Advances of Metal‐Based Nanomaterials in the Prevention and Treatment of Oral Infections

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

The complicated environment of the oral cavity presents significant challenges to traditional antibacterial approaches, which has driven exploration novel therapeutic strategies. Metal-based nanomaterials (MNMs), with diverse mechanisms (e.g., membrane disruption, oxidative stress) and evolution from empirical theory-guided design, exhibit immense potential. This review introduces pioneering Hierarchical Response Strategy Framework, systematically classifying MNM systems into three progressive levels: Primary category, comprising MNMs that exert spontaneous effects based on inherent physicochemical properties ion release); Secondary including precisely controlled actions by microenvironmental or stimulus-responsive light-induced ROS); Tertiary encompassing integrate regenerative functions for multidimensional therapy remineralization). Through this framework, authors elucidate MNMs' transition single-function precision-controlled, multifunctional synergy, analyze impact metal elements structural design efficacy, summarize their applications in dental caries, endodontic infections, periodontal disease, etc. framework offers a perspective existing research theoretical foundation rational next-generation precise, smart, comprehensive anti-infective materials.

Язык: Английский

Metal-Polyphenol Nanocomposite Hybrid Hydrogel: A Multifunctional Platform for Treating Diabetic Foot Ulcers through Metabolic Microenvironment Reprogramming

Biomaterials, Год журнала: 2025, Номер 322, С. 123414 - 123414

Опубликована: Май 17, 2025

Язык: Английский