Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 28, 2025

Immunosenescence, the age-associated decline of immune system, is pivotal in fostering drug resistance within tumor microenvironment (TME). The accumulation senescent cells and release pro-inflammatory senescence-associated secretory phenotype (SASP) factors create a milieu that supports survival undermines therapeutic efficacy. Traditional cancer treatments often fail to address this underlying issue, leading suboptimal outcomes. This article proposes an innovative strategy overcome immunosenescence-induced through nanoparticle-mediated delivery herbal-derived natural products (HDNPs), which possess senolytic immunomodulatory properties capable clearing rejuvenating function. Nanoparticle systems enhance these compounds' stability, bioavailability, targeted TME cells. By harnessing synergistic effects HDNPs nanotechnology, approach offers novel multifaceted solution therapy. It holds potential restore surveillance, reduce pro-survival signaling cells, efficacy conventional treatments. paradigm shift emphasizes importance addressing immunosenescence as target paves way for more effective personalized interventions.

Язык: Английский