Poly(oligoethylene glycol methylether methacrylate-co-methyl methacrylate) Aggregates as Nanocarriers for Curcumin and Quercetin

Polymers, Год журнала: 2025, Номер 17(5), С. 635 - 635

Опубликована: Фев. 27, 2025

Amphiphilic statistical copolymers can be utilized for the formulation of nanocarriers drug delivery insoluble substances. Oligoethylene glycol methylether methacrylate and methyl are two biocompatible monomers that used biological applications. In this work, synthesis linear poly(oligoethylene methacrylate-co-methyl methacrylate), P(OEGMA-co-MMA), via reversible addition fragmentation chain transfer (RAFT) polymerization is reported. P(OEGMA-co-MMA) with different comonomer compositions were synthesized characterized by size exclusion chromatography (SEC), 1H-NMR, ATR-FTIR spectroscopy. Self-assembly studies carried out dissolution polymers in water co-solvent protocol. For characterization formed nanoaggregates, DLS, zeta potential, fluorescence spectroscopy (FS) experiments performed. Such measurements delineate association into aggregates structural characteristics dependent on copolymer composition. order to investigate encapsulation properties nanoparticles, curcumin quercetin loaded them. The protocol was followed varying concentrations drugs. Nanocarrier confirmed DLS while UV-Vis FS revealed loading optical drug-loaded nanosystems each case. maximum efficiency found 54% 49% quercetin. all nanocarriers, preliminary qualitive biocompatibility conducted FBS medium aqueous solutions which resulted no significant interactions between serum proteins. Novel fabricated as a first step utilization these nanomedicine.

Язык: Английский

Engineering Polymers: From Biodegradable Platforms to Intelligent Drug Carriers

Polymer-Plastics Technology and Materials, Год журнала: 2025, Номер unknown, С. 1 - 27

Опубликована: Апрель 4, 2025

Язык: Английский