The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

и другие.

Developmental medico-life-sciences, Год журнала: 2024, Номер 1(10), С. 4 - 22

Опубликована: Дек. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Язык: Английский

Advances in human umbilical cord mesenchymal stem cells-derived extracellular vesicles and biomaterial assemblies for endometrial injury treatment DOI
Wanyu Zhang,

Han-Bi Wang,

Chengyan Deng

и другие.

World Journal of Stem Cells, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 17, 2025

Endometrial injury caused by repeated uterine procedures, infections, inflammation, or artery dysfunction can deplete endometrial stem/progenitor cells and impair regeneration, thereby diminishing receptivity evidently lowering the live birth, clinical pregnancy, embryo implantation rates. Currently, safe effective treatment methods gene-targeted therapies are unavailable, especially for severe injury. Umbilical cord mesenchymal stem their extracellular vesicles characterized simple collection, rapid proliferation, low immunogenicity, tumorigenicity, along with involvement in regulating angiogenesis, immune response, cell apoptosis inflammatory fibrosis, Therefore, these hold broad potential application repair. This article reviewed recent research on human umbilical as well repairing

Язык: Английский

Процитировано

0
Development of regenerative therapies targeting fibrotic endometrium in intrauterine adhesion or thin endometrium to restore uterine function DOI
Guangfeng Zhao, Jianwu Dai, Yali Hu

и другие.

Science China Life Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0
The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

и другие.

Developmental medico-life-sciences, Год журнала: 2024, Номер 1(10), С. 4 - 22

Опубликована: Дек. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Язык: Английский

Процитировано

1