Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents
Molecules,
Год журнала:
2025,
Номер
30(2), С. 207 - 207
Опубликована: Янв. 7, 2025
The
scientific
interest
in
the
chemical
modification
of
chitosan
to
increase
its
solubility
and
application
has
led
conjugation
with
Schiff
bases,
which
are
interesting
scaffolds
endowed
diverse
biological
properties.
resultant
chitosan-based
bases
(CSBs)
widely
studied
literature
due
myriad
activities
exerted,
both
catalytic
biological,
including
anticancer,
anti-inflammatory,
antioxidant,
especially
antimicrobial
ones.
Antimicrobial
resistance
(AMR)
is
one
major
public
health
challenges
twenty-first
century
because
it
represents
a
threat
prevention
treatment
growing
number
bacterial,
parasitic,
viral,
fungal
infections
that
no
longer
treatable
available
drugs.
Thus,
this
review,
we
present
brief
outline
CSBs
as
well
their
complexes
metals,
particular
focus
on
recent
regarding
effect
these
captivating
derivatives.
Язык: Английский
Staphylococcal Drug Resistance: Mechanisms, Therapies, and Nanoparticle Interventions
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 1007 - 1033
Опубликована: Фев. 1, 2025
The
increasing
incidence
of
antibiotic
resistance
in
Staphylococcus
aureus
(S.
aureus)
poses
a
substantial
threat
to
global
public
health.
In
recent
decades,
the
evolution
bacteria
and
misuse
antibiotics
have
led
progressive
development
drug
S.
aureus,
resulting
worldwide
rise
methicillin-resistant
(MRSA)
infection
rates.
Understanding
molecular
mechanisms
underlying
staphylococcal
resistance,
treatments
for
infections,
efficacy
nanomaterials
addressing
multi-drug
is
crucial.
This
review
explores
mechanisms,
which
include
limiting
uptake,
target
modification,
inactivation
through
production
degrading
enzymes,
active
efflux
drugs.
It
also
examines
current
therapeutic
strategies,
such
as
combination
therapy,
phage
monoclonal
antibody
nanoparticle
with
particular
emphasis
on
role
silver-based
nanomaterials.
Nanoparticles
possess
ability
overcome
offering
novel
avenue
management
drug-resistant
bacteria.
demonstrated
potent
antibacterial
activity
against
various
including
cell
membrane
disruption,
generation
reactive
oxygen
species
(ROS),
inhibition
essential
cellular
processes.
highlights
need
further
research
optimize
design,
enhance
their
potency,
ensure
biocompatibility
biodegradability.
ultimately
concludes
by
emphasizing
importance
multifaceted
approach
treatment,
new
antibiotics,
investment
stewardship
programs
prevent
misuse,
exploration
natural
compounds
bacteriocins
potential
antimicrobial
agents.
Язык: Английский
Dual-Loaded Chitosan-Based Nanoparticles: A Novel approach for treating polymicrobial osteomyelitis
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125480 - 125480
Опубликована: Март 1, 2025
Developing
innovative
approaches
to
target
osteomyelitis
caused
by
polymicrobial
infections
remains
a
significant
therapeutic
challenge.
In
this
study,
monodispersed
chitosan
nanoparticles
co-loaded
with
antibacterial
(minocycline)
and
antifungal
(voriconazole)
agents
were
successfully
prepared.
Minocycline
presented
higher
encapsulation
efficiency
as
compared
voriconazole.
Thermostability
analysis
suggested
interactions
between
the
drugs
within
dual-delivery
system,
potentially
limiting
voriconazole
release.
The
dual-loaded
exhibited
in
vitro
anti-biofilm
activity,
achieving
up
90%
reduction
biofilms
of
S.
aureus
C.
albicans.
Additionally,
showed
cytocompatibility
human
osteoblast
cell
line.
These
findings
highlight
potential
chitosan-based
nanoparticle
system
address
critical
gap
treatment
targeting
both
bacterial
fungal
pathogens.
Язык: Английский
Addressing the challenges of infectious bone defects: a review of recent advances in bifunctional biomaterials
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 29, 2025
Infectious
bone
defects
present
a
substantial
clinical
challenge
due
to
the
complex
interplay
between
infection
control
and
regeneration.
These
often
result
from
trauma,
autoimmune
diseases,
infections,
or
tumors,
requiring
nuanced
approach
that
simultaneously
addresses
promotes
tissue
repair.
Recent
advances
in
engineering
materials
science,
particularly
nanomaterials
nano-drug
formulations,
have
led
development
of
bifunctional
biomaterials
with
combined
osteogenic
antibacterial
properties.
offer
an
alternative
traditional
grafts,
minimizing
complications
such
as
multiple
surgeries,
high
antibiotic
dosages,
lengthy
recovery
periods.
This
review
examines
repair
mechanisms
infectious
microenvironment
highlights
various
foster
both
anti-infective
processes.
Emerging
design
strategies
are
also
discussed
provide
forward-looking
perspective
on
treating
clinically
significant
outcomes.
Язык: Английский
Chitin, Chitosan and Its Derivatives: Antimicrobials and/or Mitigators of Water
Macromol—A Journal of Macromolecular Research,
Год журнала:
2025,
Номер
5(2), С. 15 - 15
Опубликована: Апрель 8, 2025
Antimicrobial
resistance
(AMR)
is
a
major
global
health
problem,
exacerbated
by
the
excessive
and
inappropriate
use
of
antibiotics
in
human
medicine,
animal
care
agriculture.
Therefore,
new
strategies
compounds
are
needed
to
overcome
this
issue.
In
view,
it
may
be
appropriate
reconsider
existing
biomaterials
alleviate
antibiotic
overuse.
Chitin,
naturally
abundant
amino
mucopolysaccharide,
poly-β-1,
4-N-acetylglucosamine
(GlcNAc).
It
white,
hard,
inelastic,
nitrogenous
polysaccharide
source
surface
pollution
coastal
areas.
Chitosan
derives
from
partial
N-deacetylation
chitin
originates
shells
crustaceans
fungi
cell
walls.
nontoxic
natural
antimicrobial
polymer
approved
GRAS
(Generally
Recognized
as
Safe
United
States
Food
Drug
Administration).
Chitin
chitosan,
non-toxic
biopolymers,
useful
for
wastewater
treatment
remove
pollutants,
such
pharmaceuticals,
heavy
metals
dyes.
The
described
features
make
these
biopolymers
intriguing
investigated
their
application
antibacterials.
Язык: Английский
Natural Materials in Regenerative Orthopaedics: A Historical Perspective
Regenerative medicine and dentistry.,
Год журнала:
2025,
Номер
unknown, С. 7 - 7
Опубликована: Апрель 16, 2025
Review
Natural
Materials
in
Regenerative
Orthopaedics:
A
Historical
Perspective
Olivia
Vasilev
1,*,
David
Campbell
2,3
and
Ruurd
L.
Jaarsma
4
1
Endeavour
College,
Mawson
Lakes,
Adelaide
5095,
Australia
2
Centre
of
Orthopaedics
Trauma
Research,
University
Adelaide,
5000,
3
Wakefield
Orthopaedic
Clinic,
120
Angus
Street,
Department
&
Surgery,
Flinders
Medical
Centre,
5042,
*
Correspondence:
[email protected]
Received:
18
March
2025;
Revised:
31
Accepted:
April
Published:
16
2025
Abstract:
The
use
natural
materials
regenerative
orthopaedics
has
undergone
significant
evolution
over
many
centuries.
What
began
as
the
simple
animal
sinews
plant
fibers
for
stabilizing
fractures
now
expanded
into
sophisticated
biomaterials
that
are
integral
to
modern
medicine.
substances
like
collagen,
silk
fibroin,
chitosan,
cellulose
crucial
tissue
engineering,
providing
innovative
bone
cartilage
regeneration
solutions.
Despite
their
promise,
face
challenges
such
mechanical
limitations,
biodegradation
rates,
immunogenicity.
Additionally,
advancements
3D
printing
allow
replacement
complex
defects,
particularly
trauma
tumour
cases,
but
these
remain
non-biological
solutions
lack
permanent
integration
with
host
tissues.
emergence
hybrid
materials—combining
synthetic
components—offers
new
opportunities
enhance
biomechanical
properties
biocompatibility.
Furthermore,
emerging
technologies
gene
editing
bioactive
scaffolds
paving
way
more
personalized
approaches.
In
this
review
paper,
we
will
explore
historical
progression
materials,
current
applications,
must
be
overcome
maximize
therapeutic
potential
orthopaedic
Ethical
sustainability
considerations
also
discussed.
concludes
authors’
vision
future
field.
Язык: Английский