Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 209 - 209
Опубликована: Фев. 4, 2025
This
study
conducted
a
literature
review
by
searching
for
articles
related
to
the
treatment
of
skin
infections/wrinkles
using
nano-delivery
systems
containing
natural
compounds.
The
search
was
in
various
databases
published
last
10
years,
with
strict
inclusion
and
exclusion
criteria.
Of
490
found,
40
were
considered
relevant.
Acne
vulgaris
is
common
dermatological
disorder
characterised
inflammation
sebaceous
glands,
often
resulting
development
pimples,
cysts,
scarring.
Conventional
treatments,
including
antibiotics
topical
retinoids,
frequently
demonstrate
limitations
such
as
side
effects,
resistance,
insufficient
absorption.
Recent
advancements
nanotechnology
have
enabled
creation
innovative
drug-delivery
that
enhance
effectiveness
reduce
adverse
effects
anti-acne
medications.
Polyphenols
flavonoids,
bioactive
compounds
notable
anti-inflammatory,
antioxidant,
antibacterial
properties,
are
recognised
their
therapeutic
acne
treatment.
However,
practical
application
hindered
solubility,
stability,
bioavailability.
incorporation
these
into
nanoparticle-based
delivery
has
shown
promise
resolving
challenges.
Various
nanoparticle
platforms,
lipid-based
nanoparticles,
polymeric
solid
lipid
evaluated
ability
improve
controlled
release,
targeted
polyphenols
flavonoids
skin.
advent
polyphenol
flavonoid-loaded
nanoparticles
marks
new
therapy
era.
Язык: Английский
Formulation Development of Natural Polymeric Nanoparticles, In Vitro Antiaging Evaluation, and Metabolite Profiling of Toona sinensis Leaf Extracts
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 288 - 288
Опубликована: Фев. 20, 2025
Background/Objectives:
Natural
polymer
nanoparticles
have
potential
as
delivery
systems,
can
enhance
pharmacological
activity,
and
improve
stability
in
the
cosmetic
field.
In
this
research,
we
implemented
a
development
approach
for
chitosan–alginate
chitosan–pectin
nanoparticles.
This
study
aimed
to
investigate
effect
of
formulation,
process
variables,
vitro
antiaging
evaluation,
metabolite
profiling
Toona
sinensis
leaf
extracts.
Methods:
Polymeric
been
prepared
using
ionic
gelation
method
(Temperature
=
40
°C,
time
1
h
speed
1000
rpm),
evaluation
Neutrophil
Elastase
Inhibitor
Screening
Kit
method,
analysis
with
UHPLC–HRMS.
Results:
Research
results
found
that
SLE
EAFSL
good
stable
characteristics
before
after
storage
climatic
chamber
3
months
are
FIIA-NPSLE
(0.75%
chitosan
1.25%
Alginate),
FIP-NPSLE
(1%
0.5%
Pectin),
FIIA-NPEAFSL
FIIIP-NPEAFSL
(0.125%
0.375%
Alginate).
Chitosan–alginate
polymers,
such
FIIA-NPEAFSL,
higher
inhibition
elastase
enzyme
than
FIIA-NPSLE,
%
(IC50)
being
87.30%,
while
IC50
is
39.40%.
Meanwhile,
FIP-NPSLE,
lower
compared
polymer,
an
27.28%
39.53%.
polymers
resulted
significant
PDI
during
from
1.3
1.9,
zeta
values
were
very
low,
ranging
−11
mV
−27
mV.
Metabolite
UHPLC–HRMS
on
T.
extracts
revealed
main
compounds
contained
glycitein,
quercetin,
quercetin-3β-D-glucoside,
kaempferol,
ellagic
acid,
which
has
agent.
Conclusions:
It
be
concluded
chitosan,
alginate,
pectin
encapsulating
into
same
variables
affect
activity
enzymes.
Further
research
will
develop
these
nanohydrogels
activity.
Язык: Английский
Phytosomes: A Promising Nanocarrier System for Enhanced Bioavailability and Therapeutic Efficacy of Herbal Products
Phytomedicine Plus,
Год журнала:
2025,
Номер
unknown, С. 100779 - 100779
Опубликована: Март 1, 2025
Язык: Английский
Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 464 - 464
Опубликована: Апрель 2, 2025
Natural
substances,
especially
those
derived
from
plants,
exhibit
a
diverse
range
of
therapeutic
benefits,
such
as
antioxidant,
anti-inflammatory,
anticancer,
and
antimicrobial
effects.
Nevertheless,
their
use
in
clinical
settings
is
frequently
impeded
by
inadequate
solubility,
limited
bioavailability,
instability.
Nanovesicular
carriers,
liposomes,
niosomes,
ethosomes,
transferosomes,
transethosomes,
cubosomes,
have
emerged
innovative
phytochemical
delivery
systems
to
address
these
limitations.
This
review
highlights
recent
developments
vesicular
nanocarriers
for
delivery,
emphasizing
preparation
techniques,
composition,
applications,
the
future
potential
systems.
Phytosomes,
along
with
key
advantages
various
are
extensively
described.
Various
vitro
vivo
characterization
techniques
utilized
evaluating
nanovesicular
carriers
summarized.
Completed
trials
patents
granted
nanovesicles
encapsulating
phytochemicals
designed
systemic
tabulated.
Phytochemical
via
faces
challenges
low
stability,
active
loading,
scalability
issues,
high
production
costs.
Additionally,
immune
clearance
regulatory
hurdles
hinder
application,
requiring
improved
carrier
design
formulation
techniques.
Язык: Английский
The potential of medicinal plants in tuberculosis treatment: Indigenous plants used by the Anak Dalam tribe of Jambi, Indonesia
South African Journal of Botany,
Год журнала:
2025,
Номер
180, С. 688 - 709
Опубликована: Апрель 3, 2025
Язык: Английский
Phytosomes as a New Frontier and Emerging Nanotechnology Platform for Phytopharmaceuticals: Therapeutic and Clinical Applications
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
ABSTRACT
A
complete
investigation
into
phytosome‐based
formulations
and
innovative
nanotechnology
is
presented
in
this
review.
This
aims
to
improve
the
bioavailability
therapeutic
effectiveness
of
herbal
components.
Phytosomes
can
significantly
increase
solubility,
absorption,
stability
compared
standard
by
encapsulating
active
phytoconstituents
phospholipid
complexes.
unique
ability
phytosomes
overcome
limits
traditional
a
potential
game
changer
medicine.
study
highlights
different
uses
across
various
health
disorders,
such
as
neurodegenerative
illnesses,
inflammatory
conditions,
diabetes,
cardiovascular
diseases,
wound
healing.
The
review
also
discusses
treating
infectious
diseases
improving
delivery
bioactive
compounds
that
have
improved
anticancer
efficacy
antibacterial
properties.
Despite
emergence
numerous
groundbreaking
discoveries,
substantial
barriers
remain
hinder
their
widespread
application.
Challenges
must
be
addressed
include
stability,
large‐scale
manufacture,
regulatory
hurdles,
limited
clinical
translation.
examines
limitations
present
practice,
mainly
focusing
on
variability
bioavailability.
crucial
need
for
future
research
phytosomes,
engaging
researchers
emphasizing
continuous
evolution
promising
area
Язык: Английский
The Toxicological Profile of Active Pharmaceutical Ingredients–Containing Nanoparticles: Classification, Mechanistic Pathways, and Health Implications
Pharmaceuticals,
Год журнала:
2025,
Номер
18(5), С. 703 - 703
Опубликована: Май 9, 2025
Nanotechnology
is
the
manipulation
of
matter
on
an
atomic
and
molecular
scale,
producing
a
lot
new
substances
with
properties
that
are
not
necessarily
easily
expected
based
present
knowledge.
produces
unique
can
be
beneficial
or
harmful
depending
their
biocompatibility
distribution.
Understanding
nanomaterial
toxicity
essential
to
ensure
safe
application
in
biological
environmental
applications.
This
review
aims
provide
comprehensive
overview
nanoparticle
toxicity,
focusing
physicochemical
properties,
mechanisms
cellular
uptake,
potential
health
risks.
Key
factors
influencing
include
particle
size,
shape,
concentration,
aspect
ratio,
crystallinity,
surface
charge,
dissolution,
agglomeration.
Nanoparticles
induce
oxidative
stress
inflammation,
contributing
adverse
effects
when
inhaled,
ingested,
applied
skin.
However,
may
limited
just
these
pathways,
as
they
also
exhibit
other
toxic
such
activation
apoptotic
pathway
mitochondrial
damage.
By
summarizing
current
knowledge
aspects,
this
article
intends
support
development
nanoparticles
safer
way
for
future
Язык: Английский