Emerging role of exosomes in cancer therapy: progress and challenges
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Язык: Английский
Exosome Source Matters: A Comprehensive Review from the Perspective of Diverse Cellular Origins
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 147 - 147
Опубликована: Янв. 22, 2025
Exosomes
have
emerged
as
promising
therapeutic
agents
in
regenerative
medicine.
This
review
introduces
a
novel
cell
type-oriented
perspective
to
systematically
analyze
exosomal
properties
therapies.
To
our
knowledge,
this
is
the
first
comprehensively
compare
exosomes
based
on
cellular
source
type,
offering
unprecedented
insights
into
selecting
optimal
exosome
producers
for
targeted
applications.
Factors
beyond
origin
influencing
efficacy,
such
donor
sites
and
collection
methods,
are
also
explored
here.
By
synthesizing
key
advances,
we
propose
research
directions
end.
We
aim
accelerate
development
of
more
effective
exosome-based
therapies
highlight
underexplored
rapidly
evolving
field.
Язык: Английский
Recent Progress in Developing Extracellular Vesicles as Nanovehicles to Deliver Carbohydrate-Based Therapeutics and Vaccines
Vaccines,
Год журнала:
2025,
Номер
13(3), С. 285 - 285
Опубликована: Март 7, 2025
Cell-derived,
nanoscale
extracellular
vesicles
(EVs)
have
emerged
as
promising
tools
in
diagnostic,
therapeutic,
and
vaccine
applications.
Their
unique
properties
including
the
capability
to
encapsulate
diverse
molecular
cargo
well
versatility
surface
functionalization
make
them
ideal
candidates
for
safe
effective
vehicles
deliver
a
range
of
biomolecules
gene
editing
cassettes,
therapeutic
proteins,
glycans,
glycoconjugate
vaccines.
In
this
review,
we
discuss
recent
advances
development
EVs
derived
from
mammalian
bacterial
cells
use
delivery
carbohydrate-based
protein
therapeutics
We
highlight
key
innovations
EVs’
design,
characterization,
deployment
treating
diseases
Alzheimer’s
disease,
infectious
diseases,
cancers.
challenges
their
clinical
translation
provide
perspectives
future
within
biopharmaceutical
research
landscape.
Язык: Английский
Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions
Sam Dehghani,
Ozgecan Ocakcı,
Pars Tan Hatipoglu
и другие.
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
Neurodegenerative
diseases
(NDs)
like
Alzheimer’s,
Parkinson’s,
and
ALS
rank
among
the
most
challenging
global
health
issues,
marked
by
substantial
obstacles
in
early
diagnosis
effective
treatment.
Current
diagnostic
techniques
frequently
demonstrate
inadequate
sensitivity
specificity,
whilst
conventional
treatment
strategies
encounter
challenges
related
to
restricted
bioavailability
insufficient
blood–brain
barrier
(BBB)
permeability.
Recently,
exosomes—nanoscale
vesicles
packed
with
proteins,
RNAs,
lipids—have
emerged
as
promising
agents
potential
reshape
therapeutic
approaches
these
diseases.
Unlike
drug
carriers,
they
naturally
traverse
BBB
can
deliver
bioactive
molecules
affected
neural
cells.
Their
molecular
cargo
influence
cell
signaling,
reduce
neuroinflammation,
potentially
slow
neurodegenerative
progression.
Moreover,
exosomes
serve
non-invasive
biomarkers,
enabling
precise
while
allowing
real-time
disease
monitoring.
Additionally,
engineered
exosomes,
loaded
molecules,
enhance
this
capability
targeting
diseased
neurons
overcoming
barriers.
By
offering
enhanced
reduced
immunogenicity,
an
ability
bypass
physiological
limitations,
exosome-based
present
a
transformative
advantage
over
existing
approaches.
This
review
examines
multifaceted
role
of
NDDs,
emphasizing
their
capabilities,
intrinsic
functions,
advanced
vehicles.
Язык: Английский
Delivering RNA through exosomes for cancer therapy
Journal of Nanoparticle Research,
Год журнала:
2025,
Номер
27(4)
Опубликована: Март 20, 2025
Язык: Английский
EMERGING ROLE OF EXOSOMAL microRNA IN OBESITY
Current Opinion in Physiology,
Год журнала:
2025,
Номер
unknown, С. 100827 - 100827
Опубликована: Апрель 1, 2025
Язык: Английский
Exosome-based nanomedicines for digestive system tumors therapy
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Апрель 18, 2025
Digestive
system
tumors
constitute
a
major
subset
of
malignancies,
consistently
ranking
among
the
leading
causes
mortality
globally.
Despite
limitations
inherent
in
current
therapeutic
modalities,
recent
advancements
targeted
therapy
and
drug
delivery
systems
have
led
to
significant
improvements
efficacy
pharmacotherapy
for
digestive
tumors.
In
this
context,
exosomes
-
naturally
occurring
nanoscale
vesicles
emerged
as
promising
candidates
due
their
intrinsic
molecular
transport
capabilities,
superior
biocompatibility,
recognition
tumor
cells.
The
integration
into
cancer
therapeutics
represents
novel
potentially
transformative
approach
treating
tumors,
which
may
drive
further
progress
field.
This
review
comprehensively
examines
sources,
loading
mechanisms,
context
treatment.
Furthermore,
it
discusses
opportunities
challenges
associated
with
exosomes,
offering
insights
future
role
within
armamentarium
against
Язык: Английский
Therapeutic combinations of exosomes alongside cancer stem cells (CSCs) and of CSC-derived exosomes (CSCEXs) in cancer therapy
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Окт. 5, 2024
Язык: Английский
miRNA-124 loaded extracellular vesicles encapsulated within hydrogel matrices for combating chemotherapy-induced neurodegeneration
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
734, С. 150778 - 150778
Опубликована: Окт. 1, 2024
Язык: Английский
Extracellular Vesicles from Mesenchymal Stem Cells: Potential as Therapeutics in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2848 - 2848
Опубликована: Дек. 14, 2024
Background/Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
characterized
by
the
accumulation
of
triglycerides
within
hepatocytes,
which
can
progress
to
more
severe
conditions,
such
as
metabolic
steatohepatitis
(MASH),
may
include
progressive
fibrosis,
leading
cirrhosis,
cancer,
and
death.
This
goal
this
review
highlight
recent
research
showing
potential
mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
in
reducing
key
pathogenic
pathways
MASLD
or
MASH.
Methods:
Relevant
published
studies
were
identified
using
PubMed
with
one
following
search
terms:
MASLD,
MASH,
NAFLD,
NASH,
exosome,
vesicle
(EV),
therapy,
and/or
cells
(MSC).
The
primary
literature
subsequently
downloaded
summarized.
Results:
Using
vitro
vivo
models,
MSC-EVs
have
been
found
counteract
oxidative
stress,
a
significant
contributor
injury
suppress
progression,
including
steatosis,
inflammation,
and,
few
instances,
fibrosis.
Some
these
outcomes
attributed
specific
EV
cargo
components
microRNAs
proteins.
Thus,
enriched
types
molecules
improved
therapeutic
efficacy
for
MASLD/MASH
represent
novel
approach
potentially
halt
reverse
process.
Conclusions:
are
attractive
agents
treating
MASLD/MASH.
Further
necessary
validate
clinical
applicability
human
MASH
patients,
focusing
on
optimizing
delivery
strategies
identifying
that
targeted
components.
Язык: Английский