Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 136 - 136

Опубликована: Янв. 19, 2025

Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, challenges NS-based drug delivery, particularly oral, ocular, transdermal, pulmonary, parenteral routes. The conversion oral NS into powders, pellets, granules, tablets, capsules, incorporation film dosage forms to address stability concerns is thoroughly reviewed. article summarizes key stabilizers, polymers, surfactants, excipients used formulations, along ongoing clinical trials patents. Furthermore, comprehensive analysis various methods preparation provided. also explores vitro vivo characterization techniques, as well scale-down technologies bottom-up preparation. Selected examples commercial products discussed. Rapid advances field could resolve issues related permeability-limited absorption hepatic first-pass metabolism, offering promise based on proteins peptides. evolution novel stabilizers essential overcome current limitations stability, bioavailability, targeting ability, safety profile, which ultimately accelerates application commercialization.

Язык: Английский

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Cannabidiol - a friend or a foe?

European Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 107036 - 107036

Опубликована: Фев. 1, 2025

Cannabidiol (CBD), one of the main actives from Cannabis sativa has been perpetually explored lately for its therapeutic effects. Its attributes, such as anti-inflammatory and antioxidant effects, snowball into pain management, epilepsy seizure alleviation, anxiety relief, well numerous other implications through entire metabolism. However, conventional administration routes challenge potential, with reported poor water solubility, hepatic degradation, gastric instability erratic bioavailability observed in oral administration. As a result, transdermal delivery systems have emerged promising alternative to or inhaled routes, offering improved targeted The medical use CBD throughout Europe, UK, USA Australia is extensive usually represented by pharmaceutical preparations recommended after treatment routs fail. non-medical limited each country's own legislation, wider range products being available, but irregular regulatory landscape coupled growing market cannabinoid-infused products, emphasizes need standardized formulations further clinical research. present work critically examines cannabidiol, explores skin's potential route strategies involved using it systemic targeting. We highlighted key challenges provided insights CBD`s variable based on different methods, thus compiling literature-based absorption, distribution, metabolism, excretion (ADME) study. also explore role endocannabinoid system, function various conditions, effects associated CBD, particularly light varying legislation across countries. While breadth benefits compelling, essential emphasize ongoing nature research individual responses can vary significantly.

Язык: Английский

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Dissolving microneedles: drug delivery and disease treatment

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114571 - 114571

Опубликована: Фев. 1, 2025

Язык: Английский

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Design and Bottom-up Production of an Aerosolizable Cannabidiol Nanosuspension

Molecular Pharmaceutics, Год журнала: 2024, Номер 22(1), С. 498 - 508

Опубликована: Дек. 11, 2024

Cannabidiol (CBD), a small nonpsychoactive molecule derived from

Язык: Английский

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