Nanoparticle-Enhanced Collagen Hydrogels for Chronic Wound Management

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(3), С. 91 - 91

Опубликована: Март 5, 2025

Chronic wound infections present a persistent medical challenge; however, advancements in dressings and antimicrobial nanomaterials offer promising solutions for improving healing outcomes. This study introduces hydrothermal synthesis approach producing zinc oxide (ZnO) copper (CuO) nanoparticles, subsequently incorporated into PLGA microspheres embedded within collagen hydrogels. The nanoparticles’ physicochemical properties were characterized using X-ray diffraction (XRD) to confirm crystalline structure, scanning electron microscopy (SEM) surface morphology, Fourier-transform infrared spectroscopy (FT-IR) verify functional groups successful hydrogel integration. hydrogels tested activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, which are key pathogens chronic wounds. Biocompatibility was assessed the human HaCat keratinocyte cell line. Both ZnO- CuO-loaded exhibited broad-spectrum efficacy. Cytocompatibility tests demonstrated that both sustain viability proliferation, highlighting their biocompatibility suitability applications, with superior biological performance of ZnO-loaded Furthermore, distinct profiles ZnO CuO suggest tailored use based on microbial composition, excelling antibacterial applications showing potential antifungal treatments. These results underscore nanoparticle-based as innovative therapeutic tools managing

Язык: Английский

Cassia Sericea Leaf Extract for Eco-Friendly Synthesis of Silver and Gold Nanoparticles with Boosted Wound Healing and Antimicrobial Potential

Arabian Journal for Science and Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский