Improved antibacterial activity of a sustained-release biocompatible nanofilm for treating Pseudomonas aeruginosa wound infection in vitro and in vivo DOI Creative Commons

Feifei Lu,

Guoxiu Lu, Zhiguo Wang

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 9, 2025

The primary goal of this research was to design a useful and biocompatible nanofilm system (CNF) encapsulating chlorhexidine acetate (CHX) for wounds that is endowed with antibacterial anti-inflammatory activities promotes wound healing. developed on the basis successful preparation its nanoemulsion PVA-CS film then important properties system, including morphological physicochemical characteristics, stability safety, antimicrobial efficacy against P. aeruginosa also evaluated in vitro vivo. effect, healing effect inflammatory factor change vivo were evaluated. These results revealed good particle size (59.27 nm) stable zeta potential (-15.2 mV) are suitable applications. Additionally, it stable, exhibited long-term (24 months) sustained release simulated fluid. Results showed does not induce dose-related toxic effects displays better occurs more quickly, two times greater than CHX vitro. This safe enhances activity 14 days, modulates immune response, accelerates skin insights into multifunctional designs improved suggest promising clinical

Язык: Английский

Surfactant Mediated Dispersion and stabilization of nano-emulsion droplets enhance antimicrobial activity against multidrug resistant bacteria DOI
Pallavi Shukla,

Priya Ranjan Prasad Verma,

Vinita Tiwari

и другие.

Journal of Molecular Liquids, Год журнала: 2025, Номер 426, С. 127300 - 127300

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Improved antibacterial activity of a sustained-release biocompatible nanofilm for treating Pseudomonas aeruginosa wound infection in vitro and in vivo DOI Creative Commons

Feifei Lu,

Guoxiu Lu, Zhiguo Wang

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 9, 2025

The primary goal of this research was to design a useful and biocompatible nanofilm system (CNF) encapsulating chlorhexidine acetate (CHX) for wounds that is endowed with antibacterial anti-inflammatory activities promotes wound healing. developed on the basis successful preparation its nanoemulsion PVA-CS film then important properties system, including morphological physicochemical characteristics, stability safety, antimicrobial efficacy against P. aeruginosa also evaluated in vitro vivo. effect, healing effect inflammatory factor change vivo were evaluated. These results revealed good particle size (59.27 nm) stable zeta potential (-15.2 mV) are suitable applications. Additionally, it stable, exhibited long-term (24 months) sustained release simulated fluid. Results showed does not induce dose-related toxic effects displays better occurs more quickly, two times greater than CHX vitro. This safe enhances activity 14 days, modulates immune response, accelerates skin insights into multifunctional designs improved suggest promising clinical

Язык: Английский

Процитировано

0