Sphingosine-1-Phosphate Metabolic Pathway in Cancer: Implications for Therapeutic Targets
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1056 - 1056
Опубликована: Янв. 26, 2025
Cancer
biology
revolves
around
understanding
how
cells
undergo
uncontrolled
proliferation
leading
to
the
formation
of
malignant
tumors.
Key
aspects
include
self-sufficiency
in
growth
signals,
lack
response
signals
inhibition,
evasion
apoptosis,
sustained
angiogenesis,
immune
response,
capacity
invade
and
metastasize,
alterations
cellular
metabolism.
A
vast
amount
research,
which
is
exponentially
growing,
over
past
few
decades
highlights
role
sphingolipids
cancer.
They
act
not
only
as
structural
membrane
components
but
also
bioactive
molecules
that
regulate
cell
fate
different
physio-pathological
conditions.
In
cancer,
sphingolipid
metabolism
dysregulated,
contributing
tumor
progression,
metastasis,
drug
resistance.
this
review,
we
outline
impact
sphingosine-1-phosphate
(S1P)
a
key
We
give
an
overview
its
summarizing
S1P
intracellular
extracellular
mediator
through
specific
plasma
receptors
cancers.
describe
previous
findings
on
disruption
balance
between
ceramide
(Cer)
common
cancer
can
contribute
tumorigenesis
resistance
chemotherapy.
finally
consider
potential
targeting
metabolic
pathways
well
transporters
promising
therapeutic
approach
treatments.
Язык: Английский
Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment
Cancer Management and Research,
Год журнала:
2025,
Номер
Volume 17, С. 249 - 266
Опубликована: Фев. 1, 2025
Abstract:
Lung
cancer,
with
its
high
incidence
and
mortality
rates,
has
garnered
significant
attention
in
the
medical
community.
The
tumor
microenvironment
(TME),
composed
of
cells,
stromal
extracellular
matrix,
surrounding
blood
vessels,
other
signaling
molecules,
plays
a
pivotal
role
development
lung
cancer.
Stromal
cells
within
TME
hold
potential
as
therapeutic
targets
for
cancer
treatment.
However,
precise
comprehensive
mechanisms
by
which
contribute
to
progression
have
not
been
fully
elucidated.
This
review
aims
explore
through
promote
development,
particular
focus
on
how
immune
tumor-associated
fibroblasts,
endothelial
suppression,
inflammation,
angiogenesis.
goal
is
provide
new
insights
strategies
diagnosis
treatment
Keywords:
microenvironment,
cancer-associated
Язык: Английский