Clinical significance of RNA methylation in hepatocellular carcinoma

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 2, 2024

Abstract Hepatocellular carcinoma (HCC) is a primary liver malignancy with high mortality rates and poor prognosis. Recent advances in high-throughput sequencing bioinformatic technologies have greatly enhanced the understanding of genetic epigenetic changes cancer. Among these changes, RNA methylation, most prevalent internal modification, has emerged as significant contributor development progression HCC. Growing evidence reported significantly abnormal levels methylation dysregulation RNA-methylation-related enzymes HCC tissues cell lines. These alterations play crucial role regulation various genes signaling pathways involved HCC, thereby promoting tumor progression. Understanding pathogenesis would help developing prognostic biomarkers targeted therapies for Targeting molecules shown promising potential management terms novel Exploring clinical application may provide new insights approaches Further research this field warranted to fully understand functional roles underlying mechanisms In review, we described multifaceted Moreover, prospects are discussed, which basis subsequent in-depth on

Язык: Английский

mRNA m6A detection

Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)

Опубликована: Дек. 12, 2024

Язык: Английский

Recent insights into RNA m5C methylation modification in hepatocellular carcinoma

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер unknown, С. 189223 - 189223

Опубликована: Ноя. 1, 2024

Язык: Английский