Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications
Gels,
Год журнала:
2025,
Номер
11(4), С. 271 - 271
Опубликована: Апрель 5, 2025
Collagen-based
wound
dressings
have
developed
as
an
essential
component
of
contemporary
care,
utilizing
collagen’s
inherent
properties
to
promote
healing.
This
review
thoroughly
analyzes
collagen
dressing
advances,
examining
different
formulations
such
hydrogels,
films,
and
foams
that
enhance
care.
The
important
processes
by
which
promotes
healing
(e.g.,
promoting
angiogenesis,
encouraging
cell
proliferation,
offering
structural
support)
are
discussed
clarify
its
function
in
tissue
regeneration.
effectiveness
adaptability
demonstrated
via
clinical
applications
investigated
acute
chronic
wounds.
Additionally,
commercially
accessible
collagen-based
skin
treatments
discussed,
demonstrating
their
practical
use
healthcare
settings.
Despite
the
progress,
study
discusses
obstacles
restrictions
encountered
producing
adopting
dressings,
difficulties
manufacturing
financial
concerns.
Finally,
current
landscape’s
insights
indicate
future
research
possibilities
for
optimization,
bioactive
agent
integration,
overcoming
existing
constraints.
analysis
highlights
potential
innovations
improve
treatment
methods
patient
Язык: Английский
Bioadhesive Nanoparticles in Topical Drug Delivery: Advances, Applications, and Potential for Skin Disorder Treatments
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 229 - 229
Опубликована: Фев. 10, 2025
Skin
disorders
are
the
fourth
most
common
cause
of
all
diseases,
which
affect
nearly
one-third
world’s
population.
Topical
drug
delivery
can
be
effective
in
treating
a
range
skin
disorders,
including
microbial
infections,
cancer,
dermatitis,
burn
injury,
wounds,
and
psoriasis.
Bioadhesive
nanoparticles
(BNPs)
serve
as
an
efficient
topical
system
they
dual
purposes
bioadhesives
nanocarriers,
mediate
targeted
delivery,
prolong
retention
time,
deepen
penetration
through
layers.
There
is
increasing
demand
for
BNP-based
applications
medicine
because
their
various
advantages,
biodegradability,
flexibility,
biocompatibility,
enhanced
adhesive
strength.
A
number
BNPs
have
already
been
developed
evaluated
potential
systems.
In
addition,
studies
carried
out
to
evaluate
treatment
atopic
irritant
contact
psoriasis,
severe
injuries.
This
review
article
timely
unique,
it
provides
extensive
unique
summary
recent
advances
wide-ranging
disorders.
Moreover,
this
also
useful
discussion
on
bioadhesion
mechanism
biopolymers
that
used
prepare
BNPs.
Язык: Английский
Toxicity assessment of collagen from Decapterus macarellus: a zebrafish model study
Beni-Suef University Journal of Basic and Applied Sciences,
Год журнала:
2025,
Номер
14(1)
Опубликована: Фев. 27, 2025
Abstract
Background
Collagen,
derived
from
various
biological
sources,
is
crucial
in
supporting
a
range
of
physiological
processes
and
developmental
pathways.
However,
concerns
have
been
raised
regarding
the
potential
teratogenic
effects
collagen.
The
zebrafish
(
Danio
rerio
)
model
has
emerged
as
premier
vertebrate
for
investigating
impact
biomaterials
on
development,
both
under
normal
pathological
conditions.
present
study
sought
to
assess
acute
toxicity,
cardiotoxicity,
toxicity
fish
collagen
extracted
Decapterus
macarellus
species
parameters.
Acid-solubilized
was
D.
,
embryos
(<
96
h)
were
subsequently
exposed
varying
concentrations
62.5
parts
per
million
(ppm),
125
ppm,
250
500
1000
ppm.
Key
parameters,
including
survival
rate,
hatching
heart
deviations
four
apical
points:
embryo
coagulation,
lack
somite
formation,
non-detachment
tail,
heartbeat
observations
recorded
over
period
0–96
h
post-fertilization
(hpf).
Positive
negative
controls
parallelly
carried
out
analysing
results
statistically
with
pairwise
Kruskal–Wallis
test
followed
by
Dunn
test.
Results
indicated
that
rate
ranged
96.97
±
5.25
82.28
9.80%
at
hpf
across
all
tested
concentrations.
No
significant
differences
observed
P
>
0.05)
compared
control
group
or
between
treated
48
rates
72
groups
showed
no
variations
0.05).
Furthermore,
abnormal
changes
points;
embryos,
All
cumulatively
nontoxic
effect
development.
Conclusions
confirm
causes
It
further
validates
using
biocompatible
material,
where
non-toxicity
safety
are
paramount.
Язык: Английский
Flavonoid-Based Nanogels: A Comprehensive Overview
Gels,
Год журнала:
2025,
Номер
11(4), С. 267 - 267
Опубликована: Апрель 4, 2025
The
growing
field
of
nanotechnology
has
recently
given
much
attention
to
nanogels,
which
are
versatile
formulas
and
have
promising
biomedical
applications.
Nanogels
or
nanohydrogels
undergone
significant
development
in
various
fields
industrial
research
meet
increasing
demands,
such
as
pharmaceuticals,
cosmetics,
food,
genetic
engineering.
that
contain
flavonoids,
secondary
metabolites
found
plants,
starting
become
distinctive
reveal
their
unique
characteristics.
objective
the
article
is
provide
a
comprehensive
overview
recent
articles
on
flavonoid-based
emphasizing
general
aspects
regarding
nanogel
formulation
structural
characterization,
well
advancements
made
field.
In
conclusion,
this
outlines
up-to-date
developments
synthesis,
formulation,
therapeutic
applications
important
role
nanotechnology.
Язык: Английский