Locally Injectable, ROS‐Scavenging, and ROS‐/pH‐Responsive Polymeric‐Micelles‐Embedded Hydrogels for Precise Minimally Invasive and Long‐Lasting Rheumatoid Therapy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
characterized
by
synovitis,
bone‐erosion,
and
joint‐destruction.
Here,
we
developed
locally
injectable,
ROS‐scavenging,
ROS‐/pH‐responsive
drug‐delivery
platform
(HC@PTM)
bio‐compositing
of
aldolizing
hyaluronic
acid
(HA)
crosslinked
with
chitosan
(CS),
ROS‐triggered/eliminated
micelles
(PTM)
coupled
the
drug
methotrexate(MTX).
The
PTM
efficiently
eradicate
excessive
ROS
in
RA‐joints,
precisely
triggering
drug‐release
within
inflamed
arthritic‐sites
further
confer
exceptional
antioxidant
origins
to
HC@PTM.
HC@PTM
outstanding
shape‐adaptability
self‐repairing
properties
effectively
conformed
irregular
articular
cartilage
while
resisting
joint‐induced
deformations.
Further,
platform's
pH‐responsive
nature
enables
on‐demand
acidic
synovium,
serving
as
drug‐reservoir
for
precise
sustained
therapeutic
effects.
Extensive
vitro
vivo
investigations
confirm
HC@PTM's
ability
induce
M2
macrophage
polarization,
downregulate
inflammatory
factor
expression,
ameliorate
RA‐microenvironment,
ultimately
achieving
synergistic
outcomes.
This
study
represents
significant
advancements
long‐term
RA‐treatment
through
minimally
invasive
approach,
offering
potential
strategies
novel
precision
medicine.
Язык: Английский
Intelligent Nanomaterials Design for Osteoarthritis Managements
Small Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
Osteoarthritis
(OA)
is
the
most
prevalent
degenerative
joint
disorder,
characterized
by
progressive
degradation,
pain,
and
diminished
mobility,
all
of
which
collectively
impair
patients'
quality
life
escalate
healthcare
expenditures.
Current
treatment
options
are
often
inadequate
due
to
limited
efficacy,
adverse
side
effects,
temporary
symptom
relief,
underscoring
urgent
need
for
more
effective
therapeutic
strategies.
Recent
advancements
in
nanomaterials
nanomedicines
offer
promising
solutions
improving
drug
bioavailability,
reducing
effects
providing
targeted
benefits.
This
review
critically
examines
pathogenesis
OA,
highlights
limitations
existing
treatments,
explores
latest
innovations
intelligent
design
OA
therapy,
with
an
emphasis
on
their
engineered
properties,
mechanisms,
translational
potential
clinical
application.
By
compiling
recent
findings,
this
work
aims
inspire
further
exploration
innovation
nanomedicine,
ultimately
advancing
development
personalized
therapies.
Язык: Английский
Edge advances in nanodrug therapies for osteoarthritis treatment
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 30, 2024
As
global
population
and
lifestyles
change,
osteoarthritis
(OA)
is
becoming
a
major
healthcare
challenge
world.
OA,
chronic
condition
characterized
by
inflammatory
degeneration,
often
present
with
joint
pain
can
lead
to
irreversible
disability.
While
there
currently
no
cure
for
it
commonly
managed
using
nonsteroidal
anti-inflammatory
drugs
(NSAIDs),
glucocorticoids,
glucosamine.
Although
these
treatments
alleviate
symptoms,
difficult
effectively
deliver
sustain
therapeutic
agents
within
joints.
The
emergence
of
nanotechnology,
particularly
in
form
smart
nanomedicine,
has
introduced
innovative
approaches
OA
treatment.
Nanotherapeutic
strategies
offer
promising
advantages,
including
more
precise
targeting
affected
areas,
prolonged
effects,
enhanced
bioavailability,
reduced
systemic
toxicity
compared
traditional
treatments.
nanoparticles
show
potential
as
viable
delivery
system
therapies
based
on
encouraging
lab-based
clinical
trials
results,
remails
considerable
gap
between
current
research
application.
This
review
highlights
recent
advances
nanotherapy
explore
future
pathways
refine
optimize
strategies.
Язык: Английский
Research Progress of Phospholipid Vesicles in Biological Field
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1628 - 1628
Опубликована: Дек. 19, 2024
Due
to
their
high
biocompatibility,
biodegradability,
and
facile
surface
functionalization,
phospholipid
vesicles
as
carriers
have
garnered
significant
attention
in
the
realm
of
disease
diagnosis
treatment.
On
one
hand,
can
function
probes
for
detection
various
diseases
by
encapsulating
nanoparticles,
thereby
enabling
precise
localization
pathological
changes
monitoring
progression.
other
possess
capability
selectively
target
deliver
therapeutic
agents,
including
drug
molecules,
genes
immune
modulators,
affected
sites,
enhancing
sustained
release
these
agents
improving
efficacy.
Recent
advancements
nanotechnology
led
an
increased
focus
on
application
delivery,
biological
detection,
gene
therapy,
cell
mimics.
This
review
aims
provide
a
concise
overview
structure,
characteristics,
preparation
techniques
varying
sizes.
Furthermore,
we
will
summarize
latest
research
developments
regarding
use
nanomedicines
Additionally,
elucidate
potential
facilitating
internalization,
controlled
release,
targeted
delivery
substrates.
Through
this
review,
aspire
enhance
understanding
evolution
within
field,
outline
prospective
research,
address
forthcoming
challenges
associated
with
Язык: Английский