Enhancing Drug Solubility, Bioavailability, and Targeted Therapeutic Applications through Magnetic Nanoparticles

Molecules, Год журнала: 2024, Номер 29(20), С. 4854 - 4854

Опубликована: Окт. 13, 2024

Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor across varying physiological conditions often leads reduced absorption inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through use nanomaterials magnetic nanoparticles, offers innovative solutions enhance comprehensive focuses on recent advancements approaches nanotechnology. We highlight both successes remaining this field, emphasizing role continued innovation. Future research should prioritize developing universal solutions, conducting interdisciplinary research, leveraging personalized nanomedicine address biological variability.

Язык: Английский

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A Comprehensive Review on the Green Synthesis of Nanoparticles: Advancements in Biomedical and Environmental Applications

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Язык: Английский

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The Integration of Cholesterol‐Polyethylene Glycol‐Folic Acid Conjugate and Iron Oxide Nanoparticles for A Multi Targeted and Stimuli Responsive Drug Delivery System of Quercetin

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

ABSTRACT This research focused on developing a multi‐targeted, stimuli‐responsive drug delivery system by integration of iron oxide nanoparticles (IONPs) and Cholesterol‐Polyethylene glycol‐Folic acid conjugate (CPF) to enhance the poorly water‐soluble drugs. Oleic (OA) coated (OCION) were synthesized subsequently functionalized with CPF form OCION–CPF. Quercetin (QCT), model soluble drug, was encapsulated into using thin film method. Analytical techniques, including dynamic light scattering (DLS), zeta potential measurement, Fourier‐transform infrared spectroscopy (FT‐IR), proton nuclear magnetic resonance ( 1 H‐NMR) energy‐dispersive X‐ray (EDX), confirmed successful synthesis functionalization nanoparticles. The OCION–CPF demonstrated high encapsulation efficiency for QCT pH‐responsive release, as shown loading capacity release kinetics study. exhibited dual‐targeting due properties OCION folate receptor binding ability conferred folic (FA) modification. OA, Chol, PEG, FA IONPs addressed limitations individual targeting strategies, enhancing stability effectiveness delivering approach presents promising advancement in targeted efficient technologies.

Язык: Английский

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Biotransformation and Biological Fate of Magnetic Iron Oxide Nanoparticles for Biomedical Research and Clinical Applications

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding the (bio)transformations that nanoparticles undergo living organisms.

Язык: Английский

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Iron Oxide Nanoparticle-Based T1 Contrast Agents for Magnetic Resonance Imaging: A Review

Nanomaterials, Год журнала: 2024, Номер 15(1), С. 33 - 33

Опубликована: Дек. 28, 2024

This review highlights recent progress in utilizing iron oxide nanoparticles (IONPs) as a safer alternative to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI). It consolidates findings from multiple studies, discussing current T

Язык: Английский

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Influence of protein composition on thermodynamics of biomolecular interactions of iron oxide nanoformulations

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126741 - 126741

Опубликована: Дек. 1, 2024

Язык: Английский

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