Transcriptome analysis reveals that the injection of mesenchymal stem cells remodels extracellular matrix and complement components of the brain through PI3K/AKT/FOXO1 signaling pathway in a neuroinflammation mouse model

Genomics, Год журнала: 2025, Номер 117(3), С. 111033 - 111033

Опубликована: Март 22, 2025

Язык: Английский

---

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Март 27, 2025

Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.

Язык: Английский

---

IL-17 A Exacerbated Neuroinflammatory and Neurodegenerative Biomarkers in Intranasal Amyloid-Beta Model of Alzheimer’s Disease

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Март 31, 2025

Язык: Английский

---

Alzheimer's disease and the immune system: A comprehensive overview with a focus on B cells, humoral immunity, and immunotherapy

Journal of Alzheimer s Disease Reports, Год журнала: 2025, Номер 9

Опубликована: Янв. 1, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the major cause of dementia. Amyloid-β (Aβ) tau aggregation, mitochondrial dysfunction, microglial dysregulation are key contributors to AD pathogenesis. Impairments in blood-brain barrier have unveiled contribution immune system, particularly B cells, pathology. crucial component adaptive immunity, exhibit diverse functions, including antigen presentation antibody production. While their role neuroinflammatory disorders has been well-documented, specific function lacks adequate data. This review examines dual cells humoral immunity modulating brain inflammation explores recent advancements passive active immunotherapeutic strategies targeting pathobiology. We summarize preclinical clinical studies investigating cell frequency, altered levels, implications neuroinflammation immunotherapy. Notably, demonstrate protective pathological roles AD, influencing neurodegeneration through antibody-mediated clearance toxic aggregates inflammatory activation inflammation. Passive immunotherapies Aβ shown potential reducing amyloid plaques, while emerging as promising strategies, requiring further validation. Understanding interplay between microglia, dysfunction critical unraveling Their nature progression underscores need for precise therapeutic interventions optimize immunotherapy outcomes mitigate effectively.

Язык: Английский

---

The Role of Semaphorin 3 A in the Pathogenesis and Progression of Alzheimer’s Disease and Other Aging-Related Diseases: A Comprehensive Review

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107732 - 107732

Опубликована: Апрель 1, 2025

Язык: Английский

---