International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113881 - 113881
Опубликована: Дек. 24, 2024
Язык: Английский
Theranostics, Год журнала: 2024, Номер 14(8), С. 3358 - 3384
Опубликована: Янв. 1, 2024
With the increase in aging population, occurrence of neurological disorders is rising.Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal invasiveness, and capacity for directed differentiation.However, there are some disadvantages, such as poor quality control, safety assessments, ethical logistical issues.Consequently, scientists have started shift their from cells extracellular vesicles similar structures properties.Beyond these parallels, can enhance biocompatibility, facilitate easy traversal barriers, minimize side effects.Furthermore, cell-derived be engineered load drugs modify surfaces treatment outcomes.In this review, we summarize functions native vesicles, subsequently review strategies engineering applications Alzheimer's disease, Parkinson's stroke, discuss challenges solutions associated with clinical translation vesicles.
Язык: Английский
Процитировано
12
International Journal of Biological Sciences, Год журнала: 2025, Номер 21(2), С. 842 - 859
Опубликована: Янв. 1, 2025
Bone marrow mesenchymal stem cells (BMSCs) -derived extracellular vesicles (EVs), especially small EVs (sEVs), were vastly reported to enable multiple restorative effects on ischemic stroke, yet the protective mechanism of blood-brain barrier (BBB) has not been fully illustrated.In present study, we investigated therapeutic and BMSCs-derived sEVs BBB injury after stroke.In-vivo, administering transient middle cerebral artery occlusion (tMCAo) mice mitigated brain infarct volume, permeability neural apoptosis, improved blood flow perfusion neurological function.Simultaneously, vascular endothelial overexpressed Caveolin-1 (Cav-1) together with its strong co-localization autophagosome protein LC3B suppressed, ZO-1 Occludin expressions enhanced, whose results consistent those oxygen-glucose-deprivation/reperfusion (OGD/R)-insulted (BECs) in vitro.Furthermore, by employing Cav-1 siRNA pcDNA3.1 transfection, Co-immunoprecipitation, cycloheximide assay, molecular docking, it proved that was an essential upstream autophagy activation, contributing tight-junction proteins delegation via autophagy-lysosomal pathway.Altogether, our study demonstrates novel Cav-1-dependent autophagic disruption integrity BMSC-sEVs treatment can reverse such hazard cascades.
Язык: Английский
Процитировано
1
Translational Stroke Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
1
Archives of Pharmacal Research, Год журнала: 2025, Номер unknown
Опубликована: Май 8, 2025
Abstract Angiogenesis, the process of new blood vessel formation, is a fundamental physiological implicated in several pathological disorders. The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are crucial for angiogenesis vasculogenesis. Among them, tyrosine kinase receptor VEGFR-2 primarily expressed cells (ECs). These regulate various responses, including differentiation, cell proliferation, migration, survival, by binding to VEGF mitogens. Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) key regulator this process, making it prime target therapeutic intervention. Several drugs targeting have been approved currently utilized halt axis VEGF-VEGFR. This review will focus on recent developments molecular structure function VEGFR-2, mechanism activation, its downstream signaling pathway. It also discuss therapies experimental inhibit resistance mechanism.
Язык: Английский
Процитировано
1
Neural Regeneration Research, Год журнала: 2024, Номер 20(8), С. 2181 - 2198
Опубликована: Июль 29, 2024
Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for drug delivery, exhibit excellent biocompatibility in vivo have significant advantages the management ischemic stroke. However, uncertain distribution rapid clearance extracellular vesicles impede their delivery efficiency. By utilizing membrane decoration or by encapsulating therapeutic cargo within efficacy may be greatly improved. Furthermore, previous studies indicated that microvesicles, subset large-sized can transport mitochondria to neighboring cells, thereby aiding restoration mitochondrial function post-ischemic Small also demonstrated capability transfer components, such proteins deoxyribonucleic acid, sub-components, vesicle–based therapy. In this review, we undertake comparative analysis isolation techniques employed present an overview current dominant vesicle modification methodologies. Given complex facets treating stroke, delineate various approaches which are suited different treatment process. Moreover, given burgeoning interest delved into feasibility existing research findings transportation fractions intact through small microvesicles offer fresh perspective
Язык: Английский
Процитировано
3
Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Фев. 7, 2025
Ischemic stroke is a leading cause of mortality and long-term disability globally. One its aspects the breakdown blood-brain barrier (BBB). The disruption BBB's integrity during exacerbates neurological damage hampers therapeutic intervention. Recent advances in regenerative medicine suggest that mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs) show promise for restoring BBB integrity. This review explores potential MSC-derived EVs mediating neuroprotective reparative effects on after ischemic stroke. We highlight molecular cargo EVs, including miRNAs, their role enhancing angiogenesis, promoting neural repair, mitigating apoptosis. Furthermore, we discuss challenges associated with clinical translation EV therapies possibilities further EVs' innate protective qualities. Our findings underscore need research to optimize establish efficacy safety settings.
Язык: Английский
Процитировано
0
Materials & Design, Год журнала: 2025, Номер unknown, С. 113832 - 113832
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114764 - 114764
Опубликована: Май 8, 2025
Язык: Английский
Процитировано
0
Food Reviews International, Год журнала: 2024, Номер unknown, С. 1 - 27
Опубликована: Окт. 13, 2024
After cerebral ischemia, the brain encounters noxious stimuli that result in a dysfunctional balance between production and elimination of reactive oxygen species, which turn cause damage to cellular components. Oxidative stress may activate inflammatory response, promoting apoptosis, autophagy, etc. Flavonoids are present wide range foods have antioxidant, anti-inflammatory, antimutagenic anticancer properties. Dietary flavonoid intake beneficial effects against ischemic stroke. flavonoids can significantly reduce risk stroke improve its prognosis by directly scavenging free radicals, regulating redox balance, modulating signaling pathways gene expression counteract caused oxidative after Therefore, this review summarizes effect dietary on
Язык: Английский
Процитировано
0