Saudi Journal of Biological Sciences,
Год журнала:
2023,
Номер
30(7), С. 103687 - 103687
Опубликована: Май 19, 2023
Polycystic
ovary
syndrome
(PCOS)
is
an
ovarian
health
condition
as
well
a
long-term
endocrine
dysfunction
that
affects
reproductive-aged
women.
Toll-like
receptor
2
(TLR2)
gene
was
linked
to
PCOS
and
chronic
inflammation,
the
prevalence
of
obesity
rising
in
Saudi
Previous
studies
on
rs5743708
polymorphism
were
documented
In
this
study,
we
investigated
molecular
role
TLR2
among
women
diagnosed
with
using
Rotterdam
criteria.
Blood
samples
collected
from
220
hospital-based
case-control
study;
110
remaining
non-PCOS
(control
women).
Biochemical
analysis
performed
serum
samples,
EDTA
blood.
Genotyping
for
polymerase
chain
reaction-restriction
fragment
length
analysis.
both
groups,
clinical
data
calculated
t-test,
which
revealed
positive
(p
<
0.05)
negative
>
associations.
HWE
supported
0.05).
polymorphism,
none
genotypes,
genetic
models,
or
allele
frequencies
found
be
associated
However,
ANOVA
regression
analyses
relationship
weight
BMI
0.0001).
The
not
One
predictions
could
42.7%
73.6%
obese,
has
been
previous
studies.
This
study
suggests
screening
additional
polymorphisms
large
sample
size.
Gynecological Endocrinology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Май 6, 2025
Sex
hormone-binding
globulin
(SHBG)
is
suggested
to
be
a
biomarker
for
metabolic
disturbances
in
women
with
polycystic
ovary
syndrome
(PCOS).
Insulin
resistance
and
hyperinsulinemia
common
PCOS
patients.
Low
SHBG
increases
free
testosterone
levels,
which
further
induces
hyperinsulinemia.
There
no
established
cutoff
level
The
goal
of
this
study
examine
as
dysregulation
European
relation
hyperandrogenemia.
Retrospective
data
was
collected
from
the
outpatient
clinic
menstrual
cycle
disorders
at
Maastricht
University
Medical
Center+.
208
were
included,
aged
between
18
40
years
old.
During
one-time
visit
clinic,
physical
examination
vaginal
ultrasound
evaluation
performed
well
endocrine
after
overnight
fast.
diagnosed
according
Society
Human
Reproduction
Embryology
(ESHRE)
2018
guideline.
BMI
inversely
associated
(β
-0.598,
95%
CI
[-0.710
-0.485])
waist
circumference
-0.604,
[-0.715
-0.492]),
even
correction
HOMA-IR
testosterone.
A
<40
nmol/L
significantly,
unfavorably,
all
outcomes.
Its
AUROC
optimal
(sensitivity
0.75,
specificity
0.82).
levels
are
indicative
PCOS.
Waist
an
important
predictor
SHBG,
comparable
BMI.
Visceral
adiposity
might
play
role
expression
etiology
Saudi Journal of Biological Sciences,
Год журнала:
2023,
Номер
30(7), С. 103687 - 103687
Опубликована: Май 19, 2023
Polycystic
ovary
syndrome
(PCOS)
is
an
ovarian
health
condition
as
well
a
long-term
endocrine
dysfunction
that
affects
reproductive-aged
women.
Toll-like
receptor
2
(TLR2)
gene
was
linked
to
PCOS
and
chronic
inflammation,
the
prevalence
of
obesity
rising
in
Saudi
Previous
studies
on
rs5743708
polymorphism
were
documented
In
this
study,
we
investigated
molecular
role
TLR2
among
women
diagnosed
with
using
Rotterdam
criteria.
Blood
samples
collected
from
220
hospital-based
case-control
study;
110
remaining
non-PCOS
(control
women).
Biochemical
analysis
performed
serum
samples,
EDTA
blood.
Genotyping
for
polymerase
chain
reaction-restriction
fragment
length
analysis.
both
groups,
clinical
data
calculated
t-test,
which
revealed
positive
(p
<
0.05)
negative
>
associations.
HWE
supported
0.05).
polymorphism,
none
genotypes,
genetic
models,
or
allele
frequencies
found
be
associated
However,
ANOVA
regression
analyses
relationship
weight
BMI
0.0001).
The
not
One
predictions
could
42.7%
73.6%
obese,
has
been
previous
studies.
This
study
suggests
screening
additional
polymorphisms
large
sample
size.
