
provide
significant
hurdles
regarding
clinical
care
the
eventual
restoration
usual
ability.
In
response
to
these
obstacles,
nanoparticles
have
become
a
viable
therapeutic
approach
that
has
potential
accelerate
regeneration.
This
chapter
includes
thorough
examination
categories
synthetic
processes
related
nanoparticles.
Here,
will
illustrate
critical
role
play
advancing
field
regeneration
through
this
comprehensive
investigation.
Biomedical Materials,
Год журнала:
2024,
Номер
19(5), С. 052008 - 052008
Опубликована: Авг. 22, 2024
Abstract
Soft-tissue
injuries
affecting
muscles,
nerves,
vasculature,
tendons,
and
ligaments
often
diminish
the
quality
of
life
due
to
pain,
loss
function,
financial
burdens.
Both
natural
healing
surgical
interventions
can
result
in
scarring,
which
potentially
may
impede
functional
recovery
lead
persistent
pain.
Scar
tissue,
characterized
by
a
highly
disorganized
fibrotic
extracellular
matrix,
serve
as
physical
barrier
regeneration
drug
delivery.
While
approaches
such
drugs,
biomaterials,
cells,
external
stimulation,
other
forces
show
promise
mitigating
scarring
promoting
regenerative
healing,
their
implementation
remains
limited
challenging.
Ultrasound,
laser,
electrical,
magnetic
forms
stimulation
have
been
utilized
promote
soft
tissue
well
neural
regeneration.
After
tissues
experience
increased
proliferation
Schwann
secretion
neurotropic
factors,
production
myelin,
growth
all
aimed
at
supporting
axon
innervation.
Yet,
outcomes
vary
depending
on
pathophysiology
damaged
nerve,
timing
following
injury,
specific
parameters
employed.
Increased
treatment
intensity
duration
noted
hinder
process
inducing
damage.
These
modalities,
either
alone
or
combination
with
nerve
guidance
conduits
scaffolds,
demonstrated
healing.
However,
literature
currently
lacks
detailed
understanding
used
for
applications.
In
this
article,
we
aim
address
gap
summarizing
existing
reports
providing
an
overview
alongside
associated
outcomes.
Advanced technology in neuroscience .,
Год журнала:
2025,
Номер
2(1), С. 47 - 57
Опубликована: Фев. 6, 2025
Autologous
nerve
grafting
has
long
been
considered
the
gold
standard
treatment
for
repairing
peripheral
injury.
However,
it
faces
challenges
such
as
limited
availability
of
donor
nerves
and
complications
at
site.
As
a
result,
there
an
ongoing
shift
toward
use
novel
biomaterials.
Conductive
nanofiber
guidance
conduits
appear
to
be
optimal
solution
due
their
excellent
mechanical
stability,
structure,
electrical
stimulation
properties,
which
can
help
restore
original
neural
microenvironment.
This
review
article
focuses
on
in-depth
investigation
breakthroughs
in
conductive
regeneration.
It
summarizes
various
materials
that
have
used
development
conduits,
including
carbon
nanofibers,
multiwalled
nanotubes,
reduced
graphene
oxide,
nanoparticles,
polymers
polypyrrole,
polyaniline,
polydioxothiophene.
Furthermore,
this
also
addresses
contributions
manufacturing
strategies,
hybrid
electrospinning
surface
coating,
electrical,
mechanical,
biological
properties
conduits.
covers
practical
applications
these
improving
cell
function
facilitating
tissue
repair.
Although
application
prospects
are
promising,
remain
controlling
ensure
biocompatibility.
Future
research
will
focus
addressing
limitations
optimize
therapeutic
technology,
ultimately
providing
better
outcomes
patients
with
Advances in Wound Care,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Peripheral
nerve
injuries,
especially
those
with
complete
transection
of
major
nerves,
create
significant
morbidity
including
debilitating
pain,
loss
protective
haptic
feedback,
and
impaired
volitional
control
musculature.
The
societal
burden
cost
medical
care
for
these
injuries
are
enormous,
estimates
in
the
United
States
alone
excess
$670
million
per
year.
In
clinical
scenarios
a
segmental
gap
where
end-to-end
coaptation
without
tension
is
not
possible,
"bridge"
or
scaffold
must
be
interposed
to
facilitate
communication
between
proximal
distal
stumps
organized
growth
following
Wallerian
degeneration.
A
multitude
constructs
have
been
created
studied
this
regeneration.
Among
three
overall
types
bridge
employed
contemporary
care-conduit/scaffold,
allograft,
autograft-each
has
downsides
ranging
from
limited
successful
ingrowth
donor
site
morbidity.
Despite
tremendous
work
over
last
150
years
biology
technology
treatment
peripheral
injury,
biological
processes
governing
regeneration
remain
incompletely
understood.
Especially
cases
long
gaps,
there
remains
room
improvement.
Ongoing
studies
identified
several
promising
modalities
scaffolds
more
efficient
effective
neuronal
outgrowth
but
still
require
further
investigation.
Here,
we
review
paradigms
interposing
reexamine
physiology,
regulatory
programs
regeneration,
strategic
targets
neurogenic
pathways
that
may
novel
modalities.
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Апрель 25, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid-beta
(Aβ)
plaques
and
tau
tangles,
which
contribute
significantly
to
neuroinflammation,
central
driver
pathogenesis.
The
activation
microglia
astrocytes,
coupled
with
complex
interactions
between
Aβ
pathologies
innate
immune
response,
leads
cascade
inflammatory
events.
This
process
triggers
release
pro-inflammatory
cytokines
chemokines,
exacerbating
neuronal
damage
fostering
cycle
chronic
inflammation
that
accelerates
neurodegeneration.
Key
signaling
pathways,
such
as
nuclear
factor-kappa
B
(NF-κB),
Janus
kinase/signal
transducer
activator
transcription
(JAK/STAT),
mitogen-activated
protein
kinase
(MAPK),
phosphoinositide
3-kinase/protein
(PI3K/Akt),
are
involved
in
regulating
production
these
mediators,
offering
potential
therapeutic
targets
for
AD.
Recently,
extracellular
vesicles
(EVs)
have
emerged
promising
tool
AD
therapy,
due
their
ability
cross
blood-brain
barrier
(BBB)
deliver
agents.
Despite
challenges
standardizing
EV-based
therapies
ensuring
safety,
EVs
offer
novel
approach
modulating
neuroinflammation
promoting
neuroregeneration.
review
aims
highlight
intricate
relationship
emerging
role
therapeutics
advancing
treatment
strategies.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 5949 - 5981
Опубликована: Май 1, 2025
Fungal
keratitis
(FK),
a
major
cause
of
blindness,
remains
challenging
to
treat
due
poor
drug
penetration
and
antifungal
resistance.
Amphotericin-B
(AmB),
water-insoluble
low-permeability,
necessitates
innovative
delivery
systems
improve
its
therapeutic
efficacy.
AmB
was
encapsulated
within
oleosomes
(Ole)
prepared
using
the
ethanol
injection
method,
phosphatidylcholine
(Lipoid
S100)
sodium
oleate,
resulting
in
nanosized
spherical
globules.
The
optimized
Ole
were
characterized,
then
selected
incorporated
into
polyacrylate/PEG/chitosan-based
microneedles
(AmB-Ole/MNs)
ocular
by
creating
transient
microchannels
on
eye
surface.
showed
droplet
size
(175
±
0.78
nm),
polydispersity
index
(0.33
0.04),
zeta
potential
(31
0.43
mV),
high
entrapment
efficiency
(91±0.63%),
improved
stability,
bioavailability,
controlled
release.
AmB-Ole/MNs
system
increases
corneal
contact
time
via
surface,
achieving
sustained
over
72
hours
with
70%
ex
vivo
permeation
80
compared
AmB.
In
vitro
activity
histopathological
examination
that
has
potent
biofilm
disruption
(>90%)
27
mm
32
zones
inhibition
against
Candida
albicans
Aspergillus
niger,
respectively.
Cytotoxicity
test
reduced
toxicity
biocompatibility
rabbit
model,
tolerance
targeting
TLR4/NLRP3
pathways
studies.
as
an
platform
for
fungal
offers
release,
enhanced
permeation,
activity,
toxicity.
promise
FK.
Macromolecular Materials and Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Abstract
In
recent
times,
the
integration
of
nanomaterials
into
3D
biofabricated
structures
has
become
a
transformative
approach
in
advancing
biomedical
field.
Nanomaterials
exhibit
distinctive
properties
such
as
superior
mechanical
strength,
enhanced
biocompatibility,
and
improved
drug
delivery
efficiency,
making
them
well‐suited
for
use.
This
comprehensive
review
explores
synergistic
potential
combining
nanomaterials—such
metallic,
carbon‐based,
ceramic,
polymeric
nanoparticles—with
advanced
biofabrication
techniques,
including
bioprinting,
melt
electrowriting,
electrospinning.
These
integrations
have
demonstrated
significant
promise
diverse
applications,
regeneration
nerve,
bone,
cardiac
tissues,
wound
healing,
cancer
therapy.
Despite
substantial
progress,
several
challenges
hinder
clinical
translation,
difficulties
achieving
precise
nanomaterial
integration,
biocompatibility
toxicity
concerns,
scalability
manufacturing,
regulatory
complexities.
synthesizes
advancements,
evaluates
existing
challenges,
identifies
key
research
directions
to
address
these
obstacles.
It
highlights
significance
interdisciplinary
collaboration
maximizing
nanomaterial‐integrated
promoting
innovative
advancements
science
healthcare.
RSC Advances,
Год журнала:
2024,
Номер
14(50), С. 36945 - 36959
Опубликована: Янв. 1, 2024
This
review
analyzes
nanozyme
classification,
mechanisms,
and
emerging
applications,
shedding
light
on
their
potential
to
revolutionize
dental
antibacterial
treatments
addressing
current
challenges
future
perspectives
in
development.
World Journal of Stem Cells,
Год журнала:
2024,
Номер
16(5), С. 467 - 478
Опубликована: Май 23, 2024
Unlike
central
nervous
system
injuries,
peripheral
nerve
injuries
(PNIs)
are
often
characterized
by
more
or
less
successful
axonal
regeneration.
However,
structural
and
functional
recovery
is
a
senile
process
involving
multifaceted
cellular
molecular
processes.
The
contemporary
treatment
options
limited,
with
surgical
intervention
as
the
gold-standard
method;
however,
each
option
has
its
associated
limitations,
especially
when
injury
severe
large
gap.
Recent
advancements
in
cell-based
therapy
cell-free
approaches
using
stem
cell-derived
soluble
insoluble
components
of
cell
secretome
fast-emerging
therapeutic
to
treating
acute
chronic
PNI.
recent
pilot
study
leap
forward
field,
which
expected
pave
way
for
enormous,
systematic,
well-designed
clinical
trials
assess
efficacy
mesenchymal
exosomes
bio-drug
either
alone
part
combinatorial
approach,
an
attempt
synergize
best
novel
address
complexity
neural
repair
