Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 281 - 281
Опубликована: Фев. 20, 2025
The
blood–brain
barrier
(BBB)
is
a
critical
structure
that
maintains
brain
homeostasis
by
selectively
regulating
nutrient
influx
and
waste
efflux.
Not
surprisingly,
it
often
compromised
in
neurodegenerative
diseases.
In
addition
to
its
involvement
these
pathologies,
the
BBB
also
represents
significant
challenge
for
drug
delivery
into
central
nervous
system.
Nanoparticles
(NPs)
have
been
widely
explored
as
carriers
capable
of
overcoming
this
effectively
transporting
therapies
brain.
However,
their
potential
directly
address
ameliorate
dysfunction
has
received
limited
attention.
review,
we
examine
how
NPs
enhance
across
treat
diseases
explore
emerging
strategies
restore
integrity
vital
structure.
Язык: Английский
Neuroinflammation and energy metabolism: a dual perspective on ischemic stroke
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 10, 2025
Ischemic
stroke
is
a
prevalent
form
of
cerebrovascular
accident,
with
its
pathogenesis
involving
the
intricate
interplay
between
neuroinflammation
and
energy
metabolism.
Cerebral
ischemia
disrupts
oxygen
supply,
triggering
metabolic
dysregulation
activating
neuroinflammatory
responses,
ultimately
resulting
in
cellular
damage.
This
review
provides
an
exhaustive
analysis
complex
mechanisms
ischemic
stroke,
particular
focus
on
interaction
The
interruption
supply
due
to
cerebral
initiates
activates
including
release
inflammatory
cytokines
activation
immune
cells,
contributing
damage
further
disturbances.
Studies
indicate
that
metabolism
significantly
impairs
neural
cell
function
interacts
neuroinflammation,
exacerbating
brain
injury.
Therapeutic
strategies
primarily
concentrate
modulating
suppressing
emphasizing
importance
in-depth
research
into
their
provide
theoretical
foundation
for
new
treatment
stroke.
Future
should
how
balance
anti-inflammatory
regulation
minimize
promote
recovery.
Язык: Английский
Utilizing Nanomaterials in Microfluidic Devices for Disease Detection and Treatment
Nanomaterials,
Год журнала:
2025,
Номер
15(6), С. 434 - 434
Опубликована: Март 12, 2025
Microfluidic
technology
has
gained
widespread
application
in
the
field
of
biomedical
research
due
to
its
exceptional
sensitivity
and
high
specificity.
Particularly
when
combined
with
nanomaterials,
synergy
between
two
significantly
advanced
fields
such
as
precision
medicine,
drug
delivery,
disease
detection,
treatment.
This
article
aims
provide
an
overview
latest
achievements
microfluidic
nanomaterials
detection
It
delves
into
applications
detecting
blood
parameters,
cardiovascular
markers,
neurological
tumor
markers.
Special
emphasis
is
placed
on
their
roles
treatment,
including
models
vessels,
blood–brain
barrier,
lung
chips,
tumors.
The
development
emerging
medical
technologies,
particularly
skin
interactive
devices
imaging,
also
introduced.
Additionally,
challenges
future
prospects
current
clinical
are
discussed.
In
summary,
play
indispensable
role
With
continuous
advancement
technology,
will
become
even
more
profound
extensive.
Язык: Английский
Protein-based nano delivery systems focusing on protein materials, fabrication strategies and applications in ischemic stroke intervention: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
311, С. 143645 - 143645
Опубликована: Апрель 29, 2025
Язык: Английский
Construction of fibromodulin and borneol-clacked phosphorus dendrimer nanoparticles to reduce inflammation and oxidative stress in BBB to nursing care and ischemic stroke therapy
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 24, 2025
Язык: Английский
Revolutionizing Neurological Therapies: The Multifaceted Potential of Zein-Based Nanoparticles for Brain-Targeted Drug Delivery
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 25, 2025
Zein
nanoparticles
(ZNPs)
have
gained
significant
attention
as
biocompatible
and
biodegradable
nanocarrier
systems
for
brain-targeted
drug
delivery.
Their
ability
to
encapsulate
hydrophobic
drugs
undergo
surface
modifications
enables
effective
blood-brain
barrier
(BBB)
penetration
through
receptor-mediated
transcytosis.
Functionalization
approaches,
such
PEGylation
ligand
conjugation,
been
explored
enhance
BBB
transport
improve
bioavailability.
Additionally,
ZNPs
hold
the
potential
theranostic
applications,
integrating
delivery
with
real-time
diagnostics
facilitate
personalized
treatment
strategies.
This
review
provides
a
comprehensive
evaluation
of
ZNPs,
discussing
their
fabrication
techniques,
modifications,
mechanisms
across
BBB.
A
comparative
analysis
other
(liposomes,
polymeric
NPs,
dendrimers,
lipid-based
carbon
nanotubes)
highlights
superior
biodegradability,
lower
toxicity,
clinical
translation.
Furthermore,
we
explore
latest
advancements
in
ZNP-based
neurological
disorders,
including
glioblastoma,
Parkinson's,
Alzheimer's.
Despite
advantages,
translation
remains
challenging
due
scalability
issues,
batch-to-batch
variability,
regulatory
constraints.
Future
research
should
optimize
functionalization
strategies,
release
kinetics,
conduct
long-term
safety
evaluations.
With
continued
nanotechnology
pharmaceutical
engineering,
represent
promising,
sustainable
platform
improving
therapeutic
interventions.
Язык: Английский