Extracellular vesicles of ADSCs inhibit ischemic stroke-induced pyroptosis through Gbp3 regulation: A role for the NLRP3/GSDMD signaling pathway DOI
Jia Wang, Hao Tang, Jianan Tian

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113881 - 113881

Опубликована: Дек. 24, 2024

Язык: Английский

Stem cell-derived extracellular vesicles in the therapeutic intervention of Alzheimer's Disease, Parkinson's Disease, and stroke DOI Creative Commons

W. Zhou,

Xudong Wang,

Yumeng Dong

и другие.

Theranostics, Год журнала: 2024, Номер 14(8), С. 3358 - 3384

Опубликована: Янв. 1, 2024

With the increase in aging population, occurrence of neurological disorders is rising.Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal invasiveness, and capacity for directed differentiation.However, there are some disadvantages, such as poor quality control, safety assessments, ethical logistical issues.Consequently, scientists have started shift their from cells extracellular vesicles similar structures properties.Beyond these parallels, can enhance biocompatibility, facilitate easy traversal barriers, minimize side effects.Furthermore, cell-derived be engineered load drugs modify surfaces treatment outcomes.In this review, we summarize functions native vesicles, subsequently review strategies engineering applications Alzheimer's disease, Parkinson's stroke, discuss challenges solutions associated with clinical translation vesicles.

Язык: Английский

Процитировано

12

BMSCs-derived small extracellular vesicles antagonize cerebral endothelial Caveolin-1 driven autophagic degradation of tight-junction proteins to protect blood-brain barrier post-stroke DOI Creative Commons
Yiyang Li,

Xingping Quan,

Jinxia Hu

и другие.

International Journal of Biological Sciences, Год журнала: 2025, Номер 21(2), С. 842 - 859

Опубликована: Янв. 1, 2025

Bone marrow mesenchymal stem cells (BMSCs) -derived extracellular vesicles (EVs), especially small EVs (sEVs), were vastly reported to enable multiple restorative effects on ischemic stroke, yet the protective mechanism of blood-brain barrier (BBB) has not been fully illustrated.In present study, we investigated therapeutic and BMSCs-derived sEVs BBB injury after stroke.In-vivo, administering transient middle cerebral artery occlusion (tMCAo) mice mitigated brain infarct volume, permeability neural apoptosis, improved blood flow perfusion neurological function.Simultaneously, vascular endothelial overexpressed Caveolin-1 (Cav-1) together with its strong co-localization autophagosome protein LC3B suppressed, ZO-1 Occludin expressions enhanced, whose results consistent those oxygen-glucose-deprivation/reperfusion (OGD/R)-insulted (BECs) in vitro.Furthermore, by employing Cav-1 siRNA pcDNA3.1 transfection, Co-immunoprecipitation, cycloheximide assay, molecular docking, it proved that was an essential upstream autophagy activation, contributing tight-junction proteins delegation via autophagy-lysosomal pathway.Altogether, our study demonstrates novel Cav-1-dependent autophagic disruption integrity BMSC-sEVs treatment can reverse such hazard cascades.

Язык: Английский

Процитировано

1

Roles and Potential Mechanisms of Endothelial Cell-Derived Extracellular Vesicles in Ischemic Stroke DOI
Xinyuan Yu, Yiwei Huang,

Changxin Li

и другие.

Translational Stroke Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

1

Targeting vascular endothelial growth receptor-2 (VEGFR-2): structural biology, functional insights, and therapeutic resistance DOI Creative Commons
Fahad Hassan Shah,

Yoon Seok Nam,

Jun Young Bang

и другие.

Archives of Pharmacal Research, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Abstract Angiogenesis, the process of new blood vessel formation, is a fundamental physiological implicated in several pathological disorders. The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are crucial for angiogenesis vasculogenesis. Among them, tyrosine kinase receptor VEGFR-2 primarily expressed cells (ECs). These regulate various responses, including differentiation, cell proliferation, migration, survival, by binding to VEGF mitogens. Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) key regulator this process, making it prime target therapeutic intervention. Several drugs targeting have been approved currently utilized halt axis VEGF-VEGFR. This review will focus on recent developments molecular structure function VEGFR-2, mechanism activation, its downstream signaling pathway. It also discuss therapies experimental inhibit resistance mechanism.

Язык: Английский

Процитировано

1

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery DOI Creative Commons
Jiali Chen, Yiyang Li,

Xingping Quan

и другие.

Neural Regeneration Research, Год журнала: 2024, Номер 20(8), С. 2181 - 2198

Опубликована: Июль 29, 2024

Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for drug delivery, exhibit excellent biocompatibility in vivo have significant advantages the management ischemic stroke. However, uncertain distribution rapid clearance extracellular vesicles impede their delivery efficiency. By utilizing membrane decoration or by encapsulating therapeutic cargo within efficacy may be greatly improved. Furthermore, previous studies indicated that microvesicles, subset large-sized can transport mitochondria to neighboring cells, thereby aiding restoration mitochondrial function post-ischemic Small also demonstrated capability transfer components, such proteins deoxyribonucleic acid, sub-components, vesicle–based therapy. In this review, we undertake comparative analysis isolation techniques employed present an overview current dominant vesicle modification methodologies. Given complex facets treating stroke, delineate various approaches which are suited different treatment process. Moreover, given burgeoning interest delved into feasibility existing research findings transportation fractions intact through small microvesicles offer fresh perspective

Язык: Английский

Процитировано

3

miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery DOI Creative Commons

Vojtech Sprincl,

Nataliya Romanyuk

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 7, 2025

Ischemic stroke is a leading cause of mortality and long-term disability globally. One its aspects the breakdown blood-brain barrier (BBB). The disruption BBB's integrity during exacerbates neurological damage hampers therapeutic intervention. Recent advances in regenerative medicine suggest that mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs) show promise for restoring BBB integrity. This review explores potential MSC-derived EVs mediating neuroprotective reparative effects on after ischemic stroke. We highlight molecular cargo EVs, including miRNAs, their role enhancing angiogenesis, promoting neural repair, mitigating apoptosis. Furthermore, we discuss challenges associated with clinical translation EV therapies possibilities further EVs' innate protective qualities. Our findings underscore need research to optimize establish efficacy safety settings.

Язык: Английский

Процитировано

0

Intravitreal injection of TA-III with sustained release to simultaneously impart anti-inflammatory, antioxidative, and vascular remodeling activities in diabetic retinopathy DOI Creative Commons
Jie Zhang, Yu Liu, Yu Gong

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113832 - 113832

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Preserving Blood–Brain Barrier Integrity in Ischemic Stroke: a Review on MSCs-sEVs Content and Potential Molecular Targets DOI

David Arturo Lozano-López,

Luis Daniel Hernández‐Ortega, Lorenza González‐Mariscal

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Язык: Английский

Процитировано

0

Andrographolide attenuates PM2.5-induced blood–brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways DOI
Kai Kang, Yannan Zhang, Geng Yang

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114764 - 114764

Опубликована: Май 8, 2025

Язык: Английский

Процитировано

0

Reducing Oxidative Stress to Improve Prognosis in Ischemic Stroke: Possible Application of Dietary Flavonoids DOI

Yong-Shi Wu,

Tao Ding, Zhu Li

и другие.

Food Reviews International, Год журнала: 2024, Номер unknown, С. 1 - 27

Опубликована: Окт. 13, 2024

After cerebral ischemia, the brain encounters noxious stimuli that result in a dysfunctional balance between production and elimination of reactive oxygen species, which turn cause damage to cellular components. Oxidative stress may activate inflammatory response, promoting apoptosis, autophagy, etc. Flavonoids are present wide range foods have antioxidant, anti-inflammatory, antimutagenic anticancer properties. Dietary flavonoid intake beneficial effects against ischemic stroke. flavonoids can significantly reduce risk stroke improve its prognosis by directly scavenging free radicals, regulating redox balance, modulating signaling pathways gene expression counteract caused oxidative after Therefore, this review summarizes effect dietary on

Язык: Английский

Процитировано

0