Molecules,
Год журнала:
2024,
Номер
29(22), С. 5291 - 5291
Опубликована: Ноя. 8, 2024
This
study
reports
the
successful
synthesis
of
core-shell
microparticles
utilizing
coaxial
electrospray
techniques,
with
zeolitic
imidazolate
framework-8
(ZIF-8)
encapsulating
rhodamine
B
(RhB)
in
core
and
a
phase
change
material
(PCM)
shell
composed
eutectic
mixture
lauric
acid
(LA)
stearic
(SA).
ZIF-8
is
well-recognized
for
its
pH-responsive
degradation
biocompatibility,
making
it
an
ideal
candidate
targeted
drug
delivery.
The
LA-SA
PCM
mixture,
melting
point
near
physiological
temperature
(39
°C),
enables
temperature-triggered
release,
enhancing
therapeutic
precision.
structural
properties
were
extensively
characterized
through
scanning
electron
microscopy
(SEM),
X-ray
diffraction
(XRD),
Fourier
transform
infrared
spectroscopy
(FTIR),
differential
calorimetry
(DSC),
thermogravimetric
analysis
(TGA).
Drug
release
studies
revealed
dual-stimuli
response,
where
RhB
was
significantly
influenced
by
both
pH.
Under
mildly
acidic
conditions
(pH
4.0)
at
40
°C,
rapid
complete
observed
within
120
h,
while
37
rate
notably
slower.
Specifically,
°C
79%
higher
than
confirming
sensitivity
system.
Moreover,
pH
(7.4),
minimal
occurred,
demonstrating
system's
potential
minimizing
premature
under
neutral
conditions.
approach
holds
promise
improving
outcomes
cancer
treatment
enabling
precise
control
over
response
to
localized
hyperthermia,
reducing
off-target
effects
patient
compliance.
Antibiotic
resistance
is
a
growing
global
threat
due
to
antibiotic
overuse
and
limited
treatment
options.
Multidrug-resistant
bacteria,
like
Staphylococcus
aureus
Escherichia
coli,
increase
infection
complexity
mortality.
This
study
explores
nanocomposite
films
of
ZIF-8
nanoparticles
Doxycycline
(Dox)
enhance
antibacterial
efficacy.
In
this
study,
composed
chitosan
(CS)
polyethylene
glycol
(PEG),
incorporating
zeolitic
imidazolate
framework-8
(ZIF-8)
DOX,
were
developed.
These
characterized
by
their
morphological,
mechanical,
antibacterial,
drug-release
properties.
Antibacterial
efficacy
was
evaluated
using
disk
diffusion,
broth
microdilution,
checkerboard
assay
methods
determine
MICs
potential
synergistic
effects.
The
demonstrated
flexibility,
semi-transparency,
yellowish-brown
hue,
with
containing
being
thicker
(79
±
0.2
μm)
than
those
without
(54
0.5
μm).
tensile
strength
enhanced
the
incorporation
ZIF-8,
peaking
at
53.12
MPa
for
CS-PEG-G-10%
DOX-4%
film.
XRD
analysis
confirmed
crystallinity
distinct
peaks
observed
each
material.
drug
release
studies
revealed
an
initial
burst
followed
sustained
release,
higher
rates
in
acidic
environments
compared
neutral
alkaline
media.
film
significantly
activity,
achieving
lowest
MIC
values,
particularly
against
S.
(22.5
mm
inhibition
zone)
E.
coli
(14
zone).
Additionally,
notable
effect
between
DOX
FICI
values
below
0.5.
exhibits
optimal
properties,
positioning
it
as
strong
candidate
developing
effective
treatments
multidrug-resistant
pathogens.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
functionalization
strategies
of
ZIF-8
and
challenges
future
developments
in
ZIF-8-based
platforms
for
drug
delivery
cancer
therapy.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 3445 - 3470
Опубликована: Март 1, 2025
Advances
in
nanotechnology
have
opened
new
avenues
for
precision
therapy,
personalized
medicine,
and
multifunctional
theranostics
atherosclerosis
(AS).
This
review
provides
a
comprehensive
overview
of
the
role
nanoparticles
(NPs)
medicine
AS,
discussing
their
applications,
challenges,
future
prospects.
The
first
analyzes
current
treatment
landscape
AS
outlines
potential
biological
targets
therapy.
Various
nanocarriers,
including
organic,
inorganic,
hybrid
systems,
are
evaluated
therapeutic
potential,
with
focus
on
targeted
drug
delivery,
anti-inflammatory
vascular
repair,
plaque
stabilization,
lipid
clearance.
Additionally,
explores
NP
preparation
methods,
emphasizing
strategies
to
enhance
loading,
stability,
controlled
release.
Finally,
translational
challenges
NP-based
therapies,
biocompatibility,
large-scale
production,
regulatory
hurdles,
clinical
implementation,
critically
analyzed.
Future
directions
highlight
importance
interdisciplinary
collaboration
technological
innovation
advancing
nanoparticle-based
AS.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 4551 - 4569
Опубликована: Апрель 1, 2025
Fungal
keratitis
is
a
severe
vision-threatening
corneal
infection
with
prognosis
influenced
by
fungal
virulence
and
the
host's
immune
defense
mechanisms.
However,
there
still
lack
of
effective
drugs
that
attenuate
while
relieving
inflammatory
response
caused
keratitis.
Finding
an
treatment
to
solve
these
problems
particularly
important.
We
synthesized
Zeolitic
imidazolate
framework-90
(ZIF-90)
water-based
synthesis
method
characterized
it.
In
vitro
experiments
included
mycelium
electron
microscopy,
Cell
Counting
Kit-8
(CCK-8),
Enzyme-linked
immunosorbent
assay
(ELISA).
These
trials
verified
disruptive
effects
ZIF-90
on
morphology,
cell
membrane,
wall,
biofilm
formation
Aspergillus
fumigatus
(A.
fumigatus).
also
demonstrated
impact
proinflammatory
cytokines
tumor
necrosis
factor-α
(TNF-α)
interleukin-6
(IL-6).
Moreover,
effect
mitochondrial
reactive
oxygen
species
(mtROS)
cells
fungi
was
MitoSOX
Red
Mitochondrial
Superoxide
Indicator
(MitoSOX).
vivo,
toxicity
test,
establishment
mycotic
mouse
model,
immunofluorescence
staining
were
used
evaluate
efficacy
in
procedure
addition,
investigate
whether
metal-ligand
zinc
organic
ligand
imidazole
acted
as
essential
factors
ZIF-90,
we
investigated
antimicrobial
anti-inflammatory
ZIF-8,
ZIF-67
Metal-Organic
Frameworks-74
(Zn)
(MOF-74
(Zn))
Minimum
Inhibitory
Concentration
(MIC)
ELISA
experiments.
has
therapeutic
keratitis,
which
could
break
protective
organelles
A.
fumigatus,
such
wall.
can
be
targeted
increase
amount
mtROS
promote
apoptosis
macrophages.
The
results
both
ions
possessed
effects.
exhibited
better
antifungal
properties
than
ZIF-67,
MOF-74
(Zn).
