A multifaceted microenvironment nanonanoregulator for targeted ovarian cancer therapy DOI Creative Commons
Yizheng Zu, Min Li, R. Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for modulating the tumor microenvironment. However, concerns regarding biosafety animal-derived EXOs pose significant challenges to development innovative formulations. In this study, we propose universal engineer plant-derived as microenvironment nanoregulators targeted therapy. derived from ginger were purified, loaded with natural bioactive compound curcumin (Cur) high encapsulation efficiency, functionalized tumor-targeting aptamer. Upon intravenous administration, resulting multifaceted nanoregulator, termed AGE@Cur, effectively accumulates at site exerts tumor-suppressive effect through remodeling This novel platform not only addresses limitations but also paves way regulators in clinical applications.

Язык: Английский

A multifaceted microenvironment nanonanoregulator for targeted ovarian cancer therapy DOI Creative Commons
Yizheng Zu, Min Li, R. Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for modulating the tumor microenvironment. However, concerns regarding biosafety animal-derived EXOs pose significant challenges to development innovative formulations. In this study, we propose universal engineer plant-derived as microenvironment nanoregulators targeted therapy. derived from ginger were purified, loaded with natural bioactive compound curcumin (Cur) high encapsulation efficiency, functionalized tumor-targeting aptamer. Upon intravenous administration, resulting multifaceted nanoregulator, termed AGE@Cur, effectively accumulates at site exerts tumor-suppressive effect through remodeling This novel platform not only addresses limitations but also paves way regulators in clinical applications.

Язык: Английский

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