Cancer Pathogenesis and Therapy, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Авг. 21, 2024
Circular RNAs (circRNAs) are unique noncoding that have a closed and stable loop structure generated through backsplicing. Due to their conservation, stability tissue specificity, circRNAs can potentially be used as diagnostic indicators therapeutic targets for certain tumors. Many studies shown act microRNA (miRNA) sponges, engage in interactions with proteins translation templates regulate gene expression signal transduction, thereby participating the occurrence development of variety malignant Immunotherapy has revolutionized treatment cancer. Early researches indicated involved regulating tumor immune microenvironment antitumor immunity. CircRNAs may potential important increasing sensitivity immunotherapy expanding population patients who benefit from cancer immunotherapy. However, few investigated correlation between In this review, we summarize current on regulation different mechanisms value efficacy goal providing new
Язык: Английский
Процитировано
9
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 5, 2024
Abstract PIWI-interacting RNAs (piRNAs) have received a lot of attention for their functions in cancer research. This class short non-coding (ncRNA) has roles genomic stability, chromatin remodeling, messenger RNA (mRNA) integrity, and genome structure. We summarized the mechanisms underlying biogenesis regulatory molecular piRNAs. Among all piRNAs studied cancer, this review offers comprehensive analysis emerging piR-823 various types including colorectal, gastric, liver, breast, renal cancers, as well multiple myeloma. emerged crucial modulator hallmarks through regulating pathways. In current review, we analyzed several databases conducted an extensive literature search to explore influence carcinogenesis addition describing potential application prognostic diagnostic markers therapeutic toward ncRNA precision.
Язык: Английский
Процитировано
8
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104612 - 104612
Опубликована: Янв. 1, 2025
Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, tissue-specific expression. These non-coding function through mechanisms such miRNA sponging, interactions with RNA-binding proteins (RBPs), modulating transcription splicing. Advances RNA sequencing bioinformatics tools enabled the identification functional annotation of across different types. Clinically, demonstrate specificity sensitivity samples, offering potential diagnostic prognostic biomarkers. Additionally, therapeutic strategies involving circRNA mimics, inhibitors, delivery systems are under investigation. However, precise remain unclear, more clinical evidence is needed regarding roles hallmarks. Understanding will pave way for novel approaches, potentially improving patient outcomes.
Язык: Английский
Процитировано
0
Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116789 - 116789
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(4), С. 535 - 535
Опубликована: Апрель 5, 2025
Pharmacogenomics is revolutionizing precision medicine by enabling tailored therapeutic strategies based on an individual genetic and molecular profile. Circular RNAs (circRNAs), a distinct subclass of endogenous non-coding RNAs, have recently emerged as key regulators drug resistance, tumor progression, responses. Their covalently closed circular structure provides exceptional stability resistance to exonuclease degradation, positioning them reliable biomarkers novel targets in cancer management. This review comprehensive analysis the interplay between circRNAs pharmacogenomics, focusing their role modulating metabolism, efficacy, toxicity profiles. We examine how circRNA-mediated regulatory networks influence chemotherapy alter targeted therapy responses, impact immunotherapy outcomes. Additionally, we discuss emerging experimental tools bioinformatics techniques for studying circRNAs, including multi-omics integration, machine learning-driven biomarker discovery, high-throughput sequencing technologies. Beyond diagnostic potential, are being actively explored agents delivery vehicles. Recent advancements circRNA-based vaccines, engineered CAR-T cells, synthetic circRNA therapeutics highlight transformative potential oncology. Furthermore, address challenges standardization, reproducibility, clinical translation, emphasizing need rigorous validation frameworks facilitate integration into practice. By incorporating profiling pharmacogenomic strategies, this underscores paradigm shift toward highly personalized therapies. hold immense overcome enhance treatment optimize patient outcomes, marking significant advancement
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Язык: Английский
Процитировано
0
Cancer Pathogenesis and Therapy, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
2