International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136831 - 136831
Опубликована: Окт. 23, 2024
Язык: Английский
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Язык: Английский
Процитировано
2
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
15
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140934 - 140934
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
1
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер unknown, С. 114477 - 114477
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
6
The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Triple-negative breast cancer (TNBC) represents a highly aggressive and prognostically unfavorable subtype of cancer, characterized by the absence common hormone receptors, which renders conventional therapies largely ineffective. This review comprehensively examines molecular clinical characteristics TNBC, underscoring substantial challenges inherent in its treatment innovative potential targeted nanoprobes advancing both diagnostic therapeutic paradigms. Through modification targeting molecules, can deliver agents specific to TNBC cells, thus significantly improving sensitivity modalities efficacy interventions. Our discussion systematically explores application various molecules their advantages limitations. In addition, this presents series multifunctional that are designed perform functions, providing synergistic approach TNBC. These advanced enable precise tumor localization while monitoring response real time, facilitating more personalized dynamic regimen. The major obstacles encountered during translation discussed detail. use leap forward medicine for current research efforts will continue refine these technologies improve applicability.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 142 - 142
Опубликована: Янв. 21, 2025
Glioblastoma’s (GB) complex tumor microenvironment (TME) promotes its progression and resistance to therapy. A critical component of TME is the extracellular matrix (ECM), which plays a pivotal role in promoting tumor’s invasive behavior aggressiveness. Nanotechnology holds significant promise for GB treatment, with potential address challenges posed by both blood-brain barrier ECM. By enabling targeted delivery therapeutic diagnostic agents, nanotechnology offers prospect improving treatment efficacy accuracy at site. This review provides comprehensive exploration GB, including epidemiology, classification, current strategies, alongside intricacies TME. It highlights nanotechnology-based focusing on nanoparticle formulations such as liposomes, polymeric nanoparticles, gold have shown Furthermore, it explores how different emerging strategies modulate ECM overcome high density, restricts drug distribution within tumors. emphasizing intersection ECM, this underscores an innovative approach advancing treatment. addresses limitations therapies, identifies new research avenues, emphasizes improve patient outcomes.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216554 - 216554
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 4, 2025
Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-based nanobattery (termed as IRD) with cascade-charged (O2), ROS, photodynamic-induced coordination-driven self-assembly transition-metal Ru, photosensitizer indocyanine green (ICG), organic ligand dithiobispropionic acid (DTPA). Then, IRD camouflaged macrophage membranes to obtain IRD@M) targeting immune evasion capabilities. Upon intravenous administration, IRD@M core-shell structure, nano diameter, good stability can specifically hoard in tumor location internalize into cells. disassembly triggered GSH, the released Ru³⁺ not only catalyzes conversion endogenous hydrogen peroxide (H₂O₂) O₂ alleviate hypoxia reduce expression hypoxia-inducible factor-1α (HIF-1α), but also generates hydroxyl radicals (·OH) elevate intracellular ROS levels. This process significantly enhances photodynamic therapy (PDT) efficacy ICG. Meanwhile, DTPA downregulate overexpressed GSH elimination deriving from PDT exchange reaction thiol-disulfide bond. It found that alleviating hypoxic microenvironment synergistically efficacy, which turn cascades recharge subsequent response, improving activating systemic tumor-specific immunity. Notably, vitro vivo experimental results jointly confirm such cascade-recharged macrophage-biomimetic Ru-based achieve an obvious while minimized side effect. Taken together, this work highlights promising strategy for simple, flexible, effective immunogenic cell death (ICD) agents within PDI.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 385 - 385
Опубликована: Март 18, 2025
Background: Glutathione (GSH) is an essential antioxidant that protects against oxidative stress, but its oral bioavailability below 1% due to enzymatic degradation and poor gastrointestinal absorption. Improving the of GSH could significantly enhance therapeutic efficacy. Methods: This study synthesised analogues with chemical modifications improve bioavailability. Seven derivatives were designed: three altered stereochemistry (1.62, 1.63, 1.64) N-methylated (1.65, 1.70, 1.71), alongside a native (1.61). The via Fmoc-solid-phase peptide synthesis, they characterised using reverse-phase high-performance liquid chromatography (RP-HPLC), electrospray ionisation mass spectrometry (ESI-MS), Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) spectroscopy. Their toxicity was assessed on Caco-2 cells for viability, their activity UVA-irradiated fibroblast cells, resistance, interactions GSH-metabolising enzymes. Results: Among tested analogues, cysteine Compound (1.70) emerged as most promising candidate. 1.70 demonstrated superior resistance degradation, well showing enhanced cell viability improved activity. In vivo studies revealed 16.8-fold increase in plasma half-life (t½) 16.1-fold compared GSH. Conclusions: Chemical modification strategies, particularly N-methylation GSH, present viable approach enhancing showed significant potential applications, warranting further investigation development clinical settings.
Язык: Английский
Процитировано
0
Applied Materials Today, Год журнала: 2025, Номер 44, С. 102690 - 102690
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0