Dual‐Carriers of Tartary Buckwheat‐Derived Exosome‐Like Nanovesicles Synergistically Regulate Glucose Metabolism in the Intestine‐Liver Axis DOI Open Access
Dan Li,

Gaoyang Yi,

Guifang Cao

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Abstract The utilization of plant‐derived exosome‐like nanovesicles (ELNs) as nanocarriers for oral delivery bioactives has garnered significant attention. However, their distinctive lipid membrane composition may result in elevated permeability within the gastrointestinal environment, leading to leakage carried bioactives. Inspired by concept projectile design, Tartary buckwheat‐derived ELNs (TB‐ELNs) based dual‐carriers are fabricated loading chlorogenic acid (CGA) into cores and bonding selenium nanoparticles (SeNPs) membrane. results indicate that SeNPs bond markedly augments rigidity, therefore enhances stability TB‐ELNs retention rate loaded CGA during digestion. In vitro vivo studies indicates internalized epithelial cells transcytosis via endoplasmic reticulum, show synergistic regulatory effect on high‐fat diet‐induced hyperglycemia intestine‐liver axis. These be attributed fact combination reduces degradation Moreover, with antioxidant property can protect from oxidative damage, thereby enhancing biological activities. Collectively, this study offers a new strategy develop highly efficient systems alleviate diabetes.

Язык: Английский

Dual‐Carriers of Tartary Buckwheat‐Derived Exosome‐Like Nanovesicles Synergistically Regulate Glucose Metabolism in the Intestine‐Liver Axis DOI Open Access
Dan Li,

Gaoyang Yi,

Guifang Cao

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Abstract The utilization of plant‐derived exosome‐like nanovesicles (ELNs) as nanocarriers for oral delivery bioactives has garnered significant attention. However, their distinctive lipid membrane composition may result in elevated permeability within the gastrointestinal environment, leading to leakage carried bioactives. Inspired by concept projectile design, Tartary buckwheat‐derived ELNs (TB‐ELNs) based dual‐carriers are fabricated loading chlorogenic acid (CGA) into cores and bonding selenium nanoparticles (SeNPs) membrane. results indicate that SeNPs bond markedly augments rigidity, therefore enhances stability TB‐ELNs retention rate loaded CGA during digestion. In vitro vivo studies indicates internalized epithelial cells transcytosis via endoplasmic reticulum, show synergistic regulatory effect on high‐fat diet‐induced hyperglycemia intestine‐liver axis. These be attributed fact combination reduces degradation Moreover, with antioxidant property can protect from oxidative damage, thereby enhancing biological activities. Collectively, this study offers a new strategy develop highly efficient systems alleviate diabetes.

Язык: Английский

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