Antitumor Research Based on Drug Delivery Carriers: Reversing the Polarization of Tumor-Associated Macrophages

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

The development of malignant tumors is a complex process that involves the tumor microenvironment (TME). An immunosuppressive TME presents significant challenges to current cancer therapies, serving as key mechanism through which cells evade immune detection and play crucial role in progression metastasis. This impedes optimal effectiveness immunotherapeutic approaches, including cytokines, checkpoint inhibitors, vaccines. Tumor-associated macrophages (TAMs), major component tumor-infiltrating cells, exhibit dual functionalities: M1-like TAMs suppress tumorigenesis, while M2-like promote growth Consequently, various nanocarriers aimed at polarizing phenotypes distinct mechanisms has emerged promising therapeutic strategy inhibit escape enhance antitumor responses. Review covers origin types TAMs, common pathways regulating macrophage polarization, progression, strategies targeting aiming provide comprehensive understanding guidance for future research clinical applications.

Язык: Английский

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Manganese Dioxide-based In Situ Vaccine Boosts Antitumor Immunity via Simultaneous Activation of Immunogenic Cell Death and the STING Pathway

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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A hollow nanozyme-based multifunctional platform enhances sonodynamic–chemodynamic-induced ferroptosis for cancer therapy

RSC Advances, Год журнала: 2025, Номер 15(12), С. 9408 - 9419

Опубликована: Янв. 1, 2025

The HMnO 2 –VC@mPEG–Ce6 nanoplatform synergizes sono–chemodynamic therapy with ferroptosis induction via hypoxia alleviation, GSH depletion, and GPX4 inhibition, achieving tumor suppression in prostate cancer minimal systemic toxicity.

Язык: Английский

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NDP@MnO₂ hydrogel combined with photothermal therapy for postoperative anti-recurrence treatment of pancreatic cancer

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Surgical resection remains a potentially curative treatment option for pancreatic cancer (PC). However, the high rate of local tumor recurrence and poor prognosis severely limit its therapeutic efficacy. In this study, we report an injectable thermosensitive hydrogel platform (designated as NDP@MnO₂ hydrogel) that exhibits excellent biocompatibility, photothermal performance, wet adhesion properties, specifically designed precise post-operative therapy. This system innovatively combines shear-thinning injectability, dopamine-mediated tissue adhesion, MnO₂-enhanced ablation capabilities. By precisely targeting hyperthermia to moist irregular margins during sol-gel transition subsequent exposure 808 nm laser, approach can effectively selectively eliminate residual cells while minimizing collateral damage adjacent healthy tissues. Notably, pre-clinical studies have demonstrated significantly reduces locoregional in models, thereby offering promising solution critical issue postoperative recurrence.

Язык: Английский

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Insight into the interaction of MnO2@Polyaniline composite with bovine serum albumin

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142395 - 142395

Опубликована: Апрель 1, 2025

Язык: Английский

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Golden insights for exploring cancer: delivery, from genes to the human body using bimetallic Au/Ag nanostructures

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Май 25, 2025

Sweeping contact with cancer continues to rise globally, which has led advanced research on new treatment approaches; nanotechnology become crucial targeted therapy. Within the intimate of nanomaterials, Au/Ag nanostructures have emerged as highly attractive because their distinctive desirable characteristics and prospective roles in diagnosis well The developed revealed remarkable biocompatibility, optically recursive alteration, magnificently improved therapeutic effects gold silver conjunction each other. This review addresses molecular systemic aspects research, including impact genetic pathways use administration human organism. We explain some related mechanisms action, such photothermal therapy (PTT), photodynamic (PDT), drug delivery systems where they display potential benefits towards offering a more approach fewer side effects. latest development shown that prospect real-time imaging biomarker identification, owing this are being viewed tool for individualized treatment. However, there still limitations: challenges scaling up, biological safety, bringing it clinic. It is therefore incumbent upon these managements overcome hurdles optimize impact. As result, current findings briefly reviewed, directions discussed support revolutionary role

Язык: Английский

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Insight into the Interaction of Mno2@Polyaniline Composite with Bovine Serum Albumin

Опубликована: Янв. 1, 2024

Язык: Английский

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