Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Май 19, 2025
Background Polycystic ovary syndrome (PCOS) is associated with increased risk of gestational diabetes mellitus (GDM), but reliable early predictive biomarkers remain lacking. This study investigated the value serum Sortilin, HMGB1, and galanin-like peptide (GALP) for GDM development in PCOS pregnancies. Methods prospective cohort enrolled 139 patients. Serum HMGB1 GALP levels were measured by ELISA at 8-12 weeks. was diagnosed 24-28 weeks using 75g OGTT (IADPSG criteria). Predictive performance assessed multivariable logistic regression receiver operating characteristic (ROC) curve analysis, adjustment maternal age, BMI, lipid profiles. Results The PCOS-GDM group (n=60) showed significantly higher all versus controls (n=79) (all p<0.001). (aOR=1.55, 95%CI:1.05-1.92) (aOR=1.65, 95%CI:1.50-1.79) independently predicted after adjustment. combined model achieved superior prediction (AUC=0.84, 95%CI:0.74-0.94) individual markers. Conclusion are promising predictors pregnancies, assessment offering optimal stratification. These findings may facilitate timely intervention high-risk populations.
Язык: Английский