Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216489 - 216489

Опубликована: Фев. 3, 2025

Язык: Английский

---

Formulation of Ethyl Cellulose Nanoparticles Encapsulated with Osthole Provides Long-Lasting Plant Protection against a Major Pest Mite

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

The broader use of botanical pesticides has been limited by shorter residual activity on plants, slower onset action, and higher costs compared with conventional pesticides. These challenges could be overcome the development simple, cost-effective, long-lasting preventive nanocomposites for In this study, we successfully developed a low-cost ethyl cellulose (EC)-based delivery system pesticide osthole (OST), designed to provide extended protection against Tetranychus urticae infestations. A comparative analysis three (graphene oxide (GO)-OST, EC-OST, chitosan (CS)-OST) revealed that EC-OST exhibited superior thermal stability, UV resistance, controlled release OST payload, strong acaricidal activity. degradation leaf surfaces was reduced encapsulation in EC, while its penetration into plant tissues improved. When applied leaves, an increase T. mortality, reduction reproduction egg adhesion, impairment feeding behavior through searching times were observed. peak occurrence infestation delayed 10 days following application reducing damage protecting plants more than 20 days. This nanoinsecticide allows low-frequency application, farmers' production costs, increasing profitability, thereby offering great potential promoting protection.

Язык: Английский

---

Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 4235 - 4255

Опубликована: Апрель 1, 2025

α-Solanine (α-Sol) shows promise for pancreatic cancer (PC) treatment by inhibiting PC cell proliferation, migration, and invasion. However, its clinical application is hindered poor tumor targeting, significant toxicity, undesirable pharmacokinetics. To address these issues, this study developed a nanoparticle delivery system (PBSO NPs) using bovine serum albumin as carrier, with polyallylamine hydrochloride surface modification to enhance α-Sol delivery. PBSO NPs were characterized transmission electron microscopy, dynamic light scattering, size analyzers, Fourier-transform infrared spectroscopy. Their in vitro drug release profile cellular uptake capabilities evaluated. Furthermore, experiments conducted mouse cells (Panc02) investigate the effects of on Panc02 viability, invasion, apoptosis. Additionally, xenograft model was established vivo explore impact growth. This successfully favorable morphology physiological stability, capable enhancing uptake. In demonstrated that significantly inhibited invasion while promoting Moreover, enhanced inhibitory cells. further confirmed improved therapeutic efficacy against partially reducing toxicity. exhibited good biocompatibility. apoptosis, thereby suppressing progression PC. provides promising strategy treatment.

Язык: Английский

---

Gold@Mesoporous Polydopamine Nanocomposite Hydrogel Loaded with Estrogen for the Treatment of Skin Photoaging

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 4571 - 4587

Опубликована: Апрель 1, 2025

Topical application of 17β-estradiol (E2) has been shown to improve various hallmark features skin aging, including enhancing elasticity and hydration, reducing wrinkles, promoting collagen synthesis. However, the role estrogen in UVB-induced photoaging remains unclear. Furthermore, E2's clinical is limited by issues such as bioavailability potential adverse effects. Therefore, this study aims explore E2 prepare a gold (Au)@mesoporous polydopamine (mPDA)-hyaluronic acid (HA)/carboxymethyl chitosan (CMCS) nanoparticle composite hydrogel (Au/E2@mPDA-HCG) for treatment photoaging. This successfully fabricated mPDA with well-defined mesoporous structure incorporated Au NPs into mesopores using an situ growth method, thereby constructing Au@mPDA loaded E2. Subsequently, Au/E2@mPDA were embedded HA/CMCS develop Au/E2@mPDA-HCG hydrogel. The was characterized through vitro vivo experiments, its efficacy improving evaluated. revealed that deficiency significantly exacerbates photoaging, likely mechanisms closely associated increased oxidative stress reduced production. Moreover, demonstrated favorable morphological characteristics biocompatibility. In experimental results indicated effectively enhanced therapeutic treating evidenced significant mitigation inflammatory responses, along promotion conclusion, suggests combination Au@mPDA@HCG nanocomposite offers promising strategy

Язык: Английский

---

ROS responsive nanozyme loaded with STING silencing for the treatment of sepsis-induced acute lung injury

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 493, С. 117155 - 117155

Опубликована: Ноя. 12, 2024

Язык: Английский

---