Expert Review of Cardiovascular Therapy, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Introduction Hypertension is very common and a major risk factor for cardiovascular disease, heart failure, chronic kidney strokes, death. However, at present only 14% of patients developing countries have their blood pressure (BP) well controlled. The causes the failure to control BP are multiple one them could be formulation antihypertensive drugs.
Язык: Английский
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Язык: Английский
Процитировано
3
SLAS TECHNOLOGY, Год журнала: 2025, Номер unknown, С. 100243 - 100243
Опубликована: Янв. 1, 2025
Chronic kidney disease (CKD) significantly increases the risk of CVD diseases, particularly among elderly patients. Understanding interaction between several biomarkers and cardiovascular (CVD) risks is crucial for improving patient outcomes tailoring personalized treatment strategies. There much more to learn about intricate relationship in CKD Research aims harness natural language processing (NLP) strategies investigate patients with CKD. This research examined how changes baseline values four novel classic cardiac relate danger CVD, all-cause death a large cohort Initially, medical data were collected from EHR NLP technique, such as Named Entity Recognition (NER), used extract relevant factors data. Statistical techniques applied examine associations risks. The predictive models, using combination structured NLP-extracted features demonstrated improved accuracy forecasting compared traditional methods. investigation highlights critical role specific like PTH FGF-23 predicting outcomes, providing insights into possibility better management enhancing models this high-risk population.
Язык: Английский
Процитировано
1
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1491 - 1507
Опубликована: Фев. 1, 2025
Background and Aim: Over the past years, noble metal-based nanoparticles have been extensively investigated for their applications in nanomedicine. However, there are still concerns about potential adversities that these may present an organism. In particular, whether they could cause exacerbated cytotoxic response susceptible tissues due to damage or disease, such as heart, liver, spleen, kidneys. this regard, study aims evaluate cytotoxicity of mono- bimetallic gold silver (Au:Ag NPs) on healthy hypertrophic cardiac H9c2 cells, metabolically activated macrophages derived from U937 cells. The main objective work is explore susceptibility cells exposure Au:Ag NPs conditions representing cardiometabolic diseases. Methods: were synthesized different molar ratios (Au:Ag, 100:0, 75:25, 50:50, 25:75, 0:100) using starch a capping reducing agent. Their physicochemical properties characterized through UV-vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) dynamic light scattering (DLS), ζ-potential measurements, transmission electron microscopy (TEM). Moreover, effect nanoparticle was measured by analyzing cellular vitality, loss mitochondrial membrane (∆Ψm), production reactive oxygen species (mROS). Results: did not affect cell vitality macrophages. On contrary, showed decreased metabolism when exposed with higher Ag concentrations. Furthermore, more same compared non-hypertrophic counterparts, presented pronounced ∆Ψm. addition, increased mROS regulated death both Conclusion: conclusion, low doses high-Ag load produced being susceptible. These results suggest prone presence opens door nanotoxicity biological disease conditions. Keywords: cardiovascular cardiomyoblasts, nanoparticles,
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1747 - 1768
Опубликована: Фев. 1, 2025
Abstract: Myocardial infarction (MI) is the leading cause of mortality from cardiovascular diseases. Rapid diagnosis and effective treatment are critical for improving patient prognosis. Although current diagnostic therapeutic approaches have made significant progress, they still face challenges such as ischemia-reperfusion injury, microcirculatory disorders, adverse cardiac remodeling, inflammatory responses. These issues highlight urgent need innovative solutions. Nanomaterials, with their diverse types, excellent physicochemical properties, biocompatibility, targeting capabilities, offer promising potential in addressing these challenges. Advances nanotechnology increasingly drawn attention to application nanomaterials both diagnosing treating myocardial infarction. We summarize pathophysiological mechanisms staging systematically review applications MI diagnosis, including detection biomarkers imaging techniques, well treatment, encompassing anti-inflammatory effects, antioxidant stress, inhibition fibrosis, promotion angiogenesis, conduction repair. analyze existing provide insights into future research directions Specifically, we discuss rigorous safety assessments, long-term efficacy studies, development robust strategies translating laboratory findings clinical practice. In conclusion, holds promise a new strategy Its enhance outcomes revolutionize care makes it an exciting area practical real-world settings. Keywords: infarction, nanomaterials, nanoparticles,
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 10319 - 10320
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
Life Sciences, Год журнала: 2024, Номер 358, С. 123199 - 123199
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
Expert Review of Cardiovascular Therapy, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Introduction Hypertension is very common and a major risk factor for cardiovascular disease, heart failure, chronic kidney strokes, death. However, at present only 14% of patients developing countries have their blood pressure (BP) well controlled. The causes the failure to control BP are multiple one them could be formulation antihypertensive drugs.
Язык: Английский
Процитировано
0